Journals / MN Kardiyoloji / 1996 / Cilt: 3 - Sayı: 3

Assesment of myocardial perfusion scintigraphy with technetium-99 m tetrofosmin in coronary artery disease

Teknesyum-99 m tetrofosmin miyokard perfüzyon sintigrafisinin koroner arter hastalığı tanısındaki değeri

Pages
196–198
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In comparison with coronary angiography (n=15), overall sensitivity, specificity, positive and negative predictivity values for detecting coronary artery stenosis (>75%) were 81.8%, 75%, 90% and 60% respectively.

📌 3 Key Takeaways

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Objective & Hypothesis:A novel drug called technetium-99m (Tc-99m) tetrofosmin has been developed to replace thallium-201 in myocardial;perfusion imaging.
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Key Findings & Data:Twenty-eight patients were given Tc-99m tetrofosmin.
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Conclusion & Impact:In comparison with coronary angiography (n=15), overall sensitivity, specificity, positive and negative predictivity values for detecting coronary artery stenosis (>75%) were 81.8%, 75%, 90% and 60% respectively.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

A novel drug called technetium-99m (Tc-99m) tetrofosmin has been developed to replace thallium-201 in myocardial;perfusion imaging. Twenty-eight patients were given Tc-99m tetrofosmin. A standard stress-redistribution imaging protocol was used. Planar imaging was performed 15 minutes after an injection ofTc-99m tetrofosmin (5-8 mCi) at peak graded exercise. Reinjection (15-24 mCi) was performed at rest, 4 hours after the stress injection and imaging was repeated minutes after reenjection . Fifteen patients underwent coronary angiography. Eleven patients had significant coronary artery disease with >75% narrowing, 4 had no arteries with >75% narrowing. In comparison with coronary angiography (n=15), overall sensitivity, specificity, positive and negative predictivity values for detecting coronary artery stenosis (>75%) were 81.8%, 75%, 90% and 60% respectively. In this study it was shown that Tc-99m tetrofosmin is useful as a myocardial perfusion imaging agent.

Özet

Teknesyüm-99m (Tc-99 m) tetrofosmin miyokard perfüzyonunu değerlendirmede talyum-201 'in yerine geliştirilen ye ajanlardan biridir. Çalışmada 28 koroner arter hastasına tek gün stress-redistribüsyon protokolü uygulanarak Tc-9£ tetrofosmin'in miyokard perfüzyon sintigrafisi (MPS)'ndeki değeri araştırıldı. Hastalara pik egzersizde Tc-99m tetrofı min (4-8mCi) intravenöz verildi ve 15 dakika sonra planar görüntüleri, alındı. Egzersizden 4 saat sonra ikinci enjeksiy uygulandı (15-24) ve enjeksiyondan 15 dakika sonra istirahat görüntüleri kaydedildi. 15 hastaya koroner anjiyogr yapıldı. 4 hastanın koroner arterleri normal, 11 hastanın koroner arterlerinde >.%75 darlık tespit edildi. Koroner arteı rinde >%75 darlık olanlarla karşılaştırıldığında Tc-99m tetrofosmin'in MPS'ndeki özgüllüğü %81.8, duyarlılığı %75, pc ttf tahmin edici değeri %90, negatif tahmin edici değeri %60 olarak bulundu. Sonuç olarak, MPS'ni değerlendirmede Tc-99m tetrofosmin'in faydalı bir ajan olduğu kanısına varıldı.

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Cite This Article

TELATAR, M., KULAN, K., KULAN, C., TUNCER, C., KONUKSEVEN, A. (1996). Assesment of myocardial perfusion scintigraphy with technetium-99 m tetrofosmin in coronary artery disease. MN Kardiyoloji, Cilt: 3 - Sayı: 3, 196–198. https://ajindex.com/articles/298232