Journals / MN Oftalmoloji / 2012 / Cilt: 19 - Sayı: 2

Investigation of the topographic correlation between visual field sensitivities and peripapillary retinal nerve fiber layer thickness and optic nerve head parameters

Peripapiller retina sinir lifi kalınlığının ve optik sinir başı parametrelerinin görme alanı hassasiyeti ile topografik uyumlarının incelenmesi

Pages
89–96
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Topographic correlation between sectoral rim area and corresponding sectoral RNFL thickness is low in these patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: To investigate the topographic correlation between visual field sensitivities and peripapillary retinal nerve fiber layer (RNFL) thickness together with optic nerve head (ONH) parameters.
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Key Findings & Data:Material and Method: Two hundred and nine subjects (62 with ocular hypertension, 65 with glaucoma suspect and 82 primary open angle glaucoma) were studied retrospectively.
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Conclusion & Impact:Topographic correlation between sectoral rim area and corresponding sectoral RNFL thickness is low in these patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: To investigate the topographic correlation between visual field sensitivities and peripapillary retinal nerve fiber layer (RNFL) thickness together with optic nerve head (ONH) parameters. Material and Method: Two hundred and nine subjects (62 with ocular hypertension, 65 with glaucoma suspect and 82 primary open angle glaucoma) were studied retrospectively. ONH configuration was analyzed by Heidelberg Retinal Tomograph III (HRT III), RNFL was analyzed by Spectralis Optical Coherence Tomography (OCT). A perimetric nerve fiber bundle map was built by dividing the visual field area into 6 sectors. Topographic correlation between visual field sensitivity and RNFL thickness as well as neuroretinal rim area were analyzed. Results: In our cohort of patients, inferotemporal and superotemporal RNFL thickness measurements had the strongest associations with superior arcuate and inferotemporal sector (R2 values 0.19 and 0.15, respectively). Only a weak correlation was observed between superior arcuate visual field and inferotemporal rim area (R2:0.07). Moreover, global visual field sensitivities were found to be better correlated with global RNFL thickness than that of ONH parameters. No correlation was observed between the most of the RNFL thickness and rim area at corresponding ONH sectors. Only a weak association was detected between the inferotemporal RNFL thickness and the rim area (R2:0.068, p<0.001). Conclusions: Sectoral RNFL thickness measurements of patients with ocular hypertension, glaucoma suspect and early glaucoma are more significantly correlated topographically with the corresponding visual field indices than rim area measurements. Topographic correlation between sectoral rim area and corresponding sectoral RNFL thickness is low in these patients.

Özet

Amaç: Görme alanı testinden elde edilen hassasiyet değerleri ile peripapiller retina sinir lifi tabakası (RSLT) kalınlık ölçümlerinin ve optik sinir başı (OSB) parametrelerinin topografik uyumunun incelenmesi. Gereç ve Yöntem: Altmış ikisi oküler hipertansif, 65’i şüpheli glokom ve 82’si primer açık açılı glokom olgusuna ait kayıtlar (toplam 209 olgu) retrospektif olarak incelendi. OSB topografisi, Heidelberg Retinal Tomografi III (HRT III) ile, RSLT ölçümleri Spectralis Optik Koherans Tomografi ile yapıldı. Görme alanı 6 bölgeye ayrılarak perimetrik sinir lifi haritası oluşturuldu. Görme alanı bölgelerindeki hassasiyet değerleri ile eşlenik nöroretinal rim alanı ve RSLT ölçümleri arasındaki uyum Pearson korelasyon testi ile analiz edildi. Bulgular: Olgularımızda inferotemporal RSLT kalınlığı ile süperior arkuat görme alanı arasında ve süperotemporal RSLT kalınlığı ile inferotemporal görme alanı arasında korelasyon mevcuttu (R2: sırasıyla 0,19 and 0,15). GA ile OSB arasında tespit edilebilen tek ilişki ise süperior arkuat görme alanı ile inferotemporal rim alanı arasındaki zayıf korelasyondu (R2:0,07). Ayrıca, global görme alanı hassasiyet değerleri ile global RSLT ölçümleri arasındaki korelasyon, global görme alanı ile global OSB parametreleri arasındaki korelasyondan daha yüksek bulundu. Bunun yanında, RSLT sektörlerindeki kalınlık ölçümleri ile OSB sektörlerindeki rim alanı değerleri arasındaki korelasyon analizinde tespit edilebilen tek anlamlı ilişki inferotemporal sektördeki zayıf korelasyondu (R2:0,068). Sonuç: Oküler hipertansif, glokom şüphesi ve erken evre glokom olgularında RSLT kalınlık ölçümlerinin görme alanı ile topografik uyumu, nöroretinal rim ile görme alanının uyumundan daha yüksektir. Bu olgu grubunda, OSB parametreleri ve RSLT arasındaki topografik uyum düşüktür.

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Cite This Article

ÇANKAYA, A. B., KARAHAN, S., YILMAZBAŞ, P., ÖZTÜRK, F. (2012). Investigation of the topographic correlation between visual field sensitivities and peripapillary retinal nerve fiber layer thickness and optic nerve head parameters. MN Oftalmoloji, Cilt: 19 - Sayı: 2, 89–96. https://ajindex.com/articles/295715

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References (12)

  1. Sommer A, Katz J, Quigley HA, et al. Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. Arch Ophthalmol 1991;109:77-83
  2. Tuulonen A, Lehtola J, Airaksinen PJ. Nerve fiber layer defects with normal visual fields: do normal optic disc and normal visual field indicate absence of glaucomatous abnormality? Ophthalmology 1993;100:587-97
  3. Hood DC, Kadron RH. A framework for comparing structural and functional measures of glaucomatous damage. Prog Retin Eye Res 2007;26:688-710
  4. Zangwill LM, Bowd C, Weinreb RN. Evaluating the optic disc and retinal nerve fiber layer in glaucoma. II: Optical image analysis. Semin Ophthalmol 2000;15:206-20
  5. Chen TC. Spectral domain optical coherence tomography in glaucoma: qualitative and quantitative analysis of the optic nerve head and retinal nerve fiber layer (an AOS Thesis) Trans Am Ophthalmol Soc 2009;107:254-81
  6. Garway-Heath DF, Poinoosawmy D, Fitzke FW, Hitchings RA. Mapping the visual field to the optic disc in normal tension glaucoma eyes. Ophthalmology 2000;107:1809-15
  7. Weber J, Dannheim F, Dannheim D. The topographical relationship between optic disc and visual field in glaucoma. Acta Ophthalmol 1990;68:568-74
  8. Anton A, Yamagishi N, Zangwill L, Sample P, Weinreb R. Mapping structural to functional damage in glaucoma with standard automated perimetry and confocal scanning laser ophthalmoscopy. Am J Ophthalmol 1998;125:436-46
  9. Yalvac IS, Altunsoy M, Cansever S, Satana B, Eksioglu U, Duman S. The Correlation between visual field defects and focal nerve fiber layer thickness measured with optical coherence tomography in the evaluation of glaucoma. J Glaucoma 2009; 18:53-61 10. Bowd C, Zangwill LM, Medeiros FA, et al. Structure–function relationships using confocal scanning laser ophthalmoscopy, optical coherence tomography, and scanning laser polarimetry. Invest Ophthalmol Vis Sci 2006;47:2889-95
  10. Leung CK, Chong KK, Chan WM, et al. Comparative study of retinal nerve fiber layer measurement by StratusOCT and GDx VCC, II: structure/function regression analysis in glaucoma. Invest Ophthalmol Vis Sci 2005;46:3702-11
  11. Iester M, Traverso CE, De Feo F, et al. Correlation between frequency doubling technology and heidelberg retina tomograph. J Glaucoma 2005;14:368-74
  12. Leung CK, Medeiros FA, Zangwill LM, et al. American Chinese Glaucoma Imaging Study: A Comparison of the Optic Disc and Retinal Nerve Fiber Layer in Detecting Glaucomatous Damage. Invest Ophthal