Journals / Retina-Vitreus / 2004 / Cilt: 12 - Sayı: 2

Serum ascorbic acid, zinc and copper levels in age related macular degeneration

Yaşa bağlı makula dejenerasyonunda serum askorbik asit, çinko ve bakır seviyeleri

Pages
108–111
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Because of the possible toxic effects and complications of oral zinc administration, widespread use of zinc in ARMD is now not warranted.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: To evaluate the relation between blood antioxidant levels and exudative age related macular degeneration (ARMD) Materials and Methods: Twenty-three patients of exudative ARMD were included in the study.
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Key Findings & Data:As a control group, 23 patients presented to our clinic for the examination of refraction were also evaluated.
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Conclusion & Impact:Because of the possible toxic effects and complications of oral zinc administration, widespread use of zinc in ARMD is now not warranted.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Askorbik asit · Çinko · Bakır

Abstract

Purpose: To evaluate the relation between blood antioxidant levels and exudative age related macular degeneration (ARMD) Materials and Methods: Twenty-three patients of exudative ARMD were included in the study. As a control group, 23 patients presented to our clinic for the examination of refraction were also evaluated. Antecubital venous blood samples were taken in all patients to investigate serum ascorbic acid, zinc and copper levels with spectrophotometric methods. Measurements of best corrected visual acuity, slit-lamp examination and applanation tonometry were performed for each subject. All of data were compared statistically using the student-t test. Results: The ARMD group included 12 males, 11 females and the control group 10 males, 13 females. The ARMD group ranged between 55-83 years (mean 71,78±7,43) and the control group between 33-78 (mean 55,61±15,96). The difference between the levels of ascorbic asid, zinc and copper was not statistically significant between the two groups. Conclusion: All persons should be encouraged to maintain health nutrition. Middle-aged and elderly patients may benefit from a supplement. An intake in excess of the recommended daily intake may be benefical but this is not proven. Because of the possible toxic effects and complications of oral zinc administration, widespread use of zinc in ARMD is now not warranted.

Özet

Amaç: Eksudatif tip yaşa bağlı makula dejenerasyonu (YBMD) ile serum antioksidan vitamin ve mineralleri arasındaki ilişkiyi araştırmak. Gereç ve Yöntem: Çalışmaya eksudatif YBMD tanısı almış 23 hasta dahil edildi. Kontrol grubu, refraksiyon muayenesi için polikliniğe başvuran 23 kişiden oluşturuldu. Tüm hastalardan, antekubital venöz kan örneği alınarak serum askorbik asit, çinko ve bakır seviyeleri spektrofotometrik yöntem ile saptandı. Hasta ve kontrol grubunun düzeltilmiş görme keskinlikleri saptandı, biyomikroskop ile ön segment ve fundus muayeneleri yapıldı ve aplanasyon tonometresi ile göz içi basınçları saptandı. İstatistiksel analiz için student-t testi kullanıldı. Bulgular: Hasta grubu 12 erkek, 11 kadın ve kontrol grubu 10 erkek ve 13 kadından oluşmaktaydı. Hasta grubunun yaşları 55-83 (ortalama 71,78±7,43) arasında değişirken, kontrol grubunun yaşları 33-78 (ortalama 55,61±15,96) arasında idi. Hasta ve kontrol grubunun askorbik asit, çinko ve bakır serum seviyeleri karşılaştırıldığından istatistiksel açıdan anlamlı fark saptanmadı. Sonuç: Tüm bireyler sağlıklı beslenme için teşvik edilmelidir. Orta yaş ve ileri yaştaki hastalar vitamin ve mineral takviyesinden fayda görebilir. Yüksek doz vitamin ve mineral alımının faydalı olacağı ifade edilse de bu tam olarak aydınlatılamamıştır. Oral çinko alımı toksik etkileri ve komplikasyonları olabileceğinden YBMD'da garantili olmayabilir

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Cite This Article

UÇGUN, N. İ., YILDIRIM, Z., FİKRET, C. Z., ÖZEL, Ü., GÜRSEL, E. (2004). Serum ascorbic acid, zinc and copper levels in age related macular degeneration. Retina-Vitreus, Cilt: 12 - Sayı: 2, 108–111. https://ajindex.com/articles/305277

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