Journals / MN Kardiyoloji / 2001 / Cilt: 8 - Sayı: 1

The new exercise QRS score in detecting the severity of coronary artery disease and its relationship with myocardial perfusion

Yeni egzersiz QRS skorunun koroner arter hastalığının ciddiyeti ve miyokard perfüzyonu ile ilişkisi

Pages
23–28
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: The new score has a high sensitivity in diagnosing the severity of CAD and the presence of myocardial ischemia.

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: The aim of the study was to determine the value of the "new QRS score" in diagnosing the presence and severity of coronary artery disease (CAD) and myocardial perfusion abnormalities.
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Key Findings & Data:MATERIAL AND METHODS: Coronary angiography and Tl-201 scintigraphy were performed in 184 (137 men, 47 women) patients with a mean age 56.7±10.4 (range 30-81), who had a positive exercise test or typical angina with negative exercise test.
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Conclusion & Impact:CONCLUSION: The new score has a high sensitivity in diagnosing the severity of CAD and the presence of myocardial ischemia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Koroner hastalık · Perfüzyon · Miyokard hastalıkları

Abstract

AIM: The aim of the study was to determine the value of the "new QRS score" in diagnosing the presence and severity of coronary artery disease (CAD) and myocardial perfusion abnormalities. MATERIAL AND METHODS: Coronary angiography and Tl-201 scintigraphy were performed in 184 (137 men, 47 women) patients with a mean age 56.7±10.4 (range 30-81), who had a positive exercise test or typical angina with negative exercise test. Patients were divided in four groups according to the coronary angiographic findings: single vessel disease (SVD), double vessel disease (DVD), three vessel disease (TVD) and the normal coronary arteries. In each group QRS scores were compared with ST segment depression. The amplitude of the Q, R and S waves were measured from the isoelectric line, before and immediately after exercise, then D values were obtained by substracting preexercise values than postexercise values. By using these D values, the QRS score was calculated: (DR-DQ-DS)AVF +(DQ-DR-DS)V5. RESULTS: Using a cut-off point of ³1.5 as normal, QRS score had a better sensitivity than ST segment depression in diagnosing CAD (respectively 82%, 71% p<0,01), but specificity (75%, 73%) and positive predictive value (89%, 85%) was not statistically different from ST segment depression. In single-vessel disease significant difference was found in sensitivity between the QRS score and ST segment depression. We found that the number of obstructed coronary artery increase as the QRS score decrease. According to the Tl-201 scintigraphy findings, patients were divided in four groups: ischemia, necrosis, mixed and normal. The QRS score was significantly lesser in the normal group but there were no significant diferences between the other groups. CONCLUSION: The new score has a high sensitivity in diagnosing the severity of CAD and the presence of myocardial ischemia.

Özet

AMAÇ: Çalışmamızda iskeminin yeni bir göstergesi olarak ileri sürülen "yeni QRS skoru"nun koroner arter hastalığının (KAH) tanısı, ciddiyeti ve miyokard perfüzyon bozukluğu derecesi ile ilişkisini araştırmayı amaçladık. GEREÇ VE YÖNTEM: Bruce protokolüne göre egzersiz testi uygulanarak pozitif sonuç saptan an ya da egzersiz testi negatif olmakla beraber, devam eden angina yakınmaları olan 184 hastaya koroner anjiyografi ve Tl-201 sintigrafisi uygulandı. Yaş ortalaması 56.7±10.4 (yaş aralığı 30-81) olan olguların 47'si kadın, 137'si erkekti. Koroner anjiyogra fi bulgularına göre hastalar tek damar hastalığı (TDH), iki damar hastalığı (İDH), üç damar hastalığı (ÜDH) ve kontrol grubu (KG) olmak üzere 4 gruba ayrıldı. Her bir grupta hesaplanan QRS skorları egzersiz stres testinin klasik bir göstergesi olan ST segment depresyonu ile karşılaştırıldı. QRS skorunu hesaplamak için aVF ve V5 derivasyonlarındaki Q, R ve S dalgaları izoelektrik çizgiden itibaren tek tek ölçüldü; istirahat ve hemen egzersiz sonrası değerler birbirinden çıkartıldı. Elde edilen Delta değerleri (DeltaR-DeltaQ-DeltaS) aVF + (DeltaR-DeltaQ-DeltaS) V5 s eklinde toplanarak QRS skoru hesaplandı. BULGULAR: QRS skorlamasında 1.5 ve üzerindeki değerler normal olarak ele alındığında (cut-off değeri:1.5), koroner arter hastalığını tanımada QRS skorunun duyarlılığı ST segment çökmesinden üstün bulunurken (sırası ile %82, %71, p<0.01), özgüllük (%75, %73) ve pozitif kestirim değeri (%89, %85) arasında istatistiksel açıdan anlamlı fark saptanmadı. QRS skoru duyarlılığı özellikle tek damar hastalığını tanımada ST segment çökmesinden be l irgin derecede farklı bulundu (sırası ile %67, %58 p<0.05). Tıkalı damar sayısı arttıkça QRS skorunun azaldığı tespit edildi.Tl-201 sintigrafi sonuçlarına göre ise hastalar iskemi, nekroz, karışık ve normal olmak üzere 4 ayrı grupta tekrar değerlendirildi . Tüm gruplarda hesaplanan QRS skoru normal grupdan anlamlı derecede düşük bulunurken, 3 hasta grubunun kendi arasında istatistiksel fark tespit edilmedi. SONUÇ: Bu yeni skorun koroner arter hastalığının ciddiyetini ve miyokard iskemisi varlığını tespit etmede yüksek duyarlık ile kullanılabileceği kanısına varıldı.

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Cite This Article

ÇELİK, S., HOBİKOĞLU, G., AKGÖZ, H., ÜNAL, Ş., TERZİ, S., ÖKMEN, E., AKSOY, M., TAYYARECİ, G., ERSEK, B., ULUSOY, T. (2001). The new exercise QRS score in detecting the severity of coronary artery disease and its relationship with myocardial perfusion. MN Kardiyoloji, Cilt: 8 - Sayı: 1, 23–28. https://ajindex.com/articles/297774

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