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Journals / Molecular Imaging and Radionuclide Therapy / 2013 / Cilt: 22 - Sayı: 3

Hepatik Arter Perfüzyon Sintigrafisindeki Perfüzyon Paterni ile Y-90 Mikrosfer Tedavisine Yanıt Arasındaki İlişki

The Relation Between Perfusion Pattern of Hepatic Artery Perfusion Scintigraphy and Response to Y-90 Microsphere Therapy

Bilge SALANCİ VOLKAN
MURAT FANİ BOZKURT
Bora PEYNİRCİOĞLU
Barbaros ÇİL
ÖMER UĞUR
Pages
98–102
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Perfusion pattern observed on hepatic artery perfusion scintigraphy may be a successful predictor of early response to radiomicrosphere therapy.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Hepatic artery perfusion scintigraphy is a routine procedure for patient evaluation before Y-90 radiomicrosphere therapy and mostly used for prediction of extrahepatic leakage.
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Key Findings & Data:Methods: A total of 99 radiomicrosphere therapy applications were carried out in 80 patients (M/F: 55/25).
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Conclusion & Impact:Conclusion: Perfusion pattern observed on hepatic artery perfusion scintigraphy may be a successful predictor of early response to radiomicrosphere therapy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Hepatic artery perfusion scintigraphy is a routine procedure for patient evaluation before Y-90 radiomicrosphere therapy and mostly used for prediction of extrahepatic leakage. Moreover, it also displays perfusion pattern of tumours, which is an important parameter on success of the therapy. The aim of this study is to assess the relation between the perfusion pattern on hepatic artery perfusion scintigraphy and radiomicrosphere therapy response. Methods: A total of 99 radiomicrosphere therapy applications were carried out in 80 patients (M/F: 55/25). Results: Heterogeneous and diffuse perfusion patterns were observed in 47 patients and 52 patients, respectively. The patients with diffuse perfusion pattern had better therapy response both on FDG PET/CT (p= 0.04) and CT (p=0.008) when compared to those with heterogenous perfusion pattern. Conclusion: Perfusion pattern observed on hepatic artery perfusion scintigraphy may be a successful predictor of early response to radiomicrosphere therapy.

Özet

Amaç: Hepatik arter perfüzyon sintigrafisi (HAPS) Y-90 mikroküre tedavisi öncesinde hastalarda ekstrahepatik kaçak saptanması için kullanılan rutin bir tetkiktir. Bu çalışmanın amacı HAPS perfüzyon paterni ile Y-90 mikrosfer tedavisine yanıt arasındaki ilişkinin araştırılmasıdır. Yöntemler: Toplam 80 hastaya (E/K: 55/25) yapılan 99 HAPS geriye dönük olarak değerlendirildi. HAPS perfüzyonu difüz ve heterojen olmak üzere gruplandı. Hastalara tedavi öncesinde ve sonrasında abdomen BT ve FDG PET/BT yapıldı. Tedavi yanıtı RECIST ve PERCIST kriterleri kullanılarak değerlendirildi. Bulgular: Heterojen ve diffüz perfüzyon paterni sırası ile 47 ve 52 uygulamada gözlendi. Diffüz perfüzyon paterni olan hastalarda hem BT (p= 0,008) hem de FDG PET/BT (p= 0,04) ile değerlendirmede daha iyi tedavi yanıtı gözlendi. Sonuç: HAPS perfüzyon paterni Y-90 mikrosfer tedavisine erken yanıt değerlendirmesinde kullanılabilir.

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Cite This Article

VOLKAN, B. S., BOZKURT, M. F., PEYNİRCİOĞLU, B., ÇİL, B., UĞUR, Ö. (2013). Hepatik Arter Perfüzyon Sintigrafisindeki Perfüzyon Paterni ile Y-90 Mikrosfer Tedavisine Yanıt Arasındaki İlişki. Molecular Imaging and Radionuclide Therapy, Cilt: 22 - Sayı: 3, 98–102. https://ajindex.com/articles/295296

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