SavedAdd your journal

Journals / MN Oftalmoloji / 2015 / Cilt: 22 - Sayı: 1

Retinal Pigment Epithelium Thickness Analysis with Optical Coherence Tomography in Patients with Vitiligo

Vitiligolu Hastalarda Retina Pigment Epitel Kalınlığının Optik Koherans Tomografi ile Analizi

Nilüfer İLHAN
Emine Nur RİFAİOĞLU
Özgür İLHAN
Mesut COŞKUN
Mutlu Cihan DAĞLIOĞLU
Esra Ayhan TUZCU
Hilal KAHRAMAN
Pages
30–33
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Although vitiligo affects the amount of pigment, it does not affect the thickness of RPE cells.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: To investigate the ocular findings of adult individuals with vitiligo and analysis of retinal pigment epithelium (RPE) thickness using optical coherence tomography (OCT).
📊
Key Findings & Data:Material and Method: The study was conducted prospectively and comprised 30 patients with vitiligo and 39 healthy individuals.
💡
Conclusion & Impact:Although vitiligo affects the amount of pigment, it does not affect the thickness of RPE cells.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: To investigate the ocular findings of adult individuals with vitiligo and analysis of retinal pigment epithelium (RPE) thickness using optical coherence tomography (OCT). Material and Method: The study was conducted prospectively and comprised 30 patients with vitiligo and 39 healthy individuals. A detailed ophthalmological examination was performed and also, thickness of RPE measurements was obtained using OCT. Results: The mean age of the patients with vitiligo was 37.5±15.5 (18-62 years), while the mean age of the control group was 38.6±11.0 (21-61 years). There were 40% periocular vitiligo lesions, 20% poliosis, 16.7% iris atrophy, 3.3% macular hypopigmented lesion in the vitiligo group. The mean thickness of RPE in patients with vitiligo and control group was 63.3±3.0 ?m and 64.3±1.7 ?m, respectively. There was no statistically significant difference between groups in terms of the mean thickness of the RPE (p=0.07). The mean thickness of RPE in patients with and without periocular vitiligo lesions was 63.0±3.1 ?m and 65.0±2.4 ?m, respectively. No statistically significant difference was detected between periocular involvement and the mean thickness of the RPE (p=0.06). Conclusion: Periocular skin lesions and poliosis are common in vitiligo, although hypopigmented lesions can be seen in the iris and retina. Although vitiligo affects the amount of pigment, it does not affect the thickness of RPE cells.

Özet

Amaç: Vitiligolu erişkin bireylerde eşlik eden göz bulgularının araştırılması ve optik koherans tomografi (OKT) ile retina pigment epitel (RPE) kalınlığı analizi. Gereç ve Yöntem: Vitiligolu 30 hasta ve sağlıklı 39 bireyin dahil edildiği çalışma prospektif olarak yürütüldü. Katılımcılar detaylı bir göz muayenesine tabi tutuldu, ayrıca OKT ile RPE kalınlık ölçümleri yapıldı.Bulgular: Vitiligolu hastaların yaş ortalaması 37,5±15,5 (18-62 yıl), kontrol grubunun yaş ortalaması ise 38,6±11,0 (21-61 yıl) idi. Vitiligo grubunun %40'ında perioküler vitiligo lezyonları, %20'sinde poliozis, %16,7'sinde iris atrofisi, %3,3'ünde makülada hipopigmente lezyon saptandı.Vitiligolu hastaların ve kontrol grubunun RPE kalınlık ortalamaları sırasıyla 63,3±3,0 µm ve 64,3±1,7 µm idi. Gruplar arasında RPE kalınlık ortalamaları açısından istatistiksel olarak fark saptanmadı (p=0,07). Perioküler vitiligo lezyonları olan ve olmayan hastaların RPE kalınlık ortalamaları sırasıyla 63,0±3,1 µm ve 65,0±2,4 µm idi. Perioküler tutulumu olanlar ve olmayanlar arasında RPE kalınlık ortalamaları açısından istatistiksel olarakfark saptanmadı (p=0,06).Sonuç: Vitiligoda perioküler cilt lezyonları ve poliozis sık görülmekle birlikte iris ve retinada hipopigmente lezyonlar da görülebilmektedir. Vitiligoher ne kadar pigment miktarını etkilese de, RPE hücrelerinin kalınlığını etkilememektedir.

🔖

Cite This Article

İLHAN, N., RİFAİOĞLU, E. N., İLHAN, Ö., COŞKUN, M., DAĞLIOĞLU, M. C., TUZCU, E. A., KAHRAMAN, H. (2015). Retinal Pigment Epithelium Thickness Analysis with Optical Coherence Tomography in Patients with Vitiligo. MN Oftalmoloji, Cilt: 22 - Sayı: 1, 30–33. https://ajindex.com/articles/295639

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Yu HS. Melanocyte destruction and repigmentation in vitiligo: a mo - del for nerve cell damage and regrowth. J Biomed Sci 2002;9:564-73.
  2. Parsad D, Pandhi R, Juneja A. Effectiveness of oral Ginkgo biloba in treating limited, slowly spreading vitiligo. Clin Exp Dermatol 2003; 28(3):285-7.
  3. Albert DM, Wagoner MD, Pruett RC, Nordlund JJ, Lerner AB. Viti li - go and disorders of the retinal pigment epithelium. Br J Ophthalmol 1983;67(3):153-56.
  4. Huggins RH, Janusz CA, Schwartz RA. Vitiligo: a sign of systemic di se ase. Indian J Dermatol Venereol Leprol 2006;72(1):68-71.
  5. Bulbul Baskan E, Baykara M, Ercan I, Tunali S, Yucel A. Vitiligo and ocular findings: a study on possible associations. J Eur Acad Dermatol Venereol 2006;20(7):829-33.
  6. Guerra L, Dellambra E, Brescia S, Raskovic D. Vitiligo: pathogenetic hypotheses and targets for current therapies. Curr Drug Metab 2010 1;11(5):451-67.
  7. Le Poole IC, Luiten RM. Autoimmune etiology of generalized vi- tiligo. Curr Dir Autoimmun 2008;10:227-43. Spritz RA. The genetics of generalized vitiligo. Curr Dir Autoimmun 2008;10:244-57.
  8. Serin D, Parlak AH, Alagöz G, Tırak E. Vitiligolu hastalarda göz bul - gu ları. MN Oftalmoloji 2007;14(3):181-3.
  9. Zengin N, Tol H, Gündüz K, Balevi Ş, Okudan S, Endoğru H. Viti li - go da göz bulguları. Selçuk Tıp Derg 1996;12(2):205-8.
  10. Albert DM, Nordlund JJ, Lerner AB. Ocular abnormalities occurring with vitiligo. Ophthalmology 1979;86:1145-60.
  11. Cowan CL Jr, Halder RM, Grimes PE, Chakrabarti SG, Kenney JA Jr. Ocu lar disturbances in vitiligo. J Am Acad Dermatol 1986;15(1):17- 24. Biswas G, Barbhuiya JN, Biswas MC, Islam MN, Dutta S. Clinical pat tern of ocular manifestations in vitiligo. J Indian Med Assoc 2003; 101(8):478-80.
  12. Wagoner MD, Albert DM, Lerner AB, Kirkwood J, Forget BM, Nord - lund JJ. New observations on vitiligo and ocular disease. Am J Opht - hal mol 1983;96(1):16-26.
  13. Jaffe GJ, Caprioli J. Optical coherence tomography to detect and man- age retinal disease and glaucoma. Am J Ophthalmol 2004;137(1):156- 69. Fabritius T, Makita S, Miura M, Myllylä R, Yasuno Y. Automated seg- mentation of the macula by optical coherence tomography. Opt Exp - ress 2009;17(18):15659-69.
  14. Lumbroso B, Rispoli M. Pratik OKT el kitabı. İstanbul: Hiper tıp, 2012:3-5.
  15. Sidman RL, Kosaras B, Tang M. Pigment epithelial and retinal phe- notypes in the vitiligo mivit, mutant mouse. Invest Ophthalmol Vis Sci 1996;37(6):1097-115.