Journals / MN Kardiyoloji / 2018 / Cilt: 25 - Sayı: 1

The Relationship Between Ventricular Repolarization Dispersion and fQRS with the Presence and Severity of Metabolic Syndrome

Metabolik Sendrom Varlığı ve Şiddeti ile Ventriküler Repolarizasyon Dispersiyonu ve QRS Fragmantasyonu İlişkisi

Pages
8–12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, further studies with prospective design are needed to evaluate the patients with metabolic syn- drome for the probability of ventricular arrhythmias.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Among metabolic syndrome population, electrophysiological abnormalities including QT prolongation and the higher inci- dence of fragmented QRS (fQRS) have been reported.
📊
Key Findings & Data:Material and Method: In this cross-sectional study, a total of 110 patients (32 male, mean age 57.4 ± 7.9 years) who were admitted to cardiology outpatient clinics and have fulfilled the criteria of metabolic syndrome were included.
💡
Conclusion & Impact:However, further studies with prospective design are needed to evaluate the patients with metabolic syn- drome for the probability of ventricular arrhythmias.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Among metabolic syndrome population, electrophysiological abnormalities including QT prolongation and the higher inci- dence of fragmented QRS (fQRS) have been reported. Therefore, we aimed to evaluate the QT duration, Tp-e interval, Tp-e/QT ratio and fQRS in patients with metabolic syndrome, and to investigate if these indices are related to the metabolic syndrome severity represented as the number of metabolic syndrome criteria. Material and Method: In this cross-sectional study, a total of 110 patients (32 male, mean age 57.4 ± 7.9 years) who were admitted to cardiology outpatient clinics and have fulfilled the criteria of metabolic syndrome were included. Also, 97 patients without metabolic syndrome (35 male, mean age 56.3 ± 10.3 years) were selected as control group. Results: The QTc, Tp-e intervals and Tp-e/QTc ratio were significantly increased in metabolic syndrome group compared to the control group (p=0.004, p<0.001, p<0.001; respectively). Also, the incidence of fQRS was significantly higher in the metabolic syndrome group (p=0.003). The QTc, Tp-e intervals and Tp-e/QTc ratio showed moderate and significant positive correlation with the number of meta- bolic syndrome criteria (p<0.001). fQRS showed weak but significant positive correlation with the number of metabolic syndrome pa- rameters (p=0.009). Conclusions: The QTc, Tp-e intervals and Tp-e/QTc ratio are prolonged in patients with metabolic syndrome and the incidence of fQRS is higher in such population. However, further studies with prospective design are needed to evaluate the patients with metabolic syn- drome for the probability of ventricular arrhythmias.

Özet

Amaç: Metabolik sendrom hastalarında, QT uzaması ve QRS fragmantasyonu (fQRS) sıklığında artışı da içeren elektrofizyolojik anor- mallikler daha önce bildirilmiştir. Bu nedenle, metabolik sendrom hastalarında QT süresi, Tp-e aralığı, Tp-e/QT oranı ve fQRS sıklığı ile bu parametrelerin metabolik sendrom kriter sayısı olarak ifade edilen metabolik sendrom şiddeti ile ilişkisini değerlendirmeyi amaçladık. Gereç ve Yöntem: Bu kesitsel çalışmaya kardiyoloji polikliniğine başvuran ve metabolik sendrom kriterlerini karşılayan 110 hasta (32 er- kek, ortalama yaş 57,4 ± 7,9 yıl) dahil edildi. Ayrıca, metabolik sendrom olmayan 97 gönüllü kontrol (35 erkek, ortalama yaş 56,3 ± 10,3 yıl) grubu olarak dahil edildi. Bulgular: QTc süresi, Tp-e aralığı ve Tp-e/QT oranı metabolik sendrom hastalarında anlamlı derecede uzun bulundu (p=0,004, p<0,001 ve p<0,001). Ayrıca, fQRS metabolik sendrom hastalarında daha sık gözlemlendi (p=0,003). QTc süresi, Tp-e aralığı ve Tp-e/QT oranının metabolik sendrom kriter sayısıyla orta düzeyde anlamlı korelasyon gösterdiği bulundu (p<0,001). fQRS’un ise metabolik sendrom para- metreleriyle zayıf ama anlamlı bir korelasyonu mevcuttu (p=0,009). Sonuç: QTc süresi, Tp-e aralığı ve Tp-e/QT oranı metabolik sendrom hastalarında uzamıştır ve de fQRS sıklığı artmıştır. Fakat metabolik sendrom ile ventriküler aritmilerin ilişkisini ileriye dönük çalışmalarla değerlendirmek gerekir.

🔖

Cite This Article

BALCI, K. G., AKBOĞA, M. K., YILMAZ, S., ERBAY, İ., YAKUT, İ., BALCI, M. M., MADEN, O., DURU, H. N. S., SELÇUK, M. T. (2018). The Relationship Between Ventricular Repolarization Dispersion and fQRS with the Presence and Severity of Metabolic Syndrome. MN Kardiyoloji, Cilt: 25 - Sayı: 1, 8–12. https://ajindex.com/articles/297252

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (8)

  1. Third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 2002;106(25): 3143-421. Ford ES. The metabolic syndrome and mortality from car- diovascular disease and all-causes: findings from the National Health and Nutrition Examination Survey II Mortality Study. Atherosclerosis 2004;173(2):309-14.
  2. Isomaa B, Almgren P, Tuomi T, et al. Cardiovascular mor- bidity and mortality associated with the metabolic syn- drome. Diabetes Care 2001;24(4):683-9.
  3. Kim HK, Kim CH, Ko KH, Park SW, Park JY, Lee KU. Variable association between components of the metabolic syn- drome and electrocardiographic abnormalities in Korean adults. Korean J Intern Med 2010;25(2):174-80. 3 rd, Prineas R, Daviglus ML, et al. Prevalence of Walsh JA electrocardiographic abnormalities in a middle-aged, bira- cial population: Coronary Artery Risk Development in Young Adults study. J Electrocardiol 2010;43(5):385.e1-9. De Bacquer D, Martins Pereira LS, De Backer G, De Henauw S, Kornitzer M. The predictive value of electrocardio- graphic abnormalities for total and cardiovascular disease mortality in men and women. Eur Heart J 1994;15(12): 1604-10.
  4. Machado DB, Crow RS, Boland LL, Hannan PJ, Taylor HA Jr, Folsom AR. Electrocardiographic findings and incident coronary heart disease among participants in the Atherosclerosis Risk in Communities (ARIC) study. Am J Cardiol 2006;97(8):1176-181.
  5. Oner E, Erturk M, Birant A, et al. Fragmented QRS com- plexes are associated with left ventricular systolic and di- astolic dysfunctions in patients with metabolic syndrome. Cardiol J 2015;22(6):691-8.
  6. Chinali M, Devereux RB, Howard BV, et al. Comparison of cardiac structure and function in American Indians with and without the metabolic syndrome (the Strong Heart Study). Am J Cardiol 2004;93(1):40-4.
  7. Ma Y, Tseng PH, Ahn A, et al. Cardiac Autonomic Alteration and Metabolic Syndrome: An Ambulatory ECG-based Study in A General Population. Sci Rep 2017;7:44363. Karaagac K, Emul A, Tenekecioglu E, et al. The Effects of Metabolic Syndrome on TpTe Interval and TpTe/QT Ratio in Patients with Normal Coronary Arteries. Eurasian J Med 2014;46(3):182-6.
  8. Gupta P, Patel C, Patel H, et al. T(p-e)/QT ratio as an index of arrhythmogenesis. J Electrocar¬diol 2008; 41(6): 567- 574. Igarashi M, Tada H, Yamasaki H, et al. Fragmented QRS Is a Novel Risk Factor for Ventricular Arrhythmi