Comparison of ferritin levels in preeclampsia and normal pregnancies

Objective & Hypothesis:Objective: The aim of this study was to evaluate nonenzymatic endogenous antioxidant (ferritin) levels in patients with preeclampsia and in normotensive healthy pregnant women.

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Key Findings & Data:Methods: In a prospective study design, 83 preeclamptic women and 30 control patients without systemic disease were included in the study at the Yüzüncü Y›l University Medical Faculty, Department of Obstetrics and Gynecology.

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Conclusion & Impact:Conclusions: Our study has shown a significant difference in serum ferritin levels between the preeclamptic and normal pregnant patients.

🔬Design:Research Article

📍Scope:2000 Verileri

⚙️Variables:Preeklampsi · Ferritin · Antioksidanlar

Abstract

Objective: The aim of this study was to evaluate nonenzymatic endogenous antioxidant (ferritin) levels in patients with preeclampsia and in normotensive healthy pregnant women. Methods: In a prospective study design, 83 preeclamptic women and 30 control patients without systemic disease were included in the study at the Yüzüncü Y›l University Medical Faculty, Department of Obstetrics and Gynecology. None of the patients had taken iron supplementation. Hemoglobin, hematocrit, and ferritin levels were measured. Serum ferritin concentration was measured by L2KFE2 kitts (IMMULITE 2000, DPC, Los Angeles/USA). Results: There were no differences in the hemoglobin and hematocrit levels among the two groups. A significant difference was observed in the serum ferritin concentration between study and control groups [80 (12.5-1039) ng/ml vs 11.5 (1-45.6) ng/ml]. Conclusions: Our study has shown a significant difference in serum ferritin levels between the preeclamptic and normal pregnant patients.

Özet

Amaç: Çalışmanın amacı, preeklamptik ve normal gebelerin kanındaki enzimatik olmayan endojen antioksidan düzeyinin (ferritin) incelenmesidir. Yöntem: Yüzüncü Yıl Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Servisinde yatırılarak takip ve tedavisi yapılan 83 preeklampsi olgusu ile sistemik hastalığı olmayan 30 kontrol olgusu çalışmaya dahil edildi. Çalışma grubunu oluşturan hastalardan hiçbiri gebelik süresince düzenli kontrole gelmemiş ve demir desteği almamıştı. Kontrol grubu gebeler de düzenli demir desteği almayan hastalardan seçildi. Çalışmaya dahil edilen olguların hemoglobin, hematokrit ve ferritin düzeyleri ölçüldü. Serum ferritin düzeyi Bio DPC firmasına (Los Angeles/USA) ait kitlerle (L2KFE2) IMMULITE 2000 cihazında Immunometric metoduyla değerlendirildi. Bulgular: Olguların hemoglobin ve hematokrit değerleri incelendiğinde her iki grubun benzer olduğu görüldü. Olguların ferritin değerlerine bakıldığında kontrol grubunda 11.5 (1-45.6) ng/ml, hasta grubunda 80 (12.5-1039) ng/ml idi ve aradaki fark istatistiksel olarak anlamlıydı (p=0.001). Sonuç: Çalışmamız, preeklamptik gebelerde serum ferritin düzeyinin normal gebelere oranla anlamlı derecede yüksek olduğunu göstermiştir.

Keywords

Preeklampsi Ferritin Antioksidanlar Gebelik Pre-Eclampsia Antioxidants Pregnancy

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Cite This Article

ZETEROĞLU, Ş., ÜSTÜN, Y., ÜSTÜN, E. Y., GÜVERCİNCİ, M., ŞAHİN, G., KAMACI, M. (2004). Comparison of ferritin levels in preeclampsia and normal pregnancies. Perinatoloji Dergisi, Cilt: 12 - Sayı: 2, 70–73. https://ajindex.com/articles/300432

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