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Journals / PTT Hastanesi Tıp Dergisi / 2002 / Cilt: 24 - Sayı: 3

Epithelial cell proliferation and apoptosis inhibition in nasal polyp and antrochoanal polyp tissues. An immunohistochemical study

Nazal polip ve antrokoanal polip dokularında epitel hücre proliferasyonu ve apoptozis inhibisyonu: İmmünhistokimyasal çalışma

Ali ÖZDEK
İlhan MERAL
Ünal BAYIZ
Muzaffer ÇAYDERE
Rahmi KILIÇ
Erdal SAMİM
Pages
143–147
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Nasal polyposis and ACP seem to be different clinical entities in terms of epithelial cell proliferation.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This immunohistochemical study was designed to investigate the differences between nasal polyposis (NP) and antrochoanal polyposis (ACP) in terms of epithelial cell proliferation and apoptosis inhibition.
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Key Findings & Data:Twenty patients with NP (5 females, 15 males; mean age 41 years; range 17-67 years) and 20 patients with ACP (10 females, 10 males; mean age 26 years; range 9-67 years) were randomly selected from among the patients who met the inclusion criteria.
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Conclusion & Impact:Conclusion: Nasal polyposis and ACP seem to be different clinical entities in terms of epithelial cell proliferation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Proto-onkojen proteinler c-bcl-2 · Apoptoz · Hücre bölünmesi

Abstract

Objective: This immunohistochemical study was designed to investigate the differences between nasal polyposis (NP) and antrochoanal polyposis (ACP) in terms of epithelial cell proliferation and apoptosis inhibition. Patients and Methods: Charts of the patients who had been treated surgically with diagnoses of NP or ACP during a four-year period were examined. Twenty patients with NP (5 females, 15 males; mean age 41 years; range 17-67 years) and 20 patients with ACP (10 females, 10 males; mean age 26 years; range 9-67 years) were randomly selected from among the patients who met the inclusion criteria. Tissue sections were prepared for immunohistochemical examination from the archived paraffin-embedded surgical specimens to determine PCNA (proliferating cell nuclear antigen) and bcl-2 expressions. Statistical analyses were made using the Mann-Whitney U-test. Results: The mean PCNA index was found to be significantly higher in NP tissues (17.3±8.7) than in ACP (9.3±8.5) tissues (p=0.003). There was no significant difference between the two groups with respect to bcl-2 expression (NP, 4.8±4.3; AKP1 9.6+11.2; p=0.289). Conclusion: Nasal polyposis and ACP seem to be different clinical entities in terms of epithelial cell proliferation.

Özet

İmmünhistokimyasal yöntemle epitel hücre proliferasyonu ve apoptozis İnhibisyonu açısından nazal polip (NP) ve antrokoanal polip (AKP) dokuları arasında farklılık olup olmadığı araştırıldı. Hastalar ve Yöntemler: Kliniğimizde dört yıllık bir dönem içinde NP ve AKP tanıları ile cerrahi tedavi uygulanan hastaların dosya ve bilgisayar kayıtları retrospektif olarak incelendi. Bu hastalardan çalışma ölçütlerine uyan NP'li 20 olgu (5 kadın, 15 erkek; ört. yaş 41; dağılım 17-67) ve AKP1Ii 20 olgu (10 kadın, 10 er-kek; ört. yaş 26; dağılım 9-67) rastgele seçilerek, patoloji arşivindeki parafine gömülü cerrahi örneklerinden yeni kesitler hazırlandı. Hazırlanan kesitlerde, İmmünhistokimyasal yöntemle PCNA (proliferating cell nuclear antigen) ve bcl-2 ekspresyonu varlığı araştırıldı. Sonuçlar Mann-Whitney U-testi ile istatistiksel olarak karşılaştırıldı. Bulgular: Nazal polip dokusundaki (17.3±8.7) PCNA indeksi, AKP dokusuna (9.3±8.5) göre anlamlı ölçüde yüksek bulundu (p=0.003). İki grup arasında bcl-2 ekspresyonu açısından (NP için 4.8±4.3; AKP için 9.6±11.2) anlamlı bir fark bulunamadı (p=0.289). Sonuç: Nazal polip ve AKP'nin epitel hücre proliferasyonu açısından iki farklı hastalık olduğu sonucuna varıldı.

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Cite This Article

ÖZDEK, A., MERAL, İ., BAYIZ, Ü., ÇAYDERE, M., KILIÇ, R., SAMİM, E. (2002). Epithelial cell proliferation and apoptosis inhibition in nasal polyp and antrochoanal polyp tissues. An immunohistochemical study. PTT Hastanesi Tıp Dergisi, Cilt: 24 - Sayı: 3, 143–147. https://ajindex.com/articles/308690

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