Journals / Retina-Vitreus / 2000 / Cilt: 8 - Sayı: 2

Histopathologic evaluation after intravitreal injection of lidocaine in albino rats

İntravitreal lidokain enjeksiyonu sonrası retinanın histopatolojik incelenmesi

Pages
160–168
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The pathologic changes were due to perforation.

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of this study was to evaluate the direct effect of intraocular lidocaine hydrochloride 2% on intraocular tissues. 0.1 ml of 2% lidocaine hydrochloride (HCI) and 0.1 ml balanced-salt solution (control group) were injected intravitreally in per 16 eyes of total 32 albino rats.
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Key Findings & Data:Anterior and posterior segments were examined and pupil reaction were recorded at every 15 minutes for the first two hours.
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Conclusion & Impact:The pathologic changes were due to perforation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Sıçanlar · Retina · Lidokain

Abstract

The aim of this study was to evaluate the direct effect of intraocular lidocaine hydrochloride 2% on intraocular tissues. 0.1 ml of 2% lidocaine hydrochloride (HCI) and 0.1 ml balanced-salt solution (control group) were injected intravitreally in per 16 eyes of total 32 albino rats. Anterior and posterior segments were examined and pupil reaction were recorded at every 15 minutes for the first two hours. Two eyes of each group were enucleated at 4 and 24 hours and 3, 5, 7, 10, 15 and 20 days later after injection and histopathologic examination was performed. Pupillar dilation was observed in all study eyes up to first 4 hours. No toxic effect of intravitreal lidocaine was detected that cause histologic pathology. But vitreoretinal traction was observed in the eyes that cause histologic pathology But vitreoretinal traction was observed in the eyes that had vitreous hemorrhage. No toxic effect of lidocaine was observed. The pathologic changes were due to perforation.

Özet

Bu çalışmada intraoküler % 2 lidokain HCI'in intraoküler dokulara olan etkilerin araştırılması amaçlamıştır. 32 Wistar albino rat 2 eşit gruba ayrılarak 16'sının sağ gözüne pars plana intraviteal 0.1 ml %2 lidokain, diğer 16 ratın sağ gözüne ise 0.1 ml serum fizyolojik enjekte edildi. İntraviteral enjeksiyon sonrası 1, 4, 8 ve 24. saatte biomikroskop ışığı altında direkt ve konsensüel ışık reaksiyonları değerlendirildi. 4., 24. saat, 2,3,5,7, 10, 15 ve20. günlerde her defasında 2 deney, 2 kontrol gözü olmak üzere toplam 4 göz makroskobik, biomikroskobik ve fundus muayenelerinin yapılmasının ardından enükle edilerek histopatolojik inceleme uygulandı. Retinada lidokain toksititesine bağlı olabilecek histopatolojik bir bulgu gözlenmedi ancak bazı gözlerde proforasyona bağlı olarak gelişen değişiklikler saptandı.

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Cite This Article

ÜNLÜ, K., AKSÜNGER, A., YILMAZ, F., DURGUN, Y., KARAKAŞ, N., SÖKER, S. (2000). Histopathologic evaluation after intravitreal injection of lidocaine in albino rats. Retina-Vitreus, Cilt: 8 - Sayı: 2, 160–168. https://ajindex.com/articles/307833

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