Journals / Retina-Vitreus / 2008 / Cilt: 16 - Sayı: 3

Polimeraz zincir reaksiyonunun tanısal değeri: Atipik bir herpetik arka üveit olgusu

The value of polymerase chain reaction in a diagnostic challenge: An atypical posterior herpetic uveitis

Pages
233–235
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

HSV may play an important role in nonspecific, atypical ocular inflammations and the existence of HSV-DNA can be detected in ocular fluids and membranes with PCR, which can serve as an exceptionally valuable diagnostic tool for HSV infections.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:An atypical posterior uveitis caused by Herpes Simplex Virus (HSV) is presented in this case report.
📊
Key Findings & Data:Visual acuity improved from finger counting to 20/30 after vitrectomy and intravenous acyclovir therapy.
💡
Conclusion & Impact:HSV may play an important role in nonspecific, atypical ocular inflammations and the existence of HSV-DNA can be detected in ocular fluids and membranes with PCR, which can serve as an exceptionally valuable diagnostic tool for HSV infections.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Üveit · Erişkin · Kadın

Abstract

An atypical posterior uveitis caused by Herpes Simplex Virus (HSV) is presented in this case report. Initially no specific etiology could be specified and posterior segment findings were progressive despite oral steroid therapy. Thereafter, a diagnostic vitrectomy was performed and polymerase chain reaction (PCR) for HSV-DNA was found to be positive in the vitreous sample. Visual acuity improved from finger counting to 20/30 after vitrectomy and intravenous acyclovir therapy. HSV may play an important role in nonspecific, atypical ocular inflammations and the existence of HSV-DNA can be detected in ocular fluids and membranes with PCR, which can serve as an exceptionally valuable diagnostic tool for HSV infections.

Özet

Bu çalışmada, herpes simpleks virüsün (HSV) neden olduğu atipik bir arka üveit sunulmaktadır. Başlangıçta, üveitin spesifik bir etiyoloji saptanamamış ve ampirik olarak oral steroid tedavisi başlanmıştır. Ancak, arka segment bulgularının ilerleyici olması nedeniyle tanısal bir vitrektomi yapılmış ve alınan vitre örneklerinde HSV-DNA’sı polimeraz zincir reaksiyonu (PCR) ile saptanabilmiştir. Vitrektomi sonrası intravenöz asiklovir tedavisi de başlanmış ve hastanın başlangıçta parmak sayma düzeyinde olan görme keskinliği 20/30’a kadar yükselmiştir. HSV, atipik oküler inflamasyonlarda önemli bir role sahip olabilir. Oküler sıvı örneklerinde veya membran gibi oküler doku örneklerinde HSV-DNA’sının PCR ile saptanması mümkündür. PCR’nin, atipik herpetik üveitlerin tanısında çok değerli bir araç olduğu düşünülmektedir.

🔖

Cite This Article

AYDIN, B., HONDUR, A., GÜRELİK, G., ÇIRAK, Y. M., HASANREİSOĞLU, B. (2008). Polimeraz zincir reaksiyonunun tanısal değeri: Atipik bir herpetik arka üveit olgusu. Retina-Vitreus, Cilt: 16 - Sayı: 3, 233–235. https://ajindex.com/articles/305241

References (15)

  1. Green LK, Pavan-Langston D.: Herpes simplex ocular inflammatory disease. Int Ophthalmol Clin. 2006;46:27-37
  2. Elkins BS, Holland GN, Opremcak EM, et al.: Ocular toxoplasmosis misdiagnosed as cytomegalovirus retinopathy in immunocompromised patients. Ophthalmology. 1994;101:499-507
  3. Cubillan LD, Cubillan EA, Berger TG, et al.: Syphilitic uveitis and dermatitis. Arch Ophthalmol. 1998;116:696-697
  4. Mendelsohn AD, Jampol LM.: Syphilitic retinitis. A cause of necrotizing retinitis. Retina. 1984;4:221-224
  5. Duker JS, Nielsen JC, Eagle RC Jr, et al.: Rapidly progressive acute retinal necrosis secondary to herpes simplex virus type 1. Ophthalmology. 1990;97:1638-1643
  6. Chiquet C, Bodaghi B, Mougin C, et al.: Acute retinal necrosis diagnosed in a child with chronic panuveitis. Graefes Arch Clin Exp Ophthalmol. 2006;244:1206-1208
  7. Rummelt V, Rummelt C, Jahn G, et al.: Triple retinal infection with human immunodeficiency virus type 1, cytomegalovirus, and herpes simplex virus type 1. Light and electron microscopy, immunohistochemistry, and in situ hybridization. Ophthalmology. 1994;101:270-279
  8. Freeman WR, Stern WH, Gross JG, et al.: Pathologic observations made by retinal biopsy. Retina. 1990;10:195-204
  9. Yamamoto S, Pavan-Langston D, Kinoshita S, et al.: Detecting herpesvirus DNA in uveitis using the polymerase chain reaction. Br J Ophthalmol. 1996;80:465-468. 10. de Boer JH, Verhagen C, Bruinenberg M, et al.: Serologic and polymerase chain reaction analysis of intraocular fluids in the diagnosis of infectious uveitis. Am J Ophthalmol. 1996;121:650-658
  10. Knox CM, Chandler D, Short GA, et al.: Polymerase chain reaction-based assays of vitreous samples for the diagnosis of viral retinitis. Use in diagnostic dilemmas. Ophthalmology. 1998;105:37-44
  11. Westeneng AC, Rothova A, de Boer JH, et al.: Infectious uveitis in immunocompromised patients and the diagnostic value of polymerase chain reaction and Goldmann-Witmer coefficient in aqueous analysis. Am J Ophthalmol. 2007;144:781-785
  12. Chan CC, Shen D, Tuo J.: Polymerase chain reaction in the diagnosis of uveitis. Int Ophthalmol Clin. 2005;45:41-55
  13. Madhavan HN, Priya K, Biswas J.: Current perspectives of herpesviral retinitis and choroiditis. Indian J Pathol Microbiol. 2004;47:453-468
  14. Rothova A, de Boer JH, Ten Dam-van Loon NH, et al.: Usefulness of Aqueous Humor Analysis for the Diagnosis of Posterior Uveitis. Ophthalmology. 2007 Jul 30; [Epub ahead of print]
  15. Lau CH, Missotte