Chlamydia pneumoniae antibodies and their relationship with restenosis in coronary heart disease patients

Prospective and cohort studies are needed to explain the role of C. pneumoniae IgG antibodies in the pathogenesis of coronary atherosclerosis and restenosis.

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: The aim of this study was to investigate the presence and clinical importance of Chlamydia Pneumoniae (C.

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Key Findings & Data:METHODS: The study population consisted of 32 CHD patients (7 -women, 25 men, mean age: 55.7 +10 1 years) who had PTCA (13 of them, 40.6 %) and CS (19 patients, 59.4 %) and 25 healthy subjects (5 women, 20 men, mean age: 51.6 + 8.3 years) as the control group.

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Conclusion & Impact:Prospective and cohort studies are needed to explain the role of C. pneumoniae IgG antibodies in the pathogenesis of coronary atherosclerosis and restenosis.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Chlamydia enfeksiyonları · Chlamydia pneumoniae · Koroner anjiyografi

Abstract

AIM: The aim of this study was to investigate the presence and clinical importance of Chlamydia Pneumoniae (C. Pneumoniae) antibodies in coronary heart disease (CHD) patients who had undergone percutaneous translüminal coronary angioplasty (PTCA) and coronary stenting (CS). METHODS: The study population consisted of 32 CHD patients (7 -women, 25 men, mean age: 55.7 +10 1 years) who had PTCA (13 of them, 40.6 %) and CS (19 patients, 59.4 %) and 25 healthy subjects (5 women, 20 men, mean age: 51.6 + 8.3 years) as the control group. Sera just obtained before PTCA and CS and 3 and 6 months later were stored at -20°C until being tested. Spesific immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies against C. pneumoniae were detected by microimmunofluorescence (MIF) method. Sera with a dilution of 1/128 with which the elementer bodies of C. pneumoniae gave fluorescence were accepted C. pneumoniae IgG positive. Control coronary angiographic investigation was applied 6 months later after PTCA and CS. RESULTS: C. pneumoniae IgM antibodies were negative in all of the three sera of all the patients. C. pneumoniae IgG antibodies were detected in 3 of 25 (12 %) healthy subjects and 17 of 32 (53 %) CHD patients (p=0.013). Control coronary angiographic investigation applied six month later revealed restenosis in 16 of the 32 patients (50 %). Restenosis was detected in 12 of the 17 patients who had C. pneumoniae IgG antibodies (70.6 %) were as in 4 of the 15 patients (26.6 %) who were negative C. pneumoniae IgG antibodies (p=0.013). CONCLUSION: In our study it -was found out that C. pneumoniae IgG antibody positivity was higher in CHD patients than the healthy control group. This supports recent findings describing the C. pneumoniae infection in the pathogenesis of atherosclerosis. Prospective and cohort studies are needed to explain the role of C. pneumoniae IgG antibodies in the pathogenesis of coronary atherosclerosis and restenosis.

Özet

AMAÇ: Bu çalışmanın amacı, perkütan translüminal koroner anjioplasti (PTCA) ve intrakoroner slent girişimi uygulanan koroner kalp hastaları (KKH) 'nda serum Chlamydia pneumoniae (C. pneumoniae) antikor varlığı ile .restenoz arasındaki ilişkiyi araştırmaktır. YÖNTEM: Çalışma materyelini PTCA (13 hasta, % 40.6) ve koroner stent (19 hasta, % 59.4) uygulanan 32 KKH (7 Kadın. 25 erkek: yaş ortalaması 55. 7 ± 10. l yıl) ve kontrol grubu olarak 25 sağlıklı kişi (5 Kadın, 20 erkek: yaş ortalaması 51.6 ±8.3 yıl) oluşturmuştur. Hastalardan girişimden hemen önce ve ortalama 3 ve 6 ay sonra olmak üzere üç kez alınan kan örnekleri santrifüje edildikten sonra -20°C de saklanmıştır. Tüm serum örneklerinde C. pneumoniae'ye karşı IgG ve IgM antikorlarının varlığı mikroimmünofluoresan yöntemi ile araştırılmış ve 1/128 sulandıranda C. pneumoniae elementer cisimciklerinde fluoresan saptananlar pozitif olarak kabul edilmiştir. Hastalara PTCA ve koroner stent girişiminden ortalama 6 ay sonra kontrol koroner anjiyografik inceleme yapılmıştır. BULGULAR: Kontrol grubundaki sağlıklı 25 kişinin 3 'ünde (% 12) C. pneumoniae IgG antikorları pozitif bulunurken 32 KKH 'nın 17'sinde (% 53) C. pneumoniae IgG antikorları pozitif olarak tesbit edilmiştir (p=0.013). Hastaların tümünde üç ayrı kan örneğinde de C. pneumoniae IgM antikorları negatif bulunmuştur. Altı ay sonra yapılan kontrol anjiyografisinde 32 hastanın 16'sında (% 50) restenoz gelişmiş olduğu saptanmıştır. Chlamydia pneumoniae IgG antikorları pozitif bulunan 17 hastanın 12 'sinde (% 70.6); C. pneumoniae IgG antikorları negatif bulunan 15 hastanın ise 4'ünde (% 26.6) restenoz geliştiği tesbit edilmiştir (p=0.013). SONUÇ: Koroner kalp hastalarında C. pneumoniae IgG antikor pozitifliğinin sağlıklı kişilere göre anlamlı oranda yüksek bulunması sebebi ile çalışmamızın sonuçları C. pneumoniae infeksiyonunun koroner ateroskleroz gelişimim açıklayan son görüşleri desteklemektedir. C. pneumoniae IgG antikorlarının koroner ateroskleroz ve restenoz patogenezindeki rolünün açıklanabilmesi için daha ileri, prospektif ve geniş kapsamlı çalışmaların gerekli olduğu kanısına varılmıştır.

Keywords

Chlamydia enfeksiyonları Chlamydia pneumoniae Koroner anjiyografi Anjiyoplasti transluminal perkutan koroner Stentler Tekrarlama Koroner hastalık Antikorlar bakteriyel Chlamydia Infections Coronary Angiography Angioplasty Transluminal Percutaneous Coronary Stents Recurrence Coronary Disease Antibodies Bacterial

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Cite This Article

OFLAZ, H., YILMAZ, E., NİŞANCI, Y., ÇEKMECELİ, P., ÖZAYDIN, M., AĞAÇFİDAN, A., MERCANOĞLU, F., YILMAZ, G., UMMAN, S., MERİÇ, M., ERZENGİN, F., BÜYÜKÖZTÜRK, K., ÖZSARUHAN, Ö. (2000). Chlamydia pneumoniae antibodies and their relationship with restenosis in coronary heart disease patients. MN Kardiyoloji, Cilt: 7 - Sayı: 1, 4–10. https://ajindex.com/articles/298065

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