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Journals / MN Kardiyoloji / 2020 / Cilt: 27 - Sayı: 3

Can Mean Platelet Volume Be an Independent Predictor for Stroke in Patients with Atrial Fibrillation?

Ortalama Trombosit Hacmi Atriyal Fibrilasyonlu Hastalarda İnme İçin Bağımsız Bir Öngördürücü Olabilir mi?

Güney ERDOĞAN
UĞUR ARSLAN
Mustafa YENERÇAĞ
Diyar KÖPRÜLÜ
Osman ŞAHİN
Pages
147–152
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In addition, high left atrial volume index values may determine the risk of stroke and may be a marker of decision for anticoagulant therapy as mean platelet volume.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Despite the great progression in the medical and invasive treatment of atrial fibrillation in recent years, the risk of stroke is still a major threat.
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Key Findings & Data:There are patients with stroke despite low CHA2DS2VASc scores and consequently giving rise to the possibility of additional risk factors.
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Conclusion & Impact:In addition, high left atrial volume index values may determine the risk of stroke and may be a marker of decision for anticoagulant therapy as mean platelet volume.
🔬Design:Research Article
📍Scope:2017 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Despite the great progression in the medical and invasive treatment of atrial fibrillation in recent years, the risk of stroke is still a major threat. There are patients with stroke despite low CHA2DS2VASc scores and consequently giving rise to the possibility of additional risk factors. There are some studies indicating that mean platelet volume determines the prognosis and risk in patients with a stroke. In this study, our aim was to investigate the mean platelet volume levels which may be used as an early predictor of thromboembolism in acute stroke patients with atrial fibrillation. Material and Method: This retrospective crossectional study was conducted between September 2017 and March 2019 using the emergency department and stroke center. Mean platelet volume determination was made within 24 hour following the onset of stroke. The left atrial volume index was categorized as normal ( 9.18 fl) was significantly associated with the occurrence of stroke [odds ratio 4,066, 95% confidence interval 2.292-7.216, p<0.001]. In receiver-operating characteristic (ROC) curve analysis, the value for mean platelet volume levels to detect stroke with a sensitivity of 72% and specificity of 60% was 9.18 fl. Conclusion: Our study showed that high mean platelet volume levels are associated with an increased risk of stroke in patients with atrial fibrillation. In addition, high left atrial volume index values may determine the risk of stroke and may be a marker of decision for anticoagulant therapy as mean platelet volume.

Özet

Giriş: Son yıllarda atriyal fibrilasyonun tıbbi ve invazif tedavisindeki büyük ilerlemelere rağmen, inme riski halen büyük bir tehdittir. Düşük CHA2DS2VASc skorlarına rağmen inmeli hastaların var olması ek risk faktörleri olasılığını akla getirmektedir. İnmeli hastalarda ortalama trombosit hacminin prognoz ve riski belirlediğini gösteren bazı çalışmalar vardır. Bu çalışmada amacımız, atriyal fibrilasyonlu akut inmeli hastalarda tromboembolizmin erken bir prediktörü olarak kullanılabilecek ortalama trombosit hacmi düzeylerini araştırmaktır. Gereç ve Yöntem: Bu retrospektif kesitsel çalışmaya, Eylül 2017- Mart 2019 arasında acil servise başvuran inme tanılı hastalar alındı. İnme başlangıcından sonraki 24 saat içinde ortalama trombosit hacmi belirlemesi yapıldı. Sol atriyal volüm indeksi normal ( 9,18 fl) inme oluşması ile anlamlı olarak ilişkili idi [risk oranı; 4,066, % 95 güven aralığı; 2,292-7,216, p<0,001]. ROC eğrisi analizinde %72 duyarlılık ve % 60 özgüllük ile inme saptanması için ortalama trombosit hacmi seviyelerinin gerekli eşik değeri 9.18 fl olarak bulundu. Sonuç: Çalışmamız, yüksek ortalama trombosit hacminin atriyal fibrilasyonlu hastalarda artmış inme riski ile ilişkili olduğunu göstermiştir. Ek olarak, yüksek sol atriyal volüm indeksi değerleri inme riskini belirleyebilir ve ortalama trombosit hacmi gibi antikoagülan tedavi için kararın bir belirleyicisi olabilir

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Cite This Article

ERDOĞAN, G., ARSLAN, U., YENERÇAĞ, M., KÖPRÜLÜ, D., ŞAHİN, O. (2020). Can Mean Platelet Volume Be an Independent Predictor for Stroke in Patients with Atrial Fibrillation?. MN Kardiyoloji, Cilt: 27 - Sayı: 3, 147–152. https://ajindex.com/articles/297181

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