Journals / Retina-Vitreus / 2009 / Cilt: 17 - Sayı: 1

Intravitreal bevacizumab ınjection in patients with choroidal neovascularization due to choroid rupture

Koroid yırtığına ikincil gelişen koroid neovaskülarizasyonunda intravitreal bevacizumab uygulaması

Pages
61–64
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our study shows that intravitreal 1.25 mg bevacizumab can be an effective alternative treatment for choroidal neovascularization (CNV) due to choroidal rupture.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: To describe and report the effect of intravitreal bevacizumab as primary treatment for secondary choroidal neovascularization (CNV) after choroidal rupture due to blunt head trauma.
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Key Findings & Data:Both patients received single intravitreal injection of 1.25 mg (0.05 ml) bevacizumab (as treatment of CNV) after informed consent was signed.
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Conclusion & Impact:Our study shows that intravitreal 1.25 mg bevacizumab can be an effective alternative treatment for choroidal neovascularization (CNV) due to choroidal rupture.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Erişkin · Erkek · Yırtık

Abstract

Purpose: To describe and report the effect of intravitreal bevacizumab as primary treatment for secondary choroidal neovascularization (CNV) after choroidal rupture due to blunt head trauma. The study included two eyes of two patients who presented with choroidal neovascularization secondary to choroidal rupture due to blunt head trauma. Both patients received single intravitreal injection of 1.25 mg (0.05 ml) bevacizumab (as treatment of CNV) after informed consent was signed. Both patient also underwent fundus fluorescein angiography (FA), optic coherence tomography (OCT) before the bevacizumab injection and then three months after. Visual acuity was measured before and after treatment by ETDRS chart. Patients were reexamined on the first day, and monthly thereafter. After intravitreal injection of bevacizumab, the visual acuity and anatomic responses were observed. Both patients showed regression of their neovascularization three months after injection of bevacizumab. No eyes lost vision during follow- up and both eyes showed improvement. At 3rd month of treatment, one eye’s vision improved from 20/60 to 20/20, other eye’s visual acuity (VA) improved from 20/50 to 20/30. Central retinal thickness decreased in both eyes. No cataract progression, endophthalmitis or injection-related complications were encountered. Our study shows that intravitreal 1.25 mg bevacizumab can be an effective alternative treatment for choroidal neovascularization (CNV) due to choroidal rupture.

Özet

Amaç: Künt kafa travması sonrası görülen koroid yırtığına ikincil ortaya çıkan koroid neovaskülarizasyonunda (KNV) intravitreal bevacizumab uygulamasının sonuçlarını bildirmek amaçlandı. Çalışmaya kafa travması sonrası koroid rüptürüne ikincil oluşan koroid yırtığı bulunan iki hastanın iki gözü dahil edildi. Hastalara bilgilendirilip gerekli izinler alındıktan sonra her iki hastaya tek doz 1.25 mg (0.05 ml) bevacizumab intravitreal olarak verildi. Hastaların görme keskinliği enjeksiyon öncesi ve sonrası ETDRS eşeliyle ölçüldü. Hastalara uygulama öncesi ve üç ay sonrası florosein anjiografi (FA) ve optik koherens tomografi (OKT) yapıldı, injeksiyon sonrası ilk gün ve sonrasında aylık olarak kontrol edildi. Bevacizumab injeksiyonu sonrası görme keskinliği ve anatomik cevap takip edildi. Bevacizumab uygulamasından üç ay sonra her iki hastanın da neovaskularizasyonda gerileme tespit edildi. Hastaların üç aylık takibi sonucu görme keskinliklerinde azalma görülmezken görme keskinliği birinci olguda 20/60’dan 20/20’ye; ikinci olguda 20/50’dan 20/30’e çıktı. OKT ‘de santral kalınlıkta her iki gözde de azalma tespit edildi. Çalışma süresince katarakt progresyonu, endoftalmi veya enjeksiyonla ilgili herhangi bir yan etki saptanamadı. Koroid yırtığına ikincil gelişen koroid neovaskularizasyonda intravitreal bevacizumab uygulamasının yeni ve alternatif bir tedavi seçeneği olabileceğini düşünmekteyiz.

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Cite This Article

ARTUNAY, Ö., YÜZBAŞIOĞLU, E., ŞENGÜL, E. A., RASİER, R., BAHÇECİOĞLU, H. (2009). Intravitreal bevacizumab ınjection in patients with choroidal neovascularization due to choroid rupture. Retina-Vitreus, Cilt: 17 - Sayı: 1, 61–64. https://ajindex.com/articles/308083

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