Journals / MN Kardiyoloji / 2006 / Cilt: 13 - Sayı: 4

Effect of presence of metabolic syndrome on plasma adiponectin levels in women with abdominal obesity

Abdominal obezitesi bulunan kadınlarda metabolik sendrom varlığının plazma adiponektin düzeyleri üzerine etkisi

Pages
241–244
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings suggest that abdominal obesity is determinant of adiponectin levels.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Adiponectin is released from adipose tissue and has antidiabetic, antiatherosclerotic, antiinflammatory effects and its level decreases in coronary artery disease, NIDDM, metabolic syndrome.
📊
Key Findings & Data:Materials and Methods: Our population includes 84 women who were admitted to Gazi University Hospital outpatient clinics, with cardiac symptoms.
💡
Conclusion & Impact:These findings suggest that abdominal obesity is determinant of adiponectin levels.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Obezite · Metabolik hastalıklar · Adiponektin

Abstract

Aim: Adiponectin is released from adipose tissue and has antidiabetic, antiatherosclerotic, antiinflammatory effects and its level decreases in coronary artery disease, NIDDM, metabolic syndrome. The aim of this study is to evaluate the effect of presence of metabolic syndrome on plasma adiponectin levels in women with abdominal obesity. Materials and Methods: Our population includes 84 women who were admitted to Gazi University Hospital outpatient clinics, with cardiac symptoms. Height, weight, waist circumference, hip circumference, Body mass index (BMI), Waist/Hip ratio(WHR)) were measured. Plasma concentrations of adiponectin were measured by using radioimmunoassay technique. The patients were classified into 2 groups depending on whether they have metabolic syndrome or not according to the NCEP ATP III panel. Results: Adiponectin levels, waist circumference, VKI and waist/hip ratio results were similar for women with and without metabolic syndrome. TG, HDL, fasting blood glucose parameters were found to be statistically different between two groups. Conclusion: In this study adiponectin levels were similar in women with abdominal obesity independent of the presence of metabolic syndrome. These findings suggest that abdominal obesity is determinant of adiponectin levels.

Özet

Amaç: Adiponektin, yağ dokusundan salınan, inflamasyon, ateroskleroz ve diabetes mellitus a (DM) karşı koruyucu etkisi olan, koroner arter hastalığı, tip II DM, Metabolik sendrom gibi durumlarda plazma düzeyi azalan protein özelliğinde bir maddedir. Bu çalışma abdominal obezitesi olan kadınlarda metabolik sendrom varlığının plazma adiponektin düzeyleri üzerine etkisini değerlendirmek amacıyla planlandı. Gereç ve Yöntem: Gazi Üniversitesi Kardiyoloji polikliniklerine kardiyak yakınma için başvuran 84 kadın çalışmaya alındı. Hastaların boy, kilo ölçümleri alınarak vücut kitle indeksi (VKI) hesaplandı, kalça çevresi, bel çevresi ölçülerek Bel çevresi/kalça çevresi oranı hesaplandı. Çalışmaya alınan hastaların en az 8 saatlik gece açlık sonrası venöz kan örnekleri alındı, plazma adiponektin düzeyleri RIA yöntemi ile çalışıldı. Hastalar NCEP ATP III kriterlerine göre metabolik sendrom varlığına göre iki gruba ayrıldı. Bulgular: Tüm kadınlarda abdominal obezite mevcuttu. İki grup benzer bel, kalça çevresi, bel çevresi/kalça çevresi oranı, VKI değerlerine sahipti. Metabolik sendrom bulunan kişilerde TG ve AKŞ değerleri yüksek iken, HDL ise beklenildiği üzere daha düşük düzeylerdeydi. Adiponektin düzeyleri ise metabolik sendromu olan ve olmayan kadınlarda benzer bulundu. Sonuç: Bu çalışmada metabolik sendromu olan ve olmayan kişilerde adiponektin düzeylerinin benzer değerlerde saptanmasında abdominal obezite varlığının esas belirleyici olduğu gözlendi.

🔖

Cite This Article

TAÇOY, G., YAZICI, G., ÇENGEL, A., ELBEG, S., ABACI, A. (2006). Effect of presence of metabolic syndrome on plasma adiponectin levels in women with abdominal obesity. MN Kardiyoloji, Cilt: 13 - Sayı: 4, 241–244. https://ajindex.com/articles/297522

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Trujillo ME, Scherer PE. Adiponectin- journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. Journal of Internal Medicine 2005; 257:167-75.
  2. Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose spesific gene dysregulated in obesity. J Biol Chem 1996 3; 271:10697-703.
  3. Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999; 257:79-83.
  4. Ryo M, Nakamura T, Kihara S, et al. Adiponectin as a Biomarker of the Metabolic Syndrome. Circ J 2004; 68:975-81.
  5. Fruebis J, Tsao TS, Javorschi S, et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci U S A 2001 Feb 13; 98:2005-10.
  6. Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001; 7:941 -6. Onat A, Dönmez K, Sansoy V. Bedeni Hareketsizlik Kadınlarda Artma Eğiliminde: TEKHARF Çalışması Kohortu 1990-95 Verilerinin Analizi -(Investigations Rising Trend in Physical Inactivity in Turkish Women: Analysis of 1990-1995 Data on nationwide Sample Cohort). Türk Kardiyol Dem Arş 1996; 24:0-0.
  7. Dietz JJ, Iglesias P. The role of the novel adipocyte-derived hormone adipoectin in human disease. Eur J Endocrinol. 2003; 148:293-300.
  8. Ukkola O, Santaniemi M. Adiponectin: a link between excess adiposity and associated comorbidities? J Mol Med 2002; 80:696-702.
  9. Cnop M, Havel PJ, Utzschneider KM, et al. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 2003; 46:459-69.
  10. Ryan AS, Berman DM, Nicklas BJ, et al. Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity. Diabetes Care. 2003; 26:2383-8.
  11. Tschritter O, Fritsche A, Thamer C, et al. Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes 2003; 52:239-43.
  12. Yatagai T, Nagasaka S, Taniguchi A, et al. Hypoadiponectinemia is associated with visseral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus. Meta­bolism. 2003; 52:1274-8.
  13. Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectine mia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin.