Journals / Retina-Vitreus / 2017 / Cilt: 26 - Sayı: 2

Evaluation of The Fundus Findigs in Women With Polycystic Ovary Syndrome

Polikistik Over Sendromu Tanılı Hastalarda Fundus Bulgularının Değerlendirilmesi

Pages
117–121
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Choroidal as well as RNFL thickness measurements were increased in patient with PCOS.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: This study aimed to investigate the fundus fi ndings in women with polycystic ovary syndrome (PCOS) and to compare them with those of healthy reproductive-age women volunteers.Materials and Methods: The study included 50 eyes of 50 women (Group 1) with PCOS and 50 eyes of 50 healthy women (Group 2).
📊
Key Findings & Data:Results: The mean age of group 1 was 27 ± 4,18 years (min:19, max: 30) and group 2 was 26,4± 3,78 years (min:18, max:30).
💡
Conclusion & Impact:Choroidal as well as RNFL thickness measurements were increased in patient with PCOS.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: This study aimed to investigate the fundus fi ndings in women with polycystic ovary syndrome (PCOS) and to compare them with those of healthy reproductive-age women volunteers.Materials and Methods: The study included 50 eyes of 50 women (Group 1) with PCOS and 50 eyes of 50 healthy women (Group 2). In all subjects, the RNFL and choroidal thickness measurements were done using spectral domain optical coherence tomography (OCT) .Correlations between serum hormone (östradiol and testosteron) levels and observed fi ndings were also investigated. Results: The mean age of group 1 was 27 ± 4,18 years (min:19, max: 30) and group 2 was 26,4± 3,78 years (min:18, max:30). In PCOS group the average RNFL thickness in all quadrants except temporal quadrant (p=0.572) were higher than that of the control group. Mean subfoveal choroidal thickness in group 1 was 407,54±45,56 ?m and in group 2 was 320,72±26,12 ?m. Mean values of choroidal thickness was signifi cantly higher in the PCOS group (p=0.001). Serum östradiol level was moderately correlated with the choroidal thicknesses (r=+0.539). To evaluate the correlations between östradiol level and RNFL, the highest correlation was in RSLTn (r: 0,502) and RSLTin (r: 0,566). Serum free testosteron levels were moderately correlated with choroidal thickness (r=+0.664) . Serum testosteron levels were weakly correlated with RSLTt, RSLTst, RSLTsn, RSLTit and moderately correlated with RSLTin and RSLTn.Conclusion: PCOS leads to physiological and structural changes in the eye. Choroidal as well as RNFL thickness measurements were increased in patient with PCOS.

Özet

Amaç: Çalışmamızda Polikistik over sendromu (PKOS) tanılı hastaların fundus bulgularını değerlendirmeyi amaçladık. Değerlendirilen bulguların hormon düzeyleri ile korelasyonunu inceledik.Gereç- Yöntem: Çalışmamıza 50 PKOS (Grup 1) tanılı ve 50 sağlıklı gönüllünün (Grup 2) sağ gözleri dahil edildi. Tüm olgulara OKT ile subfoveal koroid ve peripapiller retina sinir lifi tabakası kalınlıkları değerlendirildi. PKOS tanılı hastaların bulgularının östradiol ve testosteron düzeyleri korelasyonu değerlendirildiBulgular: PKOS grubunda yaş ortalaması 27 ± 4,18 yıl (min:19, max: 30) , kontrol grubunda yaş ortalaması 26,4± 3,78(min:18, max:30) yıl idi. Retinal sinir lifi tabakası (RSLT) kalınlığı PKOS grubunda kontrol grubuna göre RSLTt dışında (p=0.572) tüm kadranlarda istatistiksel olarak anlamlı yüksek bulundu. Grup 1'de ortalama subfoveal koroid kalınlığı 407,54±45,56 ?m, Grup 2'de 320,72±26,12 ?m saptandı. PKOS hastalarında koroid kalınlığının kontrol gubuna göre istatistiksel olarak anlamlı derecede artış gösterdiği görüldü (p=0,001).Serum östradiol düzeyleri ile koroid kalınlığı arasında (r=0539) pozitif yönde orta düzey korelasyon saptandı. östradiol düzeyleri ile RSLT arasındaki korelasyonlara bakıldığında en yüksek korelasyon RSLTn (r= 0,502) ve RSLTin (r=0,566) arasında saptandı.Testosteron düzeyleri ile subfoveal koroid kalınlığı arasında pozitif yönde orta düzey korelasyon saptandı. (r=0,664). serum Testosteron düzeyleri ile RSLT arasındaki korelasyonlara bakıldığında RSLTt, RSLTst, RSLTsn, RSLTit , RSLTort arasında pozitif yönde zayıf korelasyon, RSLTin ve RSLTn arasında pozitif yönde orta korelasyon görüldü.Sonuç: PKOS göz dokularında fi zyolojik ve yapısal değişikliklere yol açmaktadır. Retina sinir lifi tabakası ve koroid kalınlıklarının PKOS tanılı hastalarda artmış olduğu görüldü. Serum testosteron ve östradiol düzeyleri ile bulguların korele olduğu izlendi.

🔖

Cite This Article

KARACA, S. A., KARACA, İ., ADIYEKE, M., YILDIRIM, S., TÜRE, G. (2017). Evaluation of The Fundus Findigs in Women With Polycystic Ovary Syndrome. Retina-Vitreus, Cilt: 26 - Sayı: 2, 117–121. https://ajindex.com/articles/304873

References (10)

  1. Carmina E, Lobo RA. PCOS: arguably the most common endocrinopathy is associated with signifi cant morbidity in women. J. Clin Endocrinol Metabol. 1999;84: 1897-9
  2. Lang Y, Lang N, Ben-Ami M, Garzozi H. The effects of hormone replacement therapy (HRT) on the human eye. Harefuah. 2002; 141(3):287-291
  3. Behl C, Widmann M, Trapp T, Holsboer F. 17-Beta östradiol protects neurons from oxidative stressinduced cell death in vitro. Biochem Biophys Res Commun 1995;216(2):473-82
  4. Vingerling JR, Dielemans I, Witteman JC, Hofman A, Grobbee DE, de Jong PT. Macular degeneration and early menopause: a case-control study. BMJ 1995;310(6994):1570-1
  5. Yucel I, Akar ME, Dora B, Akar Y, Taskın O, Ozer HO. Effect of the menstrual cycle on Standard achromatic and blue-on-yellow visual fi eld analysis of womwn with migraine. Can ophthalmol. 2005;40(1):51-7
  6. Ogueta SB, Schwartz SD, Yamashita CK, Farber DB. Estrogen receptor in the human eye: infl uence of gender and age on gene expression.Invest Ophthalmol Vis Sci 1999;40(9):1906-11
  7. Parvathaneni K, Grigsby JG, Betts BS, Tsin AT. Estrogen-induced retinal endothelial cell proliferation: possible involvement of pigment epithelium-derived factor and phosphoinositide 3-kinase/mitogen-activated protein kinase pathways. J Ocul Pharmacol Ther. 2013;29(1):27-32
  8. Acmaz G, Ataş M, Gülhan A, Akar Y, Taskın O, Ozer HO. Evaluation of the macula, retinal nevre fi ber layer, and choroid thickness in woman with polikistik ovary sendrome using spectral-domaıin optical cohorence tomography. Reproad Sci.2014;21(8):1044-49
  9. Akar ME, Taskın O, Yucel I, Taskın O, Ozel A, Akar Y. The effect of the menstrual cycle on optic nevre head analysis in healty women. Can J Ophthalmol. 2005;40(2):175-82
  10. Demir M, Guven D, Koc A, Ozdemir S, Can E. Retinal nevre fi ber layer thickness in women wiyh policystic ovary syndrome. J Ophtalmo.l 2013;2013:752186 11. Magness RR & Rosenfeld CR. Local and systemic östradiol-17 beta. Effects on uterine and systemic vasodilatation. Am JPhysiol 1989;256: 536-542 12. Sarrel PM: Ovarian hormones and the circulation. Maturitas1990; 590(3): 287-298.