SavedAdd your journal

Journals / Solunum Hastalıkları / 2006 / Cilt: 17 - Sayı: 1

Plasma fibrinogen and serum C-reactive protien (CRP) levels in acute exacerbations and stable period of chronic obstructive pulmonary disease (COPD)

Kronik Obstrüktif Akciğer Hastalığı (KOAH)'nda akut atak ve stabil dönemde plazma fibrinojen ve serum C-reaktif protein (CRP) düzeyleri

HANDAN İNÖNÜ KÖSEOĞLU
Sema CANBAKAN
Nermin ÇAPAN
Bahadır BERKTAŞ
ARZU ERDİNÇ ERTÜRK
Meral GÜLHAN
Pages
1–7
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result of this study, we concluded that CRP could be used as the earlier determinant of inflammation in COPD acute exacerbations.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The release of inflammatory mediators are prominence in acute exacerbations of chronic obstructive pulmonary disease (COPD).
📊
Key Findings & Data:Fity-six patients, 46 men and 10 women, with mean age 63.5 ±10.18 (mean ± standard deviation) years, who were hospitalised as COPD acute exacerbations, were included in the study.
💡
Conclusion & Impact:As a result of this study, we concluded that CRP could be used as the earlier determinant of inflammation in COPD acute exacerbations.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:C-reaktif protein · Akciğer hastalığı · kronik obstrüktif

Abstract

The release of inflammatory mediators are prominence in acute exacerbations of chronic obstructive pulmonary disease (COPD). The aim of this study was to compare the plasma fibrinogen and serum CRP levels in acute exacerbations and stable period of COPD. Fity-six patients, 46 men and 10 women, with mean age 63.5 ±10.18 (mean ± standard deviation) years, who were hospitalised as COPD acute exacerbations, were included in the study. Plasma fibrinogen and serum CRP levels were measured. And in 39 patients, who were chosen from the same patient population, all the measurements were repeated in the stable period. With the exclusion of other causes of high serum CRP levels, we found CRP levels as 26:54 ± 4.22 mg/L in acute exacerbations and as 6.075 ± 5.61 mg/L in stable period; the difference was found to be statistically significant (p= 0.0001). The fibrinogen level was found as 5.13 ± 2.56 g/L in acute exacerbations and as 4.29 ± 1.66 g/L in stable period, the difference was found to be statistically significant (p= 0.0001). These results support the idea that fibrinogen and serum CRP are the important signs of local inflammation. As a result of this study, we concluded that CRP could be used as the earlier determinant of inflammation in COPD acute exacerbations.

Özet

Kronik obstrüktif akciğer hastalığı (KOAH)'nda özellikle alevlenmelerde inflamatuvar mediatörlerin salınımı artar. Bu çalışmanın amacı KOAH'lı hastalarda akut atak ve stabil dönemde plazma fibrinojen ve serum C-reaktif protein (CRP) düzeylerini karşılaştırmaktır. Çalışmaya KOAH alevlenmesi nedeniyle hastaneye yatırılan yaş ortalaması (ortalama ± standart sapma) 63.5 ± 10.18 yıl olan, 46'sı erkek 10'u kadın toplam 56 hasta dahil edildi. Aynı hasta popülasyonundan seçilen 39 hastada, plazma fibrinojen ve serum CRP düzeyleri stabil dönemde de bakıldı. CRP'nin serum seviyesini yükseltebilecek diğer nedenleri ekarte ederek çalışmaya aldığımız hastalarda akut dönemde CRP düzeyi (ortalama ± standart sapma) 26.54 ± 4.22 mg/L, stabil dönemde ise 6.075 ± 5.61 mg/L olarak saptandı ve aradaki fark istatistiksel olarak anlamlıydı (p= 0.0001). Akut dönemde fibrinojen düzeyi (ortalama ± standart sapma) 5.13 ± 2.56 g/L, stabil dönemde fibrinojen düzeyi 4.29 ± 1.66 g/L olarak tespit edildi, aradaki fark istatistiksel olarak anlamlıydı (p= 0.0001). Bu sonuçlar, fibrinojen ve CRP'nin lokal inflamasyonu gösteren önemli belirteçler olduğu düşüncesini desteklemiştir. Çalışmamızda, CRP'nin KOAH akut atağında, inflamasyonun erken dönem belirleyicisi olarak kullanılabileceği sonucuna varıldı.

🔖

Cite This Article

KÖSEOĞLU, H. İ., CANBAKAN, S., ÇAPAN, N., BERKTAŞ, B., ERTÜRK, A. E., GÜLHAN, M. (2006). Plasma fibrinogen and serum C-reactive protien (CRP) levels in acute exacerbations and stable period of chronic obstructive pulmonary disease (COPD). Solunum Hastalıkları, Cilt: 17 - Sayı: 1, 1–7. https://ajindex.com/articles/318585

References (19)

  1. Pauwels RA. National and interntional guidelines for COPD. The need for evidence. Chest 2000; 117:20-2
  2. Yıldırım N. Fizyopatoloji. Umut S, Erdinç E, eds. Kronik obstrüktif akciğer hastalığı. İstanbul: Toraks Kitapları, 2000;45-6
  3. Global Initiative for Chronic Obstructive Lung Disease (GOLD). NHLBI/WHO Workshop Report. National Institutes of Health 2003:2
  4. Busset AS. Risk factors for COPD. Eur Respir Rev 1996;6:253-8
  5. Murray CJL, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: Global burden of disease study. Lancet 1997;349:1498-504
  6. Chung KF. Cytokines in chronic obstructive pulmonary disease. Eur Respir J 2001;18(Suppl 34):50-9
  7. Gülmezoğlu E, Ergüven S. İmmünoloji. Akut dönem yanıtı, akut dönem proteinleri 1994;146-50
  8. Steel DM, Whithead AS. The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein. Immunology Today 1994;15:81-8
  9. Kushner I, Ganapathi M, Schultz D. The acute phase response is mediated by heterogenous mechanisms. Ann NY Acad Sci 1989;557:19-30
  10. Ballou SP, Kushner I. C-reactive protein response and the acute phase response. Advances in Internal Medicine 1992,37:313-36
  11. Wedzicha AJ, Terence AR, Seemungal Peter K. Acut exacerbations of Chronic Obstructive Pulmonary Disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels. Thromb Haemost 2000;84:210-5
  12. Dahl M, Hansen A, Vestbo J, Lange P. Elevated plasma fibrinogen associated with reduced pulmonary function and increased risk of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001;164:1008-11
  13. Jousilahti P, Vartiainen E, Tuamilehto J, et al. Symptoms of chronic bronchitis and the risk of coronary disease.Lancet 1996;348:567-72
  14. Meier CR, Jick SS, Derby LE, et al. Acute respiratory tract infections and risk of first-time acute myocardial infarction. Lancet 1998;351:1467-71
  15. Pepys MB. C-reactive protein fifty years on. Lancet 1981;21:653-7
  16. Okamura JM, Miyagi JM, Tenada K, Hokoma Y. Potential clinical applications of C-reactive protein. J Clin Lab Anal 1990;4:231-5
  17. Dev D, Walance E, Sankaran R, Cunnife J. Value of C-reactive protein measurements in exacerbations of chronic obstructive pulmonary disease. Respiratory Medicine 1998;92:664-7
  18. Şentürk T. Romatizmal hastalıkların tanı ve takibinde kullanılan yöntemler. İn: Hiçin C, Ünal S, Biberoğlu K, Akalın S, eds. Temel iç hastalıkları 1996;2:1910
  19. Smith RP, L