Diagnostic value of C-reactive protein in unstable angina pectoris

CONCLUSION: We found that serum levels of CRP, one of the predictors of inflamatory process which may contribute to the pathogenesis of myocardial ischemia, showed independent pattern from the severity of the ischemia.

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: It has been suggested that inflammation may have a role in the patogenesis of unstable angina pectoris (UAP).

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Key Findings & Data:MATERIAL AND METHOD: 30 patients with unstable angina pectoris , mean age of 60±8 years (21 men and 9 women ) of Braunwald class IIIB and 25 patients with chronic stable angina (SAP) , mean age of 62±7 years(11 men and 14 women ) were included into the study.

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Conclusion & Impact:CONCLUSION: We found that serum levels of CRP, one of the predictors of inflamatory process which may contribute to the pathogenesis of myocardial ischemia, showed independent pattern from the severity of the ischemia.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Enflamasyon · Tanı · Anjina

Abstract

AIM: It has been suggested that inflammation may have a role in the patogenesis of unstable angina pectoris (UAP). We studied the level of the circulating acute phase reactant, C-reactive protein (CRP), in UAP patients as a diagnostic marker. MATERIAL AND METHOD: 30 patients with unstable angina pectoris , mean age of 60±8 years (21 men and 9 women ) of Braunwald class IIIB and 25 patients with chronic stable angina (SAP) , mean age of 62±7 years(11 men and 14 women ) were included into the study. All patients had their blood taken within the first 24 hours of the beginning of their ischemic chest pain (early period ), for the measurement of CRP levels. RESULTS: CRP levels of UAP patients were significantly higher than the chronic SAP patients, (p<0.001), when males were compared with females, CRP levels were significantly higher in female UAP patients than in male UAP patients (p<0.05). CONCLUSION: We found that serum levels of CRP, one of the predictors of inflamatory process which may contribute to the pathogenesis of myocardial ischemia, showed independent pattern from the severity of the ischemia.

Özet

AMAÇ: Kararsız angina pektorisin (UAP) patogenezinde inflamasyonun rolü olduğu bilinmektedir. Bu çalışmada inflamasyonun duyarlı bir göstergesi olan C-reaktif protein (CRP)'in UAP'li hastalarda tanısal değeri araştırılmıştır. GEREÇ VE YÖNTEM: Çalışmaya Braunwald klas IIIB UAP'li, yaş ortalaması 60±8 yıl olan 30 hasta (21 erkek, 9 kadın) ve kronik kararlı angina pektoris (SAP)'li , yaş ortalaması 62±7 yıl olan 25 hasta (11erkek, 14 kadın) alındı. Tüm vakalardan iskemik karakterli son göğüs ağrısını takip eden 24 saat içerisinde (erken dönem) serum CRP düzeyi tayini için kan alındı. BULGULAR: UAP vaka grubunda, kronik SAP vaka grubuna göre CRP düzeyi anlamlı yüksek bulundu, (p<0.001). Kadın ve erkek hastalar aralarında karşılaştırıldıklarında UAP'li kadınlarda CRP düzeyi erkek hastalara göre anlamlı yüksek saptandı,(p<0.05). SONUÇ: Miyokart iskemisinin patogenezinde rol alan inflamasyonun akut faz göstergelerinden biri olan CRP'in, hastalarda, iskeminin şiddetinden bağımsız bir marker olarak hareket ettiği saptandı.

Keywords

Enflamasyon Tanı Anjina kararsız C-reaktif protein Miyokard iskemisi Inflammation Diagnosis Angina Unstable C-Reactive Protein Myocardial Ischemia

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Cite This Article

KILIÇ, A., SOYSAL, D., HARMANDA, A., YILDIZ, Ç., SUSAM, İ., ER, H. (2002). Diagnostic value of C-reactive protein in unstable angina pectoris. MN Kardiyoloji, Cilt: 9 - Sayı: 3, 185–188. https://ajindex.com/articles/299126

References (12)

Rutherford J. Braunwald E, Chronic İschemic Heart Disease. A Textbook of cardiovascular medicine. 4th. Ed Philadelphia: W;B. Saunders Comp. 1992:1292-1364. Braunwald E. Unstable angina a classification. Circulation 1989; 80:410-4.
Kırımlı Ö, Güneri S, Ündar B, Budak Ö, Aslan Ö, Akdeniz B ve ark. Unstable angina pektoriste C-reaktif protein, interleukin-6 ve aktive T lenfosit düzeyleri ve iskemi ile ilişkisi. Türk Kardiyoloji Dern Arş. 2001;29:476-80.
Van der Wal AC, Becker A, Van der Loos C, Das PK. Site of intimal rupture or erosion of trorrlbosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation, 1994; 89:36-44.
Moreno PR, Falk E, Palacios IF, Newell JB, Fuster V, Fallon JT et al. Macrofage infiltration in acute coronary syndromes: Implications for plaque rupture. Circulation, 1994; 90:775-8.
Liuzzo G. Biasucci LM, Gallimore JR. The Prognostic value of C- reactive protein and serum amyloid A protein in severe unstable angina. N Engl J Med 1994; 331:417-24.
Neumann FJ, Ott I, Gawaz M et al. Cardiac release of cytokines and inflammatory response in acute myocardial infarction. Circulation 1995;92:748-55.
Bardsley WT, Mankin HT, Miller TD. Electrocardiography. Exercise testing. In: Giuliani ER, Gersh BJ, Me Goon MD, Hayes DL, Schaff HV, editors. Mayo Clinic Practice of Cardiology. Missouri: Mosby, 1996: 114-41. From Joint National Committee: The Fifth Report of the Joint National Commitee on Detection, Evaluation and Treatment of High Blood Pressure (JNC V). Arch Intern Med. 1993; 153:154-83.
Eikelboom JW, Hankey GJ,. Associations of homocysteine, C- reactive protein and cardiovascular disease in patients with renal disease. Curr Opin Nephrol Hypertens 2001; 10:377-83.
Koukkunen H, Penttila K, Kemppainen A, Halinen M, Penttilla I, Rantanen T, C-reactive protein, fibrinogen, interleukin-6 and tumour necrosis factor-alpha in the prognostic classification of unstable angina pectoris. Ann Med 2001; 33:37-47.
Kennon S, Price CP, Mills PG, Ranjadayalan K, Cooper J, Clarke H et al. The effect of aspirin on C-reactive protein as a marker of risk in unstable angina. J Am Coll Cardiol 2001; 37:1266-70.
Toss H, Gnarpe J, Gnarpe H, Siegbahn A, Lindahl B, Wallentin L, increased fibrinogen levels are associated with persistent chlamydia pneumoniae infection in unstable coronary artery disease. Eur Heart J.:1998; 19:570-7.
Mulvihill NT, Foley JB, Murphy RT, Curtin R, Crean PA, Walsh M.