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Journals / Perinatoloji Dergisi / 2004 / Cilt: 12 - Sayı: 4

İntracardiac hyperechogenic focus: Is it a marker for to the on the trisomy 21 in the Turkish population?

İntrakardiak hiperekojenik odağın Türk populasyonunda Down sendromu belirteci olarak kullanımı

H. Fehmi YAZICIOĞLU
O. Nuri ÖZYURT
Özlem DÜLGER
Atilla ÇANKAYA
Mehmet AYGÜN
Reyhan DEMİRBAŞ
Pages
163–167
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Overall trisomy 21 was found in 9 of 5877(0.15%) cases.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study is to determine the frequency of intracardiac echogenic foci in normal and trisomic cases, and analyse its usefulness as a marker of trisomy 21 in our population.
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Key Findings & Data:Methods: All cases who applied during 21.07.2000-25.05.2004 to the prenatal diagnosis department of the Süleymaniye Maternity Hospital for a detailed ultrasonographic examination underwent routine fetal cardiac screening involving four chamber and great vessel views.
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Conclusion & Impact:Overall trisomy 21 was found in 9 of 5877(0.15%) cases.
🔬Design:Research Article
📍Scope:2000 Verileri
⚙️Variables:Doğum öncesi tanı · Tanı teknik ve işlemleri · Down sendromu

Abstract

Objective: The aim of this study is to determine the frequency of intracardiac echogenic foci in normal and trisomic cases, and analyse its usefulness as a marker of trisomy 21 in our population. Methods: All cases who applied during 21.07.2000-25.05.2004 to the prenatal diagnosis department of the Süleymaniye Maternity Hospital for a detailed ultrasonographic examination underwent routine fetal cardiac screening involving four chamber and great vessel views. Location and number of intracardiac echogenic foci and the presence of cardiac and other sonographic anomalies were detected. The frequency of trisomy 21 in cases with and without hyperechogenic foci was determined by analysis of antenatal and neonatal recordings. c2, pvalues and Odds Ratios were calculated using the program SPSS Ver.10.0.1 (SPSS Inc.Chicago, Illinoi) Results: Intracardiac hyperechogenic foci (HEF) were found in 196 (3.33 %) of 5877 cases. HEF were located left, right and bilateral in 88 (44.89 %), 86 (43.87 %) and 22 (11.22 %) cases respectively. 179 cases had isolated HEF, whereas in 17 HEF was accompanied by other soft markers for trisomy 21. Overall trisomy 21 was found in 9 of 5877(0.15%) cases. Trisomy 21 frequency was 0.12 % (7/5681), 1.02 % (2/196) and 11.76 % (2/17) in cases without HEF, with HEF but without considering the presence of additional soft markers and HEF+ any soft marker for trisomy 21 respectively. None of the cases with isolated HEF had trisomy 21. OR values and 5-95 percent confidence intervals for trisomy 21 in isolated HEF, HEF without considering the presence of additional soft markers and HEF + soft marker groups were 2,11(0,12- 37,16), 8,35(1,72-40,50) ve 111,49 (21,37-581,40) respectively. Conclusion: Isolated HEF carries no significantly increased risk for trisomy 21 in a low risk Turkish population. But a detailed ultrasonographic examination is recommended to exclude the presence of other subtle signs (soft markers) of trisomy 21.

Özet

Amaç: İntrakardiak hiperekojenik odağın normal ve trisomik olgularda sıklığını saptayarak, kendi populasyonumuzda trisomi 21 belirteci olarak kullanabilirliğini irdelemek. Yöntem: Prenatal Tanı Ünitemize 21.07.2000-25.05.2004 tarihleri arasında ayrıntılı ultrason için başvuran tüm gebelere 4 kadran ve büyük damar çıkışlarını da içeren fetal kalp taraması yapılarak intrakardiak hiperekojenik odakların yeri, sayısı, kardiak ve diğer ultrasonografik anomaliler ile birlikteliği tesbit edildi. Hiperekojenik odak içeren ve içermeyen gruplardaki trisomi sıklığı antenatal ve neonatal kayıtlardan belirlendi. İstatistik analiz için SPSS Ver 10.0.1 (SPSS Inc. Chicago, Illinois) programı kullanılarak c2, p-değeri ve OR (Odds ratio) değerleri hesaplandı. Bulgular: Tarama yapılan toplam 5877 olgudan 196(%3.33) tanesinde intrakardiak hiperekojenik odak (HO) saptandı. HO 88(%44.89) olguda solda, 86(%43.87) olguda sağda ve 22(%11.22) olguda bilateraldi. HO 17 olguda diğer trisomi belirteçleri ile birlikte, geri kalan 179 olguda izole idi. Taranan 5877 olgudan 9 tanesinde trisomi 21 saptandı (%15). HO saptanmayan, HO saptanan ancak ek belirteç olup olmadığı bilgisi gözardı edilen ve HO ile birlikte trisomi 21 için ek belirteç içeren olgularda trisomi 21 sıklığı sırası ile % 0.12 (7/5681), % 1.02 (2/196) ve %11.76 (2/17) olarak saptandı. İzole HO olgularının ise hiçbirinde trisomi 21 saptanmadı. Odds ratio değerleri ve 5-95 % güvenilirlik aralıkları izole HO, HO ve ek belirteçle birlikte HO için sırasıyla 2,11(0,12- 37,16), 8,35(1,72-40,50) ve 111,49 (21,37-581,40) bulundu. Sonuç: İzole intrakardiak hiperekojenik odak trisomi 21 için anlamlı risk artışını ifade etmez, ancak ek belirteçlerle birlikte risk anlamlı biçimde arttığından ayrıntılı ultrasonografik muayene için bir endikasyon oluşturur.

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Cite This Article

YAZICIOĞLU, H. F., ÖZYURT, O. N., DÜLGER, Ö., ÇANKAYA, A., AYGÜN, M., DEMİRBAŞ, R. (2004). İntracardiac hyperechogenic focus: Is it a marker for to the on the trisomy 21 in the Turkish population?. Perinatoloji Dergisi, Cilt: 12 - Sayı: 4, 163–167. https://ajindex.com/articles/300403

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References (1)

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