Effect of hormone replacement therapy on patella cartilage volume

Key Findings & Data:The patellar cartilage volumes of 23 non HRT user women (control group) and 21 HRT user women (less than 5 years), 15 HRT user women (more than 5 years) were calculated by means of magnetic resonance imaging (MRI).

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Conclusion & Impact:The data in this study indicates that especially long term HRT may have preventive effect on the patellar cartilage.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Postmenopoz · Hormon replasman tedavisi · Kıkırdak

Abstract

It has been shown that symptomatic knee osteoarthritis (OA) may often be related to patellofemoral OA. Patellofemoral OA is more common in women than men, suggesting that differences in sex hormones may modulate the disease. Although some epidemiological data suggests that hormone replacement therapy (HRT) has an effect on the incidence and prevalence of OA in postmenopausal women, little is known about the effect on patellofemoral OA. In this study, our aim was to determine the effect of HRT on patellar cartilage volumes in postmenopausal non HRT user (control group) and HRT user women. The patellar cartilage volumes of 23 non HRT user women (control group) and 21 HRT user women (less than 5 years), 15 HRT user women (more than 5 years) were calculated by means of magnetic resonance imaging (MRI). Statistical difference was found between the patellar cartilage volume measurement of HRT user (> 5 years) and non-user postmenopausal women (p=0.001). The data in this study indicates that especially long term HRT may have preventive effect on the patellar cartilage.

Özet

Semptomatik diz osteoartritinin (OA) sıklıkla patellofemoral OA ile ilişkili olabileceği gösterilmiştir. Patellofemoral OA'in kadınlarda erkeklerden daha fazla görülmesi seks hormonu farklılığının hastalık üzerinde etkili olabileceğini düşündürmektedir. Postmenopozal kadınlarda hormon replasman tedavisinin (HRT), OA insidans ve prevalansı üzerine etkili olduğunu destekleyen epidemiyolojik veriler olsa da HRT'nin patellofemoral OA üzerine etkisi tam olarak bilinmemektedir. Bu çalışmada amacımız; HRT almayan (kontrol) ve alan postmenopozal kadınlarda, HRT kullanımının patella kartilaj hacmi üzerine etkisini kartilaj hacmi ölçümü ile değerlendirmekti.HRT almamış 23 olgu (kontrol), 5 yıldan kısa süre HRT almış 21 olgu ve 5 yıldan uzun süre HRT almış 15 olgunun patella kartilaj hacimleri manyetik rezonans görüntüleme (MRG) yöntemi kullanılarak ölçüldü. HRT almayan kontrol grubu ile uzun süre (>5 yıl) HRT alan posimenopozal kadınların patella kartilaj hacimleri arasında istatistiksel olarak anlamlı fark bulundu (p= 0.001). Çalışma sonucu elde ettiğimiz veriler, özellikle uzun süre (>5 yıl) HRT kullanımının patella kartilajı üzerine koruyucu etkisi olabileceğini göstermektedir.

Keywords

Postmenopoz Hormon replasman tedavisi Kıkırdak Patella Osteoartrit Östrojenler Postmenopause Hormone Replacement Therapy Cartilage Osteoarthritis Estrogens

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Cite This Article

BAYSAL, Ö., ALTAY, Z. E., ÖNER, T., BAYSAL, T., BURAK, F., YOLOĞLU, S. (2005). Effect of hormone replacement therapy on patella cartilage volume. Romatizma Dergisi, Cilt: 20 - Sayı: 1, 9–13. https://ajindex.com/articles/305977

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