Journals / Retina-Vitreus / 2017 / Cilt: 26 - Sayı: 1

Visual Prognosis and Risk Factors in Patients with Uveitis Associated with Ankylosing Spondylitis

Ankilozan Spondilit ile İlişkili Üveit Olgularının Görsel Prognozu ve Risk Faktörleri

Pages
46–52
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The recurrence was higher in women than in men.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: To examine factors affecting visual prognosis and recurrence in patients having uveitis associated with ankylosing spondylitis (AS).
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Key Findings & Data:Methods: Thirty-five eyes of 26 patients with uveitis associated with ankylosing spondylitis were evaluated, retrospectively.
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Conclusion & Impact:The recurrence was higher in women than in men.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: To examine factors affecting visual prognosis and recurrence in patients having uveitis associated with ankylosing spondylitis (AS). Methods: Thirty-five eyes of 26 patients with uveitis associated with ankylosing spondylitis were evaluated, retrospectively. Clinical and laboratory findings of patients at time of diagnosis possibly affecting visual outcome and recurrence were analyzed.Results: The mean follow-up period was 33.1 ± 32.7 months, baseline best corrected visual acuity (BCVA) (logMAR) was 0.33 ± 0.45, final BCVA was 0.22 ± 0.39 (p=0.02). The final BCVA (logMAR) in eyes with baseline legal blindness and cataracts was significantly higher than those without them (p<0.05). However, final BCVA was similar in males and females, in patients with unilateral or bilateral involvement, and with or without a family history, history of unilateral variable or recurrent uveitis, baseline glaucoma, macular edema or recurrence (p>0.05). The positive correlation was also detected between final and baseline BCVA (r = 0.73, p<0.001), while there was no correlation between final BCVA and age of first symptoms, time between AS and uveitis, attack duration, C-reactive protein and erythrocyte sedimentation rate, anterior chamber cell and vitreous hazy levels. When all these factors were examined in terms of recurrence; the recurrence was only affected by gender and it was higher in women than in men (70.6%vs. 33.3%, p=0.028).Conclusion: The final BCVA in patients with uveitis associated with AS was just correlated with the baseline BCVA and influenced by baseline legal blindness and cataract. The recurrence was higher in women than in men.

Özet

Amaç: Ankilozan spondilit (AS) ile ilişkili üveit olgularının görsel prognoza ve nüks gelişimi üzerine etki eden faktörlerini incelemek.Gereç ve Yöntem: Ankilozan spondilit ile ilişkili üveit tanısı almış 26 hastanın 35 gözü retrospektif olarak incelendi. Hastaların tanı anındaki klinik ve laboratuar bulgularının görsel prognoza ve nüks gelişimi üzerine olası etkileri araştırıldı.Bulgular: Olguların ortalama takip süresi ise 33.1±32.7 ay olup, başlangıç en iyi düzeltilmiş görme keskinliği (EİDGK) (logMAR) 0.33±0.45 iken, sonuç EİDGK 0.22±0.39 idi (p=0.02). Sonuç EİDGK (logMAR), başlangıçta legal körlüğü ve kataraktı olanlarda, olmayanlara göre anlamlı daha yüksekti (p 0.05). Sonuç EİDGK ile başlangıç EİDGK arasında pozitif korelasyon saptanırken (r=0.73, p<0.001); sonuç EİDGK ile ilk semptom yaşı, ankilozan spondilit ile üveit arasındaki süre, atak süresi, C-reaktif protein ve eritrosit sedimentasyon hızı değerleri, ön kamarada hücre ve vitreusta bulanıklık seviyesi arasında korelasyon yoktu. Nüks açısından tüm bu faktörler incelendiğinde; nüks sadece cinsiyetten etkilenmekteydi ve kadınlarda erkeklerden anlamlı daha yüksekti (%70.6 vs. %33.3, p=0.028). Sonuç: AS ile ilişkili üveit olgularında sonuç EİDGK; sadece başlangıç EİDGK ile korele olup, başlangıçta legal körlük ve katarakt varlığından etkilenmektedir. Nüks ise kadınlarda daha fazladır.

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Cite This Article

YILMAZ, M. B., İMRE, S. S., AYDIN, E., KAZANCI, L., KÖSE, T. (2017). Visual Prognosis and Risk Factors in Patients with Uveitis Associated with Ankylosing Spondylitis. Retina-Vitreus, Cilt: 26 - Sayı: 1, 46–52. https://ajindex.com/articles/304936

References (17)

  1. Gouveia EB, Elmann D, Morales MS. Ankylosing spondylitis and uveitis: overview. Rev Bras Reumatol 2012
  2. 56 2. Kotaniemi K, Aho K, Kotaniemi A. Uveitis as a cause of visual loss in arthritides and comparable conditions. J Rheumatol 2001
  3. 12 3. Brewerton DA, Hart FD, Nicholls A, et al. Ankylosing spondylitis and HLA-B27. Lancet 1973
  4. 7 4. Ji SX, Yin XL, Yuan RD, et al. Clinical features of ankylosing spondylitis associated with acute anterior uveitis in Chinese patients. Int J Ophthalmol 2012
  5. 6 5. Jabs DA. Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop. Am J Ophthalmol 2005
  6. 16 6. Jimenez-Balderas FJ, Mintz G. Ankylosing spondylitis: clinical course in women and men. J Rheumatol 1993
  7. 72 7. Sampaio-Barros PD, Conde RA, Bonfiglioli R, et al. Characterization and outcome of uveitis in 350 patients with spondyloarthropathies. Rheumatol Int 2006
  8. 6 8. Lee W, Reveille JD, Davis JC Jr, et al. Are there gender differences in severity of ankylosing spondylitis? Results from the PSOAS cohort. Ann Rheum Dis 2007
  9. 8 9. Monnet D, Breban M, Hudry C, Dougados M, Brezin AP. Ophthalmic findings and frequency of extraocular manifestations in patients with HLA-B27 uveitis: a study of 175 cases. Ophthalmology 2004
  10. 9 10. Will R, Edmunds L, Elswood J, et al. Is there sexual inequality in ankylosing spondylitis? A study of 498 women and 1202 men. J Rheumatol 1990
  11. 52 11. Braakenburg AM, de Valk HW, de Boer J, et al. Human leukocyte antigen-B27-associated uveitis: long-term follow-up and gender differences. Am J Ophthalmol 2008
  12. 9 12. Smith WM. Gender and spondyloarthropathy-associated uveitis. J Ophthalmol 2013
  13. 928264 13. Chung YM, Liao HT, Lin KC, et al. Prevalence of spondyloarthritis in 504 Chinese patients with HLA-B27-associated acute anterior uveitis. Scand J Rheumatol 2009
  14. 90 14. Moorthy RS, Rao PK, Read RW, et al. Chapter 6: Noninfectious (Autoimmune) Ocular Inflammatory Disease. Basic and Clinical Science Course. Section 9: Intraocular Inflammation and Uveitis. American Academy of Ophthalmology. Singapore 2011- 2012
  15. 196 15. Tay-Kearney ML, Schwam BL, Lowder C, et al. Clinical features and associated systemic diseases of HLA-B27 uveitis. Am J Ophthalmol 1996
  16. 56 16. Rothova A, van Veenedaal WG, Linssen A, et al. Clinical features of acute anterior uveitis. Am J Ophthalmol 1987
  17. 45 17. Kavuncu S, Taşkıntuna