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Journals / Romatizma Dergisi / 2008 / Cilt: 23 - Sayı: 4

Fibromiyalji sendromlu premenopozal kadınlarda IGF-1 düzeyleri ve kemik mineral yoğunluğunun ilişkisi

Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome

Onur ARMAĞAN
Esra SIRMAGÜL
Ayşin EKİM
Başar SIRMAGÜL
Funda TAŞÇIOĞLU
Cengiz ÖNER
Pages
118–123
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusions: The results of the present study shows that routine BMD measurements should be done in premenopausal FMS patients, especially who have low levels of IGF-1.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The present study aims to compare bone mineral density (BMD) of healthy female patients with that of females with fibromyalgia syndrome (FMS), as well as to determine the relationship between insulin-like growth factor-1 (IGF-1) and BMD.
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Key Findings & Data:Materials and Methods: Twenty-seven premenopausal women with FMS and 21 age-matched female controls were included in the study.
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Conclusion & Impact:Conclusions: The results of the present study shows that routine BMD measurements should be done in premenopausal FMS patients, especially who have low levels of IGF-1.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kadın · Fibromiyalji · İnsülin-benzeri büyüme faktörü I

Abstract

Objective: The present study aims to compare bone mineral density (BMD) of healthy female patients with that of females with fibromyalgia syndrome (FMS), as well as to determine the relationship between insulin-like growth factor-1 (IGF-1) and BMD. Materials and Methods: Twenty-seven premenopausal women with FMS and 21 age-matched female controls were included in the study. Body mass index (BMI), IGF-1 and osteocalcin levels were assessed for all the cases. BMD measurements of the femoral neck and lumbar spine were done by using dual-energy X-ray absorptiometry. Results: Lomber and femoral bone mineral density were significantly lower in FMS patients compared with controls (p<0.001). Serum concentrations of IGF-1 were significantly lower in FMS than those in healthy females (p<0.01). There was a significant correlation between IGF-1 and BMD (trochanteric and lumbar spine) in FMS patients. No difference was found between the groups with respect to serum osteocalcine levels. Conclusions: The results of the present study shows that routine BMD measurements should be done in premenopausal FMS patients, especially who have low levels of IGF-1.

Özet

Amaç: Bu çalışmanın amacı, Fibromiyalji sendromlu (FMS) kadınlarla sağlıklı kadınların Kemik mineral yoğunluğunu (KMY) karşılaştırmak, aynı zamanda KMY ile insulin-like growth faktör-1 (IGF-1) arasındaki ilişkiyi tanımlamaktır. Yöntem ve Gereçler: Yirmi yedi premenopozal kadın ve aynı yaş grubunda 21 sağlıklı kadın çalışmaya alındı. Çalışmaya alınan tüm olguların vucüt kitle indeksleri (VKİ), IGF-1 ve osteokalsin düzeyleri değerlendirildi. Dual enerji X-Ray absorpsiyometri yöntemi ile femur boyun, trokanterik bölge ve lomber bölge (L 1-4 ön-arka) KMY ölçümleri yapıldı. Bulgular: Lomber ve femoral bölge KMY' ları kontrol grubu ile karşılaştırıldığında FMS' lu hastalarda anlamlı düzeyde azdı (p<0.001). IGF-1 serum konsantrasyonu FMS' lu kadınlarda sağlıklı kadınlardan önemli derecede daha düşük düzeyde idi (p<0.001). Fibromyalji sendromlu hasta grubunda IGF-1 ile KMY (trokanterik ve lomber bölge) arasında anlamlı pozitif bir korelasyon vardı. Gruplar arasında serum osteoklasin düzeyleri farklı bulunmadı. Sonuç: Bu çalışmanın sonuçları özellikle düşük IGF-1 düzeyine sahip premenopozal FMS' lu hastalarda rutin KMY ölçümlerinin yapılması gerektiğini gösterdi

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Cite This Article

ARMAĞAN, O., SIRMAGÜL, E., EKİM, A., SIRMAGÜL, B., TAŞÇIOĞLU, F., ÖNER, C. (2008). Fibromiyalji sendromlu premenopozal kadınlarda IGF-1 düzeyleri ve kemik mineral yoğunluğunun ilişkisi. Romatizma Dergisi, Cilt: 23 - Sayı: 4, 118–123. https://ajindex.com/articles/305897

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References (15)

  1. Wolfe F, Ross K, Anderson, Russel IJ, Hebert L. The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum 1995; 38: 19-28
  2. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bomberdic C, Goldenberg DL, et al. The American College of Rheumatology 1990: criteria for the classification of fibromyalgia: Report of the Multi-Center Criteria Committee. Arthritis Rheum 1990; 33: 160-72
  3. Lawrence RC, Helmick CG, Arnett FC, Deyo Ra, Felson DT, Giannini EH, et al. Estimate of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 1998; 41: 778-99
  4. Leal-Cerro A, Povedan J. Astorga OR, Gonzalez M, Silva H, and Garcia-Pesquera F. The growth hormone (GH)-releasing hormone-GH-insulin-like growth factor-1 axis in patients with fibromyalgia syndrome, J Clin Endocrinol Metab 1999; 84:3378-81
  5. Landis CA, Lentz MJ, Rothermel J, Riffle SC, Chapman D, and Buchwald D, et al., Decreased nocturnal levels of prolactin and growth hormone in women with fibromyalgia, J. Clin. Endocrinol. Metab 2001; 86: 1672-8
  6. Clauw DJ. The pathogenesis of chronic pain and fatigue syndromes, with special reference to fibromyalgia, Med. Hypotheses 1995; 44: 369-78
  7. Crofford LJ. Pillemer SR, Kalogeras KT, Cash JM, Michelson D, Kling MA, et al., Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia, Arthritis Rheum 1994; 37: 1583-92
  8. Crofford, LJ. Neuroendocrine abnormalities in fibromyalgia and related disorders, Am. J. Med. Sci 1998; 315: 359-66
  9. Bennett RM. Disordered growth hormone secretion in fibromyalgia: a review of recent findings and a hypothesized etiology, Z. Rheumatol 1998; 57 (Suppl. 2): 72-6
  10. Blum WF, Albertsson-Wikland K, Rosberg S,Ranker MB. Serum levels of insulin growth factor 1 (IGF 1) and IGF-1 binding protein 3 reflect spontaneous growth hormone secretion. Acta Endocrinol Metab 1993; 76: 1610-6
  11. Bennett RM. Adult growth hormone in patients fibromyalgia. Curr Rheumatol Rep 2002; 306-12
  12. Bonjour JP, Schurch MA, Chevalley T, Ammann P, Rizolli R. Protein intake. IGF-1 and osteoporosis. Osteoporosis Int 1997; 7: 36-42
  13. Bagge E, Bengtsson BA, Carlsson L, and Carlsson J. Low growth hormone secretion in patients with fibromyalgia-a preliminary report on 10 patients and 10 controls, J. Rheumatol 1998; 25: 145-8
  14. Bennett RM. Adult growth hormone deficiency in patients with fibromyalgia, Curr Rheumatol Rep 2002; 4: 306-12
  15. Moldofsky H, Scaris