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Journals / Uzmanlık Sonrası Eğitim ve Güncel Gelişmeler Dergisi / 2007 / Cilt: 4 - Sayı: 2

Fas expression in endometriomas, endometrioid carcinomas and clear cell carcinomas of ovaries

Endometriomalar ile overin endometrioid ve berrak hücreli karsinomlarında fas ekspresyonu

Murat ULUKUŞ
Teksin ÇIRPAN
Coşan TEREK
Murat GÖK
Çağnur ULUKUŞ
Osman ZEKİOĞLU
Yılmaz DİKMEN
Ömer DİNÇER
Pages
108–113
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, we suggest that in endometriosis related ovarian tumors apoptotic mechanisms might be more impaired than endometriomas and also decreased expression of Fas might be involved in the malign transformation of endometriosis.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study we aimed to investigate the expression of Fas protein by immunohistochemistry between ovarian endometriomas and endometriosis related ovarian tumors, endometrioid and clear cell carsinomas.
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Key Findings & Data:Ovarian endometriosis (n = 22), ovarian endometrioid adenocarsinomas (n = 12) and ovarian clear cell carsinomas (n =8) histopathologic samples were included in this study.
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Conclusion & Impact:In conclusion, we suggest that in endometriosis related ovarian tumors apoptotic mechanisms might be more impaired than endometriomas and also decreased expression of Fas might be involved in the malign transformation of endometriosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Yumurtalık neoplazmları · İmmünohistokimya · Apoptoz

Abstract

In this study we aimed to investigate the expression of Fas protein by immunohistochemistry between ovarian endometriomas and endometriosis related ovarian tumors, endometrioid and clear cell carsinomas. Ovarian endometriosis (n = 22), ovarian endometrioid adenocarsinomas (n = 12) and ovarian clear cell carsinomas (n =8) histopathologic samples were included in this study. When we compared the epithelial Fas expression among three groups, we observed that endometriomas express significantly higher epithelial Fas than both ovarian tumors (P< 0.001). In conclusion, we suggest that in endometriosis related ovarian tumors apoptotic mechanisms might be more impaired than endometriomas and also decreased expression of Fas might be involved in the malign transformation of endometriosis.

Özet

Bu çalışmada ovaryan endometriomalar ve endometriozisle ilişkili oldukları bilinen overin endometrioid ve berrak hücreli karsinomlarının Fas protein ekspresyonu yönünden immünohistokimyasal yöntemle karşılaştırılmasını amaçladık. Çalışmaya ovaryan endometriyozis (n = 22), overin endometrioid adenokarsinomu (n = 12) ve overin berrak hücreli karsinomu (n = 8) tanısı alan toplam 42 olgu dahil edilmiştir. Her üç grubu epitelyal Fas ekspresyonu açısından kıyasladığımızda endometriyomalı olguların her iki tipteki over karsinomlu olgulara göre istatistiksel olarak daha fazla Fas proteini eksprese ettiklerini gösterdik (P < 0.001). Sonuç olarak endometriomalara kıyasla endometriozisle ilişkili over tümörlerinde apoptozis mekanizmalarının daha da bozulmuş olabileceği ve endometriozisin malign transformasyonuna azalmış Fas proteininin de katkıda bulunabileceği ileri sürülebilir.

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Cite This Article

ULUKUŞ, M., ÇIRPAN, T., TEREK, C., GÖK, M., ULUKUŞ, Ç., ZEKİOĞLU, O., DİKMEN, Y., DİNÇER, Ö. (2007). Fas expression in endometriomas, endometrioid carcinomas and clear cell carcinomas of ovaries. Uzmanlık Sonrası Eğitim ve Güncel Gelişmeler Dergisi, Cilt: 4 - Sayı: 2, 108–113. https://ajindex.com/articles/320553

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