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Journals / MN Oftalmoloji / 2020 / Cilt: 27 - Sayı: 1

Evaluation of Elabela, Apelin-13 and Nitric Oxide Levels in Serum and Aqueous Humor in Diabetic and Non-Diabetic Cataract Patients

Diyabetik Olan ve Olmayan Katarakt Hastalarında Fakoemülsifikasyon Sonrası Serum ve Hümör Aközde Elabela, Apelin-13 ve Nitrik Oksit Düzeylerinin Değerlendirilmesi

Yavuz ORUÇ
Suna AYDIN
Meltem YARDIM
Pages
44–48
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: In patients with diabetes mellitus, nitric oxide levels were found to be high in both aqueous humor and serum.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To compare the levels of elabela, apelin-13 and nitric oxide in aqueous humor and simultaneous venous blood serum in between diabetic patients with cataract and non-diabetic cataract patients.
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Key Findings & Data:Material and Method: The study was performed on 44 patients, including 22 patients who had diabetes mellitus and cataract in a single eye (DM+C) (n-22) and 22 patients without diabetes mellitus and had cataract at a single eye (C) (n=22), in whom phacoemulsification cataract surgery was performed.
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Conclusion & Impact:Conclusion: In patients with diabetes mellitus, nitric oxide levels were found to be high in both aqueous humor and serum.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: To compare the levels of elabela, apelin-13 and nitric oxide in aqueous humor and simultaneous venous blood serum in between diabetic patients with cataract and non-diabetic cataract patients. Material and Method: The study was performed on 44 patients, including 22 patients who had diabetes mellitus and cataract in a single eye (DM+C) (n-22) and 22 patients without diabetes mellitus and had cataract at a single eye (C) (n=22), in whom phacoemulsification cataract surgery was performed. Elabela, apelin and nitric oxide levels in serum and humor aqueous were measured by ELISA. Results: Only the nitric oxide level among these parameters measured in both humor aqueous and serum, was significantly higher in human aqueous of patient group with both diabetes and cataract (p<0.05). No statistically significant difference was found between the other parameters. Conclusion: In patients with diabetes mellitus, nitric oxide levels were found to be high in both aqueous humor and serum.

Özet

Amaç: Diabetes mellitus olan katarakt ve diyabetik olmayan katarakt hastaları arasında hümör aközde ve eş zamanlı venöz kan serumunda Elabela, Apelin-13 ve nitrik oksit düzeylerini karşılaştırmak. Gereç ve Yöntem: Çalışmaya fakoemülsifikasyon yöntemi ile katarakt cerrahisi uygulanan, tek gözde katarakt ve diabetes mellitus olan (Diabetes mellitus+C) n=22; tek gözde kataraktı olup, diabetes mellitusu olmayan (C) n=22; toplam 44 katılımcı dahil edildi. Serum ve hümör aközde elabela, apelin ve nitrik oksit düzeyleri ELISA yöntemiyle ölçüldü. Bulgular: Hem hümör aközde hem de serumda ölçülen parametrelerden sadece nitrik oksit düzeyi hümör aközde diyabetik katarakt grubunda istatistiksel olarak anlamlı bir şekilde yüksek idi (p<0,05). Diğer parametreler arasında istatistiksel olarak anlamlı bir fark bulunamadı. Sonuç: Diabetes mellituslu hastalarda hem aköz hömörde hem de serumda nitrik oksit düzeyleri yüksek tespit edilmiştir.

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Cite This Article

ORUÇ, Y., AYDIN, S., YARDIM, M. (2020). Evaluation of Elabela, Apelin-13 and Nitric Oxide Levels in Serum and Aqueous Humor in Diabetic and Non-Diabetic Cataract Patients. MN Oftalmoloji, Cilt: 27 - Sayı: 1, 44–48. https://ajindex.com/articles/295343

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