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Journals / Perinatoloji Dergisi / 2005 / Cilt: 13 - Sayı: 3

Maternal serum concentrations of the metabolites of nitric oxide preeclampsia

Preeklampsili gebelerde maternal serum nitrik oksit metabolitlerinin seviyeleri

Levent TÜTÜNCÜ
Emine ÖZDEMİR
Ercüment MÜNGEN
Ali Rüştü ERGÜR
Yusuf Z. YERGÖK
Pages
142–147
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This may be a compensatory mechanism to increase the blood flow to uteroplacental unit in preeclampsia.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The purpose of this study was to determine the serum levels of nitric oxide (NO) metabolites in pregnant women with preeclampsia and to find out any relation between the pathogenesis of preeclampsia and NO levels.
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Key Findings & Data:Methods: In this prospective, case-control study, venous blood samples were collected from pregnant women with preeclampsia (n=30) and age-matched healthy pregnant women (n=30).
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Conclusion & Impact:This may be a compensatory mechanism to increase the blood flow to uteroplacental unit in preeclampsia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Nitratlar · Nitrik oksit · Nitritler

Abstract

Objective: The purpose of this study was to determine the serum levels of nitric oxide (NO) metabolites in pregnant women with preeclampsia and to find out any relation between the pathogenesis of preeclampsia and NO levels. Methods: In this prospective, case-control study, venous blood samples were collected from pregnant women with preeclampsia (n=30) and age-matched healthy pregnant women (n=30). The serum fractions of these samples were assayed for total nitrite/nitrate levels. The outcomes of the pregnancies were evaluated and groups were compared to each other for the clinical characteristics and NO metabolites. Student's paired t-test and X2test were used for the statistical analysis. P value less than 0.05 was considered statistically significant. Results: The mean total serum levels of nitrite/nitrate in pregnant women with preeclampsia and healthy pregnant women were 59.0 ± 15.55 $\mu$mol/L and 41.0 ± 10.37 $\mu$mol/L respectively. There were significantly higher total nitrite/nitrate levels in the maternal serum of preeclamptic women (p<0.05). Also, significantly higher nitrite/nitrate levels were found in severe preeclamptic women compared with those of mild preeclamptic and healthy pregnant women (p<0.05). Conclusion: Maternal serum levels of NO metabolites were higher in pregnant women with preeclampsia and it was directly related with the severity of the disease. This may be a compensatory mechanism to increase the blood flow to uteroplacental unit in preeclampsia.

Özet

Amaç: Bu çalışmanın amacı, preeklamptik gebelerdeki nitrik oksit (NO) metabolitlerinin serum seviyelerini tespit etmek ve NO seviyesi ile preeklampsi arasında bir ilişki olup olmadığını ortaya çıkartmaktır. Yöntem: Bu prospektif, vaka kontrollü çalışmada preeklampsi tanısı konulmuş gebe kadınlardan (n=30) ve benzer yaş grubundaki sağlıklı gebelerden venöz kan örnekleri alındı. Alınan kan örneklerinin serum fraksiyonlarında toplam nitrit/nitrat konsantrasyonu hesaplandı. Daha sonra her iki grupdaki gebeliklerin sonuçları araştırıldı ve iki grup klinik özellikleri ile NO metabolitleri açısından birbirleri ile karşılaştırıldı, istatistiksel değerlendirme için eşli t-test ve %2 test kullanıldı. 0.05'den küçük p değeri istatistiksel olarak anlamlı kabul edildi. Bulgular: Preeklamptik ve sağlıklı gebelerde ortalama toplam nitrit/nitrat seviyeleri sırasıyla 59.0 ± 15.55 $\mu$mol/L ve 41.0 ± 10.37 $\mu$mol/L olarak bulundu. Preeklamptik gebelerin maternal serumlarında toplam nitrit/nitrat seviyeleri anlamlı derecede daha yüksekti (p<0.05). Ayrıca şiddetli preeklampsi tanısı alan gebelerdeki nitrit/nitrat seviyeleri, hafif preeklamptik ve sağlıklı gebelerle karşılaştırıldığında, anlamlı derecede yüksek saptandı (p<0.05). Sonuç: Bu çalışmada NO metabolitlerinin maternal serum seviyeleri preeklamptik gebelerde daha yüksek saptandı ve bu yükseklik preeklampsinin şiddeti ile doğru orantılı olarak bulundu. Bu artış, preeklampside uteroplasental kan akımını artırmaya yönelik kompensatuar bir mekanizma olabilir.

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Cite This Article

TÜTÜNCÜ, L., ÖZDEMİR, E., MÜNGEN, E., ERGÜR, A. R., YERGÖK, Y. Z. (2005). Maternal serum concentrations of the metabolites of nitric oxide preeclampsia. Perinatoloji Dergisi, Cilt: 13 - Sayı: 3, 142–147. https://ajindex.com/articles/300366

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