Journals / MN Oftalmoloji / 2011 / Cilt: 18 - Sayı: 1

Type 2 diabetes mellitus and specular microscopic changes of cornea

Tip 2 diabetes mellitus ve korneanın speküler mikroskobik değişiklikleri

Pages
4–7
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Corneal endothelium of type two diabetes patients did not differ significantly but if it is considered as an indicator of severity of diabetes, patients with proliferative diabetic retinopathy when compared with non proliferative diabetic retinopathy developed patients cell hexagonality and variation coefficient were significantly changed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Endothelial characteristics of the patients with diabetes mellitus compared with healthy controls by using specular microscopy.
📊
Key Findings & Data:Material and Method: Both of the corneas of 56 patients with type 2 diabetes mellitus considering whether having proliferative diabetic retinopathy or not were compared with 30 control patients by using specular microscopy.
💡
Conclusion & Impact:Conclusion: Corneal endothelium of type two diabetes patients did not differ significantly but if it is considered as an indicator of severity of diabetes, patients with proliferative diabetic retinopathy when compared with non proliferative diabetic retinopathy developed patients cell hexagonality and variation coefficient were significantly changed.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Endothelial characteristics of the patients with diabetes mellitus compared with healthy controls by using specular microscopy. Material and Method: Both of the corneas of 56 patients with type 2 diabetes mellitus considering whether having proliferative diabetic retinopathy or not were compared with 30 control patients by using specular microscopy. Results: Patients' cell density, coefficient of variation, hexagonality and central corneal thickness compared with the control group did not differ significantly (p=0.222, p=0.428, p=0.874, p=0.749). At comparison of proliferative–nonproliferative retinopathy groups there were no significant difference between cell density and central corneal thickness (p= 0.705, p=0.376), but variation coefficient and hexagonality comparisons were significantly different (p=0.06, p=0.037). Conclusion: Corneal endothelium of type two diabetes patients did not differ significantly but if it is considered as an indicator of severity of diabetes, patients with proliferative diabetic retinopathy when compared with non proliferative diabetic retinopathy developed patients cell hexagonality and variation coefficient were significantly changed.

Özet

Amaç: Diabetes mellituslu hastaların endotel özellikleri speküler mikroskopi kullanılarak sağlıklı kontrollerle karşılaştırılmıştır. Gereç ve Yöntem: Tip 2 diabetes mellituslu 56 hastanın her iki göz korneaları proliferatif diyabetik retinopati bulguları olup olmadığı dikkate alınarak, 30 kontrol hastasının her iki göz kornealarıyla speküler mikroskopi kullanılarak karşılaştırıldı. Bulgular: Diabetes mellituslu hastaların hücre yoğunlukları, varyasyon katsayıları, hekzagonaliteleri ve santral kornea kalınlıkları kontrol grubu ile karşılaştırıldığında anlamlı fark bulunamadı (p=0,222; p=0,428; p=0,874; p=0,749). Proliferatif- nonproliferatif diyabetik retinopatili grupların karşılaştırılmasında hücre yoğunlukları ve santral kornea kalınlıkları arasında anlamlı fark bulunmazken (p=0,705; p=0,376), varyasyon katsayıları ve hekzagonalite karşılaştırmasında anlamlı fark bulundu (p=0,06; p=0,037). Sonuçlar: Tip 2 diabetes mellitusu olan hastaların kornea endoteli normal hastalardan farklı bulunmamıştır ancak diyabetin şiddetinin bir göstergesi olarak değerlendirilecek olursa proliferatif diyabetik retinopati geliştirmiş olan hastaların nonproliferatif diyabetik retinopatili hastalarla karşılaştırıldığında hücre hekzagonaliteleri ve varyasyon katsayıları anlamlı olarak değişmiştir.

🔖

Cite This Article

ATALAY, K., KADIOĞLU, E. (2011). Type 2 diabetes mellitus and specular microscopic changes of cornea. MN Oftalmoloji, Cilt: 18 - Sayı: 1, 4–7. https://ajindex.com/articles/296815

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (9)

  1. Kalousová M, Krha J, Zıma T. Advanced Glycation End-Pro - ducts and Advanced Oxidation Protein Products in Patients With Diabetes Mellitus. Physiol Res 2002;51:597-604
  2. Uemura S, Matsushita H, Li W, Glassford AJ, Asagami T, Lee KH, Harrison DG, Tsao PS. Diabetes Mellitus Enhances Vascular Matrix Metalloproteinase Activity Role of Oxidative Stress Circ Res 2001;88:1291-8
  3. McNamara NA, Brand RJ, Polse KA, Bourne WM. Corneal function during normal and high serum glucose levels in diabetes. Invest Ophthalmol Vis Sci 1998;39:3-17
  4. Jurkunas U, Colby K. Evaluation of the Corneal Endothelium Techniques in Ophthalmol 2005;3:19-26
  5. Schultz RO, Matsuda M, Yee RW, Edelhauser HF, Schultz KJ. Corneal endothelial changes in type I and type II diabetes mellitus. Am J Ophthalmol 1984;98:401-10
  6. Larsson LI, Bourne WM, Pach JM, Brubaker RF. Structure and Function of the Corneal Endothelium in Diabetes Mellitus Type I and Type II. Arch Ophthalmol 1996;114:9-14
  7. Inoue K, Kato S, Inoue Y, Amano S, Oshika T. The Corneal En dot heli um and Thickness in Type II Diabetes Mellitus. Jpn J Ophthalmol 2002;46:65-9 8. Bahn CF, Falls HF, Varley GA, Meyer RF, Edelhauser HF, Bourne WM. Classification Of Corneal Endothelial Disorders Based On Neural Crest Origin. Ophthalmol 1984;91:558-63
  8. Sato E, Mori F, Igarashi S, Abiko T, Takeda M, Ishiko S, Yoshida A. Corneal Advanced Glycation End Products Increase in Patients with Proliferative Diabetic Retinopathy. Diabetes Care 2001;24:479-82
  9. Roszkowska AM, Tringali CG, Colosi P, Squeri CA, Ferreri G. Corneal endothelium evaluation in type I and type II diabetes mellitus. Ophthalmologica 1999;213:258-61.