Journals / Molecular Imaging and Radionuclide Therapy / 2012 / Cilt: 21 - Sayı: 2

Paratiroid adenomunda oktreotid tutulumu

Octreotide uptake in parathyroid adenoma

Pages
77–79
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Octreotide scintigraphy may be promising and indicate a possibility of using somatostatin analogues for the medical treatment of somatostatin receptor positive parathyroid tumors. (MIRT 2012;21:77-79)

📌 3 Key Takeaways

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Objective & Hypothesis:The patient with a history of bone pain and muscle weakness, was thought to have oncogenic osteomalacia as a result of biochemical investigations and directed to Nuclear Medicine Department for a whole-body bone scintigraphy and $^{111}l$n-octreotide scintigraphy.
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Key Findings & Data:There was no focal pathologic tracer uptake, but generalized marked increase in skeletal uptake on bone scintigraphy.
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Conclusion & Impact:Octreotide scintigraphy may be promising and indicate a possibility of using somatostatin analogues for the medical treatment of somatostatin receptor positive parathyroid tumors. (MIRT 2012;21:77-79)
🔬Design:Research Article
📍Scope:2012 Verileri
⚙️Variables:Domain Parameters

Abstract

The patient with a history of bone pain and muscle weakness, was thought to have oncogenic osteomalacia as a result of biochemical investigations and directed to Nuclear Medicine Department for a whole-body bone scintigraphy and $^{111}l$n-octreotide scintigraphy. There was no focal pathologic tracer uptake, but generalized marked increase in skeletal uptake on bone scintigraphy. Octreotide scintigraphy showed accumulation of octreotide in the region of the left lobe of the thyroid gland in the neck. Thereafter, parathyroid scintigraphy was performed with technetium-99m labeled metroxy-isobutyl-isonitryl $(^{99m}$Tc-MIB) and MIBI scan demonstrated radiotracer uptake at the same location with octreotide scintigraphy. The patient underwent left inferior parathyroidectomy and histopathology confirmed a parathyroid adenoma. Somatostatin receptor positive parathyroid adenoma may show octreotide uptake. Octreotide scintigraphy may be promising and indicate a possibility of using somatostatin analogues for the medical treatment of somatostatin receptor positive parathyroid tumors. (MIRT 2012;21:77-79)

Özet

Yaygın kemik ve kas ağrıları nedeniyle başvuran ve yapılan biyokimyasal incelemeler sonucunda onkojenik osteomalazi düşünülen hasta, kemik ve $^{111}l$n-oktreotid sintigrafisi çekilmek üzere kliniğimize yönlendirildi. Kemik sintigrafisinde patolojik fokal bir odak gözlenmemekle birlikte iskelet sisteminde yaygın artmış aktivite tutulumu vardı. Oktreotid sintigrafisinde ise sol tiroid lojuna uyan alanda fokal artmış aktivite tutulumu gözlenmekteydi. Bunun üzerine yapılan paratiroid sintigrafisinde de, oktreotid sintigrafisindeki ile aynı lokalizasyonda, sol tiroid lobu inferior kesimine uyan alanda paratiroid adenomu ile uyumlu fokal artmış aktivite tutulumu izlendi. Daha sonra hastaya paratiroidektomi operasyonu yapıldı ve histopatolojik olarak paratiroid adenomu varlığı doğrulandı. Somatostatin reseptörü taşıyan paratiroid tümörleri oktreotid tutulumu gösterebilirler. Bu tümörlerin medikal tedavilerinde oktreotid sintigrafisi ile somatostatin analoglarının kullanılabilirliği öngörülebilir.(MIRT 2012;21:77-79)

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Cite This Article

KARAÇAVUŞ, S., KULA, M., KARACA, Z. C., ÜNLÜHIZARCI, K., TUTUŞ, A., BAYRAM, F., ÇOBAN, G. (2012). Paratiroid adenomunda oktreotid tutulumu. Molecular Imaging and Radionuclide Therapy, Cilt: 21 - Sayı: 2, 77–79. https://ajindex.com/articles/295269

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