Journals / Uzmanlık Sonrası Eğitim ve Güncel Gelişmeler Dergisi / 2006 / Cilt: 3 - Sayı: 4

Hyperemesis gravidarum and Helicobacter pylori: Review

Hiperemezis gravidarum ve Helicobacter pylori: Derleme

Pages
235–241
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Finally, with this study we reviewed all the published evidence for the causal role of H.pylori in hyperemesis gravidarum.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:70-85% of pregnant women complain of nausea and vomiting.
📊
Key Findings & Data:More severe presentation of these symptoms accompanied by weight loss, malnutrition and fluid electrolyte imbalance forms the clinical picture, classically named Hyperemesis gravidarum.
💡
Conclusion & Impact:Finally, with this study we reviewed all the published evidence for the causal role of H.pylori in hyperemesis gravidarum.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Hiperemezis gravidarum · Helicobacter pylori · Hyperemesis Gravidarum

Abstract

70-85% of pregnant women complain of nausea and vomiting. More severe presentation of these symptoms accompanied by weight loss, malnutrition and fluid electrolyte imbalance forms the clinical picture, classically named Hyperemesis gravidarum. The pathophysiology of this clinical picture has been hypothesized to be connected with endocrinological factors (human chorionic gonadotropin, progesterone, estrogen, thyroid hormones), immunological, metabolic, anatomical, psychological factors and more recently with an infectious agent, Helicobacter Pylori (H.pylori). H. Pylori is a spiral shaped, whip-like tailed gram negative bacteria, which is capable of surviving in the gastric antrum. Degradation of urea with the urease enzyme produced by this microorganism raises the local pH which makes the conditions more favorable for survival. H.pylori has already been shown to be etiologically related to chronic antral gastritis, peptic ulcer and gastric cancer. Finally, with this study we reviewed all the published evidence for the causal role of H.pylori in hyperemesis gravidarum.

Özet

Bulantı ve kusma gebe kadınların %70-85’inde görülen bir durumdur. Bu semptomların daha şiddetli olduğu ve ayrıca kilo kaybı, beslenme bozukluğu, sıvı-elektrolit imbalansının eşlik ettiği klinik tabloya Hiperemezis gravidarum (H.gravidarum) denir. Bu klinik tablonun etyopatogenezi için endokrinolojik (Human koryonik gonodotropin-_hCG, progesteron, östrojen, tiroid hormonları), immunolojik, metabolik, anatomik, psikolojik faktörlerin yanısıra son yıllarda yapılan çalışmalarda Helicobacter pylori (H.pylori) enfeksiyonunun da rol oynayabileceği ileri sürülmüştür. H.pylori; spiral şekilli, kamçılı, mide antrumunda yaşayan gram negatif bir bakteridir. Salgıladığı üreaz enzimi sayesinde üreyi parçalayarak ortam pH’sını yükseltip kendine uygun bir ortam sağlar. Kronik antral gastrit, peptik ülser ve mide kanseri gibi hastalıkların etyopatogenezinde H.pylori’nin rol oynadığı kesin olarak gösterilmiştir. Bu yazı ile biz Helicobacter pylori enfeksiyonunun hiperemezis gravidarum etyopatogenezindeki yerini literatür araştırması ile gözden geçirdik.

🔖

Cite This Article

KÜÇÜKKÖMÜRCÜ, Ş., ÖZAKIN, C., ÖZDİL, M., ÖZYÜREK, E. Ş. (2006). Hyperemesis gravidarum and Helicobacter pylori: Review. Uzmanlık Sonrası Eğitim ve Güncel Gelişmeler Dergisi, Cilt: 3 - Sayı: 4, 235–241. https://ajindex.com/articles/320604

References (19)

  1. Jewell D, Young G. Interventions for nausea and vomiting in early pregnancy.The Cochrane Library, Issue 4, 2003. Chichester, UK: John Wiley &Sons, Ltd
  2. Gadsby R, Barnie-AdsheadAM, Jagger C.A prospective study of nausea and vomiting during pregnancy. Br J Gen Pract 1993; 43:245-48
  3. Gadsby R, Barnie-AdsheadAM, Jagger C. Pregnancy nausea related to women’s obstetrics and personel histories. Gynecol Obstet Invest 1997;43:108-11
  4. Gazmararian JA, Peterson R, Jamieson DJ, Schild L, Adams MM,DeshpandeAD. Hospitalizations during pregnancy among managed care enrolles. Obstet Gynecol 2002;100:94-100
  5. Verberg MFG, Gillott DJ, Al-Fardan N, Grudzinskas JG. Hyperemesis gravidarum, a literature review.HumanReproduction Update 2005;11(5):527-39
  6. KlebanoffMA,KoslowePA,KaslowR,RhoadsGG.Epidemiology of vomiting in early pregnancy. Obstet Gynecol 1985;66: 612-16
  7. Goodwin TM. Hyperemesis gravidarum. Clin Obstet Gynecol 1998;41:597-605
  8. Spruill SC, Kuller JA. Hyperemesis gravidarum complicated byWernicke’s encephalopathy. Obstet Gynecol 2002;99:875-78
  9. Gorbach JJ, Counselman FL, Mendelson MH. Spontaneous pneumomediastinum secondary to hyperemesis gravidarum. J Emerg Med 1997;15:639-43
  10. Hill JB,Yost NB,Wendel GD.Acute renal failure in association with severe hyperemesis gravidarum. Obstet Gynecol 2002; 100:1119-121
  11. Gross S, Librach C, CecuttiA. Maternal weight loss associated with hyperemesis gravidarum: a predictor of fetal outcome. Am J Obstet Gynecol 1989;160:906-09
  12. Tsang LS, Katz VL, Wells SD. Maternal and fetal outcomes in hyperemesis gravidarum. Int J Obstet Gynecol 1996;55:231-35
  13. Bailit JL. Hyperemesis gravidarum: Epidemiologic findings from a large cohort. Am J Obstet Gynecol 2005;193:811-14
  14. Quinlan JD, Hill DA. Nausea and vomiting of pregnancy. American Family Physician 2003;68:121-28
  15. Koch KI, Kenneth L, Christine L. Nausea and vomiting during pregnancy. Gastroenterol Clin N Am 2003;32:201-04
  16. Warren JR, Marshall BJ. Unidentified curved bacili on gastric epitelium in active chronic gastritis. Letter to editor. Lancet 1983;1:1273-75
  17. Brooks GF, Janet SB, StephenAM, JawetzM.Melinck&Adelberg’s MedicalMicrobiology, 21.Edition,Appleton&Lange,Connecticut, 1995:242-43
  18. Breuer T, Graham DY. Cost of diagnosis and treatment of Helicobacter pylori infection:When does choosing the treatment regimen based on susceptibility testing become cost effective? Am J Gastroenterol 1999;94:725-29
  19. Sandıkçı MÜ, Köksal F: He