Journals / MN Kardiyoloji / 2015 / Cilt: 22 - Sayı: 1

Evaluation of plasma brain natriuretic peptid levels in patients with isolated left bundle branch block and preserved left ventricular systolic function

Sol ventrikül fonksiyonları korunmuş olan izole sol dal bloklu hastalarda plazma beyinnatriüretik peptid düzeylerinin değerlendirilmesi

Pages
7–13
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Determini tomatic individuals with isolated LBBB can contribute to the pre-detection of subclinical LV dysfunctions

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In this study, we aimed to determine the effect of isolated left bundle branch block (LBBB) o with isolated LBBB and preserved left ventricular (LV) systolic function.
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Key Findings & Data:Material and Method: This study was carried out by measuring plasma BNP levels in the 42 patients dia 30 healthy controls.
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Conclusion & Impact:Determini tomatic individuals with isolated LBBB can contribute to the pre-detection of subclinical LV dysfunctions
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: In this study, we aimed to determine the effect of isolated left bundle branch block (LBBB) o with isolated LBBB and preserved left ventricular (LV) systolic function. Material and Method: This study was carried out by measuring plasma BNP levels in the 42 patients dia 30 healthy controls. All subjects (n=72) were classified in according to the median value of the plasm (BNP≤14.6 pg/mL) and high BNP group (BNP>14.6 pg/mL). Results: Mean plasma BNP level was higher in isolated LBBB group than in the control group (30.16±22.0 p=0.003). Plasma BNP levels showed a significantly positive correlation with age (r:0.35, p=0.002) and In the logistic regression analysis, it was detected that isolated LBBB (OR, 3.91 [95% CI,1.08 - 14.16 [95%CI,1.04 - 1.16], p= 0.001) were independent predictors of high plasma BNP level. Conclusion: This study shows that plasma BNP level increases in patients with isolated LBBB. Determini tomatic individuals with isolated LBBB can contribute to the pre-detection of subclinical LV dysfunctions

Özet

Amaç: Bu çalışmada biz sol ventrikül sistolik fonksiyonları korunmuş hastalarda izole sol dal bloğunun (SDB) plazma beyin natriüretik peptid (BNP) düzeylerine olan etkisini belirlemeyi amaçladık. Gereç ve Yöntem: Bu çalışma izole sol dal bloğu olan 42 hasta ve 30 sağlıklı kontrol grubunda plazma BNP düzeyleri ölçülerek yapıldı. Çalışma popülasyonu plazma BNP düzeylerinin ortanca değerine göre yüksek (BNP grubu BNP≤14,6 pg/mL) ve düşük BNP grubu (BNP≤14,6 pg/mL) olarak 2 gruba ayrıldı. Bulgular: Ortalama plazma BNP düzeyi kontrol grubuna kıyasla izole sol dal bloklu hastalarda daha yüksek idi (30,16±22,04 pg/mL vs 15,81±14,24 pg/mL, p=0,003). Plazma BNP düzeyleri yaş ve QRS süresi ile önemli ölçüde pozitif korelasyon gösterdi (r:0,35, p=0,002 ve r:0,39, p=0,001). Logistik regresyon analizinde, yaş ve QRS süresinin yüksek BNP düzeyinin bağımsız prediktörleri olduğu saptandı (OR, 3,91 [%95 CI,1,08 - 14,16], p= 0,038) ve yaş (OR, 1,10 [%95CI,1,04 - 1,16], p=0,001). Sonuç: Bu çalışma izole SDB’lu hastalarda plazma BNP düzeyinin yükseldiğini göstermektedir. İzole SDB’lu asemptomatik hastalarda plazma BNP düzeyinin belirlenmesi subklinik sol ventrikül (SV) disfonksiyonunun önceden saptanmasına katkıda bulunabilir.

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Cite This Article

HAMUR, H., AÇIKEL, M., BAKIRCI, E. M., DEĞİRMENCİ, H., DUMAN, H., DEMİRELLİ, S., EROL, F., TAŞ, M. H., AKSAKAL, E., KARAKELLEOĞLU, Ş., KÜÇÜKSU, Z. (2015). Evaluation of plasma brain natriuretic peptid levels in patients with isolated left bundle branch block and preserved left ventricular systolic function. MN Kardiyoloji, Cilt: 22 - Sayı: 1, 7–13. https://ajindex.com/articles/297348

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