Journals / Retina-Vitreus / 2008 / Cilt: 16 - Sayı: 1

Central macular function evaluation in intermediate age-related macular degeneration by fundus autofluorescence and preferential hyperacuity perimetry

İntermediate yaşa bağlı makula dejenerasyonunda fundus otofloresansı ve preferential hiperakuite perimetri ile makula fonksiyonunun değerlendirilmesi

Pages
15–20
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

FAF and PHP appear to be effective for demonstrating central macular dysfunction in intermediate AMD.

📌 3 Key Takeaways

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Objective & Hypothesis:To evaluate central macular function by fundus autofluorescence (FAF) and preferential hyperacuity perimetry (PHP) in intermediate age-related macular degeneration (AMD).
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Key Findings & Data:Central 14°x14° visual field was tested with PHP (Foresee PHP Notalvision). , A hyperacuity deviation map and hyperacuity defect maps were recorded by PHP.
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Conclusion & Impact:FAF and PHP appear to be effective for demonstrating central macular dysfunction in intermediate AMD.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Floresan anjiyografi · Maküler dejenerasyon · Görme alanları

Abstract

To evaluate central macular function by fundus autofluorescence (FAF) and preferential hyperacuity perimetry (PHP) in intermediate age-related macular degeneration (AMD). Materials and Methods: Patients diagnosed with intermediate AMD were evaluated by FAF, fundus fluorescein angiography, and optical coherence tomography (OCT) after a detailed ophthalmic examination. Central 14°x14° visual field was tested with PHP (Foresee PHP Notalvision). , A hyperacuity deviation map and hyperacuity defect maps were recorded by PHP. Patients having high false positive or false negative ratios in PHP were excluded. The correlation between the FAF and PHP findings was also investigated. Results: Fifteen eyes of 15 patients with a mean age of 69.1±5.6 years and a mean visual acuity of 0.8±0.05 were included. Mean macular thickness was 173.9±30.2 μm by OCT. Significant scotoma in 11 eyes was detected in the hyperacutiy deviation map by PHP; however, in 4 eyes the hyperacuity deviation map was entirely normal. Estimated retinal lesions in the hyperacuity defect map demonstrated by PHP matched the increased autofluorescence areas by FAF. Conclusion: In the majority of cases increased autofluorescence areas were correlated to estimated retinal localizations detected by PHP. FAF and PHP appear to be effective for demonstrating central macular dysfunction in intermediate AMD.

Özet

İntermediate yaşa bağlı makula dejenerasyonu (YBMD) saptanan olgularda fundus otofloresansı (FAF) ve prefe- rential hiperakuite perimetri (PHP) ile santral makula fonk- siyonunun değerlendirilmesi. Gereç ve Yöntem: İntermediate YBMD tanısı konulan hastalar detaylı oftalmolojik muayene sonrasında FAF, fundus flo- resan anjiografi ve optik koherens tomografi (OKT) ile de- ğerlendirildiler. Tüm olgularda santral 14°x14°’lik görme alanı PHP (Foresee PHP Notalvision) ile incelendi. PHP ile , hiperakuite deviasyon haritası ve hiperakuite defekt harita- ları kaydedildi. PHP’de yanlış pozitif ve yanlış negatif yüz- deleri güvenilir olmayan olgular çalışma dışında bırakıldı. FAF ve PHP bulguları arasındaki ilişki incelendi. Bulgular: Ortalama yaşları 69.1±5.6 yıl olan 8’i kadın, 12’si erkek toplam 15 hastanın 20 gözü çalışma kapsamına alındı. Olguların ortalama görme keskinliği 0.8±0.05 olup OKT ile belirlenen ortalama makula kalınlığı 173.9±30.2 μm idi. Değerlendirmeye alınan 11 gözde PHP ile hipera- kuite deviasyon haritasında belirgin skotom saptanırken, 4 gözde hiperakuite deviasyon haritası tamamen normal olarak bulundu. PHP’de skotom saptanan 11 gözde hi- perakuite defekt haritasındaki tahmini retina lezyonu yer- leşimlerinin FAF’de görülen artmış otofloresans gösteren lezyonlar ile örtüştüğü gözlendi. Sonuç: İntermediate YBMD olgularında FAF’daki artmış otof- loresans alanlarının PHP’de saptanan tahmini retina loka- lizasyonları ile büyük oranda örtüştüğü izlenmiştir. FAF ve PHP intermediate YBMD olgularında gelişen santral ma- , kula fonksiyon bozukluğunu belirlemede çoğunlukla etkin olabilmektedir.

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Cite This Article

YENEREL, N. M., DİNÇ, U. A., GÖRGÜN, E., ÖNCEL, M., BAŞAR, D. (2008). Central macular function evaluation in intermediate age-related macular degeneration by fundus autofluorescence and preferential hyperacuity perimetry. Retina-Vitreus, Cilt: 16 - Sayı: 1, 15–20. https://ajindex.com/articles/305225

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