Journals / Retina-Vitreus / 2009 / Cilt: 17 - Sayı: 2

Intravitreal injection treatment in two cases with radiation retinopathy

Radyasyon retinopatili iki olguda intravitreal enjeksiyon tedavisi

Pages
136–140
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There is no consensus on treatment of radiation retinopathy but intravitreal injections may limit the damage and have a role in the treatment of macular oedema due to radiation retinopathy.

📌 3 Key Takeaways

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Objective & Hypothesis:Medical records of two patients treated for radiation retinopathy in our clinic were evaluated retrospectively to assess the efficacy of various intravitreal injections.
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Key Findings & Data:Age of the patients was 28 and 53.
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Conclusion & Impact:There is no consensus on treatment of radiation retinopathy but intravitreal injections may limit the damage and have a role in the treatment of macular oedema due to radiation retinopathy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Orta yaşlı · Radyasyon hasarı · Triamsinolon asetonit

Abstract

Medical records of two patients treated for radiation retinopathy in our clinic were evaluated retrospectively to assess the efficacy of various intravitreal injections. Age of the patients was 28 and 53. The time interval between radiotherapy and radiation retinopathy was 3 years in the first patient and one year in the second. First patient received no prior treatment. Second patient had a history of left vitrectomy for a presumed diagnosis of retinal vein occlusion at another institute. First patient’s visual acuity was 2/10 in the right eye and 4/10 in the left eye while second petient’s visual acuity was counting fingers at 2 meters in the right eye and counting fingers at 4 meters in the left eye. Their posterior segment examinations revealed changes compatible with radiation retinopathy. There was no retinal or disc neovascularization. Second patient had also signs of optic neuropathy in the left eye. Both patients had multiple intravitreal injections of triamcinolone acetonide, bevacizumab and pegaptanib sodium. Early after injections visual acuity and clinic manifestations became slightly better but re-injections deemed necessary due to recurrent macular oedema. There is no consensus on treatment of radiation retinopathy but intravitreal injections may limit the damage and have a role in the treatment of macular oedema due to radiation retinopathy.

Özet

Radyasyon retinopatisinde, intravitreal enjeksiyon tedavisinin sonuçlarını değerlendirmek amacıyla kliniğimizde tedavi edilen iki hastanın kayıtları retrospektif olarak incelendi. Hastaların yaşları 28 ve 53’tü. Radyoterapi ile radyasyon retinopatisi ortaya çıkması arasında geçen süre ilk hastada 3 yıl, ikinci hastada ise 1 yıldı. İlk hastamız herhangi bir tedavi görmemişken, ikinci hastamız dış merkezde sol gözünden santral retinal ven oklüzyonu sanılarak vitrektomi cerrahisi geçirmişti. Görme keskinliği ilk hastada sağda 2/10 solda 4/10, ikinci hastada ise sağda 4 mps, solda 2 mps olarak ölçüldü. Fundus muayenesinde her iki hastada da radyasyon retinopatisi ile uyumlu değişiklikler vardı. Disk veya retina neovaskülarizasyonu gözlenmedi. İkinci hastada ilave olarak solda optik nöropati bulguları vardı. Her iki hastaya da triamsinolon asetonid, bevacizumab ve pegaptanib sodyum olmak üzere çoklu intravitreal enjeksiyonlar uygulandı. Tedavi sonrası erken dönemde görme keskinlikleri ve klinik görünümde düzelme izlenirken, zamanla maküla ödemindeki nüks nedeniyle her iki hasta da enjeksiyonların tekrarlanması ihtiyacı ortaya çıktı. Radyasyon retinopatisi tedavisinde halen bir fikir birliği yoksa da intravitreal enjeksiyonlar hastalığın şiddetini geçici olarak da olsa azalttıkları için, maküla ödemi tedavisinde bir role sahip olabilir.

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Cite This Article

SELVER, Ö. B., YAMAN, A., ÖNER, F. H., SÖYLEV, M. F., SAATCİ, A. O. (2009). Intravitreal injection treatment in two cases with radiation retinopathy. Retina-Vitreus, Cilt: 17 - Sayı: 2, 136–140. https://ajindex.com/articles/305146

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