Journals / Romatizma Dergisi / 2004 / Cilt: 19 - Sayı: 3

Evaluation of bone mineral density in patients with plaque psoriasis without arthropathy

Artropatisi olmayan plak tip psoriasis hastalarında kemik mineral yoğunluğunun değerlendirilmesi

Pages
147–151
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

As a result, this study indicoted that cortical or trabecular bone density was not affected in patients with moderate and severe plaque psoriasis without joint involvement.

📌 3 Key Takeaways

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Objective & Hypothesis:Psoriasis is a chronic, recurrent, inflammatory and hyperproliferative skin disease.
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Key Findings & Data:Osteoporosis is characterized by decrease of bone mineral density (BMD) and bone matrix.
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Conclusion & Impact:As a result, this study indicoted that cortical or trabecular bone density was not affected in patients with moderate and severe plaque psoriasis without joint involvement.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Eklemler · Psoriyazis · Kemik yoğunluğu

Abstract

Psoriasis is a chronic, recurrent, inflammatory and hyperproliferative skin disease. Osteoporosis is characterized by decrease of bone mineral density (BMD) and bone matrix. Reduced BMD is a major risk factor for osteoporotic fracture. The aim of this study is to investigate BMD (using Z score) in patients with moderate and severe plaque psoriasis without arthropathy. Forty-three patients (12 males, 31 females and mean age 38.2) diagnosed as plaque psoriasis without joint involvement and 30 healthy subjects (9 males, 21 females and mean age 38.6) were included to this study. BMD was measured with dual X-ray absorptiometry at the lumbar spine (L2-4), femur and left forearm of all patients and healthy subjects. There were no significant differences in the mean BMD of L2-4, femur and left forearm between patients and healthy subjects (for each region p>0.05). Both groups were divided into two subgroups according to the age of the subjects as a younger and older than 40-year-old. No significant differences were detected in comparisons between these subgroups (p>0.05). Furthermore, we have not found significant differences in BMD between patients and healthy subjects which were postmenopausal (p>0.05). As a result, this study indicoted that cortical or trabecular bone density was not affected in patients with moderate and severe plaque psoriasis without joint involvement.

Özet

Psoriasis kronik seyirli, tekrarlayıcı, inflamatuvar ve hiperproliferatif bir deri hastalığıdır. Osteoporoz kemik mineral yoğunluğu (KMY) ve kemik matriksinin birlikte kaybı ile karakterize bir hastalıktır. Azalmış KMY osteoporotik kırıklar için major bir risk faktörüdür. Bu çalışmanın amacı, eklem tutulumu olmayan orta ve şiddetli plak tip psoriasisli hastalarda KMY'nu (Z skoru kullanılarak) araştırmaktır. Eklem tutulumu olmayan plak tip psoriasis tanısı konulan 43 hasta (12 erkek, 31 kadın ve yaş ortalaması 38.3) ve 30 sağlıklı kişi (9 erkek, 21 kadın ve yaş ortalaması 38.6) çalışmaya kabul edildi. Tüm olguların ve sağlıklı kişilerin lomber (L2-4), femur ve sol önkol KMY'ları X-ray absorptiyometri ile ölçüldü. Hastaların L2-4, femur ve sol önkol ortalama KMY değerleri ile sağlıklı kişilerin L2-4, femur ve sol önkol ortalama KMY değerleri arasında anlamlı fark tespit edilmedi (her bölge için p>0.05). Her iki grup 40 yaş altı ve üstü olarak ikişer alt gruba ayrıldı ve alt gruplar arasında yapılan karşılaştırmalarda anlamlı fark saptanmadı (p>0.05). Ayrıca menapozda olan hastaların KMY ile menapozda olan sağlıklı kişilerin KMY arasında da anlamlı fark tespit edilmedi (p>0.05). Sonuç olarak, bu çalışma eklem tutulumu olmayan orta ve şiddetli plak tip psoriasisli hastalarda kortikal ve trabeküler kemik dansitesinin etkilenmediğini göstermektedir.

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Cite This Article

KOCA, R., ALTINYAZAR, H. C., KILINÇARSLAN, M. D., AÇIKGÖZ, G., KOÇ, Ü. (2004). Evaluation of bone mineral density in patients with plaque psoriasis without arthropathy. Romatizma Dergisi, Cilt: 19 - Sayı: 3, 147–151. https://ajindex.com/articles/306163

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