Journals / Mikrobiyoloji Bülteni / 2009 / Cilt: 43 - Sayı: 2

Prevalence of house dust mite allergy in cases with atopic disease symptoms in Kocaeli province, Turkey

Kocaeli bölgesinde atopik hastalık semptomları olan olgularda ev tozu akarı alerji prevalansı

Pages
309–312
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

In conclusion, it was determined that the rate of the sensitization against house dust mite was high in Kocaeli, Turkey and it exhibited an increasing tendency with age.

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of this study was to investigate the prevalence of house dust mite sensitization and to detect the IgE and eosinophilic cationic protein (ECP) levels in the positive cases living in Kocaeli province (located in Northwest region of Turkey).
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Key Findings & Data:The results of mixed house dust mite skin tests of 1279 patients (620 male, 659 female) of which 670 were children (3-14 years), 68 were adolescents (15-19 years) and 541 were adults (20-86 years) who were admitted to Kocaeli University Medical Faculty Hospital during the period of January 2003-January 2005, with symptoms of atopic disease such as upper/lower respiratory tract symptoms, asthma and/or rhinitis and/or eczema were evaluated retrospectively.
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Conclusion & Impact:In conclusion, it was determined that the rate of the sensitization against house dust mite was high in Kocaeli, Turkey and it exhibited an increasing tendency with age.
🔬Design:Research Article
📍Scope:2003 Verileri
⚙️Variables:Deri testleri · İmmunoenzim teknikleri · İmmünoglobulin E

Abstract

The aim of this study was to investigate the prevalence of house dust mite sensitization and to detect the IgE and eosinophilic cationic protein (ECP) levels in the positive cases living in Kocaeli province (located in Northwest region of Turkey). The results of mixed house dust mite skin tests of 1279 patients (620 male, 659 female) of which 670 were children (3-14 years), 68 were adolescents (15-19 years) and 541 were adults (20-86 years) who were admitted to Kocaeli University Medical Faculty Hospital during the period of January 2003-January 2005, with symptoms of atopic disease such as upper/lower respiratory tract symptoms, asthma and/or rhinitis and/or eczema were evaluated retrospectively. Serum IgE and ECP levels of all cases were determined by enzyme immunoassay method (UniCAP 100 System, Pharmacia, Uppsala, Sweden). The allergy test performed by using mixed house dust mite panel (Dermatophagoides pteronyssinus, Dermatophagoides farinae) was found positive in 328 (25%) cases. Among those 154 (46.9%) were sensitive to D.pteronyssinus, 151 (46%) were sensitive to D.farinae, and 23 (7%) were sensitized to both mites. The mean IgE (259 ± 25.5 kU/ml) and ECP levels (35.7 ± 17.9 kU/ml) of house dust mite sensitized cases were found significantly higher than the non-sensitized subjects (IgE; 144 ± 18.9 kU/ml, ECP; 33.1 ± 18.3 kU/ml) (p< 0.001). The prevalence rates of house dust mite allergy in our region were determined as 17% (114/670), 19.1% (13/68), and 37.1% (201/541) in pediatric, adolescent and adult populations, respectively. There was no predilection for allergy prevalence in terms of sex (p= 0.7). However, the prevalence increases during autumn-winter seasons (p= 0.01 and p= 0.007, respectively). In conclusion, it was determined that the rate of the sensitization against house dust mite was high in Kocaeli, Turkey and it exhibited an increasing tendency with age.

Özet

Bu çalışmada Kocaeli bölgesinde ev tozu akarı alerji prevalansının saptanması ve pozitif olgularda IgE ile eozinofilik katyonik protein (EKP) yanıtlarının araştırılması amaçlanmıştır. Çalışmada Kocaeli Üniversitesi Tıp Fakültesi Hastanesine Ocak 2003-0cak 2005 tarihlerinde üst ve/veya alt solunum yolu semptomları, astım ve/veya rinit ve/veya egzema gibi alerjik hastalık semptomları ile başvuran 670'i çocuk (3-14 yaş), 68'i adölesan (15-19 yaş) ve 541'i erişkin (20-86 yaş) olmak üzere toplam 1279 olgunun (620 erkek, 659 kadın) karma (miksed) ev tozu alerji deri testi sonuçları retrospektif olarak değerlendirilmiştir. Tüm olguların serum örneklerinde IgE ve EKP düzeyleri enzim immunoassay (UniCAP 100 System, Pharmacia, İsveç) yöntemiyle ölçülmüştür. Olguların 328 (%25.6)'inde karma ev tozu akar paneli (Dermatop- hagoides pteronyssinus ve Dermatophagoides farinae) ile alerji testi pozitif bulunmuş; bunların 154 (%46.9)'ünde D.pteronyssinus, 151 (%46)'inde D.farinae, 23 (%7)'ünde ise her ikisine karşı da duyarlılık saptanmıştır. Ev tozu aşırı duyarlılığı olan olguların ortalama IgE (259 ± 25.5 kU/ml) ve ortalama EKP düzeyleri (35.7 ± 17.9 kU/ml), aşırı duyarlılığı olmayan olgulardan (IgE; 144 ±18.9 kU/ml, EKP; 33.1 ± 18.3 kU/ml) anlamlı olarak daha yüksek bulunmuştur (p< 0.001). Ev tozu akarı alerji oranlan çocuk, adölesan ve erişkin gruplarda sırasıyla; %17 (114/670), %19.1 (13/68) ve %37.1 (201/541) olarak belirlenmiştir. Alerji prevalansının belirli bir cinsiyet dağılımı göstermediği (p= 0.7), ancak kış-sonbahar mevsimlerinde daha yüksek oranlara ulaştığı (sırasıyla; p= 0.007 ve p= 0.01) izlenmiştir. Sonuç olarak bölgemizde ev tozuna karşı aşırı duyarlılık oranının yüksek olduğu ve yaşla birlikte prevalansın arttığı gözlenmiştir.

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Cite This Article

TAMER, Z. G. S., ÇALIŞKAN, Ş. (2009). Prevalence of house dust mite allergy in cases with atopic disease symptoms in Kocaeli province, Turkey. Mikrobiyoloji Bülteni, Cilt: 43 - Sayı: 2, 309–312. https://ajindex.com/articles/298844

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