The assessment of early and late gestational termination cases

Conclusion: When the late gestational terminations performed in our clinic are compared to the early gestational terminations, we believe that conducting ultrasonographic anomaly screening to all pregnant women including echocardiography even at a less rate, and also making screening programs in the early gestational periods such as aneuploidy screening easily accessible for all pregnant women may help to maintain maternal health by decreasing the rates of the cases with late gestational termination.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: We aimed to investigate the characteristics of early and late gestational termination cases by evaluating the cases underwent gestational termination in our clinic.

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Key Findings & Data:Methods: All pregnant women who had singleton pregnancy and underwent gestational termination due to fetal indications between January 2017 and December 2019 were included in the study.

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Conclusion & Impact:Conclusion: When the late gestational terminations performed in our clinic are compared to the early gestational terminations, we believe that conducting ultrasonographic anomaly screening to all pregnant women including echocardiography even at a less rate, and also making screening programs in the early gestational periods such as aneuploidy screening easily accessible for all pregnant women may help to maintain maternal health by decreasing the rates of the cases with late gestational termination.

🔬Design:Research Article

📍Scope:2017 Verileri

⚙️Variables:Domain Parameters

Abstract

Objective: We aimed to investigate the characteristics of early and late gestational termination cases by evaluating the cases underwent gestational termination in our clinic. Methods: All pregnant women who had singleton pregnancy and underwent gestational termination due to fetal indications between January 2017 and December 2019 were included in the study. Results: A total of 341 cases, of which 263 were with early gestational termination (Group 1) and 73 were with late gestational termination (Group 2) were included in the study. No difference was observed between the demographic characteristics of the groups. The ultrasonographic structural anomaly was observed in 273 (80.1%) of 341 cases and no structural anomaly was observed in 68 (19.9%) cases. Of the cases with structural anomaly, 200 (73%) had isolated system anomaly and 73 (26.7%) had multiple system anomaly. Karyotype analysis was performed in 68% of the cases, and chromosomal anomaly was found in 52.6% of them. Among the cases with normal karyotype analysis results, 22 cases had single gene disorder, of which mostly had thalassemia. While the incidence of structural anomaly was significantly high in the late termination cases (91% vs. 76.8%), the incidence of isolated cardiovascular anomaly was significantly high in the late termination cases similarly (37.5% vs. 13.8%). The autopsy was performed on 16.7% of the cases after termination and the findings were consistent with the prenatal ultrasonographic results in 86% of the cases, and additional findings were found in 22.4% of the cases in the autopsy. Conclusion: When the late gestational terminations performed in our clinic are compared to the early gestational terminations, we believe that conducting ultrasonographic anomaly screening to all pregnant women including echocardiography even at a less rate, and also making screening programs in the early gestational periods such as aneuploidy screening easily accessible for all pregnant women may help to maintain maternal health by decreasing the rates of the cases with late gestational termination.

Özet

Amaç Kliniğimizdeki gebelik terminasyonu uygulanan olguların incelenerek erken ve geç gebelik terminasyonu olgularının özelliklerinin araştırılması amaçlandı. Yöntem Ocak 2017 ile Aralık 2019 arasında tekil gebeliği olan ve fetal endikasyonlara bağlı gebelik terminasyonu uygulanan tüm gebeler çalışmaya dahil edildi. Bulgular Çalışmaya 263’ü erken gebelik terminasyonu (Grup 1) ve 78’i geç gebelik terminasyonu (Grup 2) olmak üzere 341 olgu dahil edildi. Grupların demografik özellikleri arasında fark izlenmedi. 341 olgunun 273’ünde (%80.1) ultrasonografide yapısal anomali saptanırken, 68 (%19.9) olguda yapısal anomali izlenmedi. Yapısal anomali izlenen olguların 200’ünde (%73) izole sistem anomalisi saptanırken, 73 olguda (%26.7) çoklu sistem anomalisi bulundu. Olguların %68’ine karyotip analizi uygulandı ve bunların %52.6’sında kromozom anomalisi saptandı. Karyotip analizi sonucu normal olan olgular arasında çoğunluğu talasemi olmak üzere 22 olguda tek gen hastalığı saptandı. Geç terminasyon olgularında yapısal anomali (%91’e karşı %76.8) sıklığı anlamlı olarak yüksek saptanırken benzer şekilde izole kardiyovasküler anomali (%37.5’e karşı %13.8) sıklığı da geç terminasyon olgularında anlamlı yüksekti. Terminasyon sonrası olguların %16.7’sine otopsi uygulandı ve bunların %86’sında prenatal ultrasonografik bulgularla uyum izlenirken %22.4 olguda otopside ek bulgu saptandı. Sonuç Kliniğimizde uygulanan geç gebelik terminasyonları erken gebelik terminasyonları ile kıyaslandığında daha az olmakla birlikte ekokardiyografinin dahil edildiği ultrasonografik anomali taramasının tüm gebelere uygulanması ve aynı zamanda anöploidi taraması gibi erken gebelik haftalarındaki tarama programlarının tüm gebeler için kolay ulaşılabilir kılınması geç gebelik terminasyonu olgularının daha da azalmasını sağlayarak maternal sağlığın korunmasına katkı sağlayabilir.

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Cite This Article

KAYA, S., VAİZOĞLU, F., UZUNER, S. Y., TORU, H. S., ŞİMŞEK, M., KUMRU, S. (2020). The assessment of early and late gestational termination cases. Perinatoloji Dergisi, Cilt: 28 - Sayı: 2, 82–88. https://ajindex.com/articles/300298

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