AI Summary & Key Takeaways
AI InsightThese results suggest that CE may cause oxidative stress in rat brain tissues, this oxidative stress may involve in CE toxicity, and melatonin and the combination of vitamin C and vitamin E may decrease these toxic effects caused by CE.
📌 3 Key Takeaways
Abstract
The protective effect of melatonin and the combination of vitamin C and vitamin E on the brain tissue of rats treated with chlorpyriphos-ethyl (CE) was investigated. The experimental groups were as follows: Control group (C), CE treated group (CE), vitamin E plus vitamin C treated group (Vit), melatonin treated group (Mel), vitamin E plus vitamin C plus CE treated group (Vit+CE), and melatonin plus CE treated group (Mel+CE). Vitamins and melatonin were administered to appropriate groups six days. CE was applied only fifth and sixth days. In CE group, comparing with C group, thiobarbituric acid reactive substances was found to increase, whereas antioxidant potential was decreased (p<0,10) in brain tissue homogenates. Superoxide dismutase and glutathione peroxidase activities were high in CE group, comparing with C group (p<0,10). These results suggest that CE may cause oxidative stress in rat brain tissues, this oxidative stress may involve in CE toxicity, and melatonin and the combination of vitamin C and vitamin E may decrease these toxic effects caused by CE.
Özet
Chlorpyriphos-ethyl'e (CE) maruz kalan ratlarin beyin dokularinda melatonin ile vitamin C ve vitamin E kombinasyonunun koruyucu etkileri arastirildi. Deney gruplari su sekilde organize edildi: Kontrol grubu (C), CE verilen grup (CE), vitamin E + vitamin C verilen grup (Vit), melatonin verilen grup (Mel), vitamin E + vitamin C + CE verilen grup (Vit+CE) ve melatonin + CE verilen grup (Mel+CE). Ilgili gruplara alti gün vitaminler ve melatonin verilirken besinci ve altinci gün CE verildi. Beyin dokusu homojenatlarinda CE grubunda C grubuna göre tiobarbitürik asit reaktif substans yüksek iken antioksidan potansiyel düsüktü (p<0,10). Süperoksit dismutaz ve glutatyon peroksidaz aktivitelerinde CE grubunda C grubuna göre düsük bulundu (p<0,10). Sonuçta, CE'nin rat beyin dokusunda oksidatif strese neden oldugu, bu oksidatif stresin CE toksisitesinde rol oynayabilecegi ve melatoninin ile vitamin C ve vitamin E kombinasyonunun CE'nin beyin üzerine toksik etkilerini anlamli olarak azaltabilecegi kanaatine varildi.