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Journals / Retina-Vitreus / 2020 / Cilt: 29 - Sayı: 1

The Relationship Between Disorganitazion of The Retinal Inner Layers and Anti-VEGF Response in Branch Retinal Vein Occlusion

CEMAL ÖZSAYGILI
Necati DURU
Pages
53–58
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Therefore, the presence of DRIL at baseline and extent of DRIL following treatment might serve as a potential SD-OCT biomarker for patients with ME secondary to treatment-naive-BRVO.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: To determine whether the disorganization of retinal inner layers (DRIL) on spectral-domain (SD) OCT is associated with visual outcomes in eyes with treatment-naive branch retinal vein occlusion (BRVO).
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Key Findings & Data:Materials and Methods: Thirty-two eyes of 32 treatment-naive patients with macular edema (ME) due to BRVO receiving three initial consecutive monthly intravitreal ranibizumab were enrolled in this study.
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Conclusion & Impact:Therefore, the presence of DRIL at baseline and extent of DRIL following treatment might serve as a potential SD-OCT biomarker for patients with ME secondary to treatment-naive-BRVO.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Purpose: To determine whether the disorganization of retinal inner layers (DRIL) on spectral-domain (SD) OCT is associated with visual outcomes in eyes with treatment-naive branch retinal vein occlusion (BRVO). Materials and Methods: Thirty-two eyes of 32 treatment-naive patients with macular edema (ME) due to BRVO receiving three initial consecutive monthly intravitreal ranibizumab were enrolled in this study. SD-OCT images from baseline, 3rd-month, 6th-month visits were observed and the presence and extent of DRIL was examined in the central 1-mm-wide foveal area. The effi cacy of the ranibizumab treatment, assessed by best-corrected visual acuity (BCVA), was evaluated at baseline, 3-month and 6-month visits. Results: A total of 32 eyes were included and DRIL was present in 14 (43.7%) eyes at baseline and 9 eyes (28.1%) at 6th month (P:0.01). Baseline DRIL was found to be associated with lower baseline BCVA (0.46 LogMAR for without DRIL vs. 0.65 LogMAR for DRIL, P: 0.013) and higher central retinal thickness (405.7 vs. 442.8, P: 0.016). Decrease in DRIL intensity at 3-month follow-up was associated with increased visual acuity (VA) at 6 months (P:0.001) and baseline DRIL extent was a predictive parameter for 6 months improvement in VA (p:0.01). Sixmonth DRIL change was related to 6-month VA improvement (Pearson’s correlation test, r=0.726, P<0.001). Conclusion: In the present study, it was observed that the improvement of BCVA was found to be related to the decrease of the DRIL intensity. Therefore, the presence of DRIL at baseline and extent of DRIL following treatment might serve as a potential SD-OCT biomarker for patients with ME secondary to treatment-naive-BRVO.

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Cite This Article

ÖZSAYGILI, C., DURU, N. (2020). The Relationship Between Disorganitazion of The Retinal Inner Layers and Anti-VEGF Response in Branch Retinal Vein Occlusion. Retina-Vitreus, Cilt: 29 - Sayı: 1, 53–58. https://ajindex.com/articles/304785

References (13)

  1. Rogers S, McIntosh RL, Cheung N, et al. The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology. 2010;117(2):313-319
  2. Jaulim A, Ahmed B, Khanam T, et al. Branch retinal vein occlusion: epidemiology, pathogenesis, risk factors, clinical features, diagnosis, and complications. An update of the literature. Retina. 2013;33(5):901-910
  3. Ota M, Tsujikawa A, Kita M, et al. Integrity of foveal photoreceptor layer in central retinal vein occlusion. Retina. 2008;28(10):1502-1508. doi:10.1097/ IAE.0b013e3181840b3c
  4. Rogers SL, McIntosh RL, Lim L, et al. Natural history of branch retinal vein occlusion: an evidence-based systematic review. Ophthalmology. 2010;117(6):1094-1101
  5. Sun JK, Lin MM, Lammer J, et al. Disorganization of the retinal inner layers as a predictor of visual acuity in eyes with center-involved diabetic macular edema. JAMA Ophthalmol. 2014;132(11):1309-1316. doi:10.1001/ jamaophthalmol.2014.2350
  6. Radwan SH, Soliman AZ, Tokarev J, et al. Association of Disorganization of Retinal Inner Layers With Vision After Resolution of Center-Involved Diabetic Macular Edema. JAMA Ophthalmol. 2015;133(7):820-825
  7. Yilmaz H, Durukan AH. Disorganization of the retinal inner layers as a prognostic factor in eyes with central retinal artery occlusion. Int J Ophthalmol 2019;12(6):990-995
  8. Sun JK, Radwan SH, Soliman AZ, et al. Neural Retinal Disorganization as a Robust Marker of Visual Acuity in Current and Resolved Diabetic Macular Edema. Diabetes. 2015 Jul;64(7): 2560–70
  9. Moein HR, Novais EA, Rebhun CB, et al. Optical coherence tomography angiography to detect macular capillary ischemia in patients with inner retinal changes after resolved diabetic macular edema. Retina 2017;38:2277-84
  10. C Rasendran, T F Conti, G L Hom,et al. Current understanding of the pathophysiology of disorganization of the retinal inner layers and relationship to visual acuity. American Journal of Ophthalmic Clinical Trials. doi:10.25259/AJOCT-2-2019
  11. Dodo Y, Murakami T, Uji A, et al. Disorganized retinal lamellar structures in nonperfused areas of diabetic retinopathy. Investig Opthalmol Vis Sci 2015;56:2012
  12. Mimouni M, Segev O, Dori D, et al. Disorganization of the retinal inner layers as a predictor of visual acuity in eyes with macular edema secondary to vein occlusion. Am J Ophthalmol. 2017;182(11):160-167. doi:10.1016/j. ajo.2017.08.005
  13. Babiuch A S, Han M, Conti