Journals / Molecular Imaging and Radionuclide Therapy / 2012 / Cilt: 21 - Sayı: 2

Nonfonksiyone/hipofonksiyone böbreğe eşlik eden böbrekte görülen adaptif fonksiyonel farklılıkların kamera bazlı Tc 99m MAG3 klirensi ölçüm yöntemi ile gösterilmesi

Demonstration of adaptive functional differences seen in kidneys accompanying a nonfunctioning/hypofunctioning partner, using camera based Tc 99m MAG3 clearance measurement technique

Pages
56–62
DOI
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Camera based Tc 99m MAG3 clearance measurement is an objective method to demonstrate compensatory differences in renal function seen between kidneys with contralateral normofunctioning, hypofunctioning and nonfunctioning partner. (MIRT 2012;21:56-62)

📌 3 Key Takeaways

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Objective & Hypothesis:with total or partial loss of renal functioning mass, using camera-based Tc 99m MAG3 clearance technique.
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Key Findings & Data:Material and Methods: Eighty five patients (43M, 42F, age: 44.8±12.6, range: 18-77 years) with normal serum creatinine levels and normal (<Grade 1) Tc 99m MAG3 renogram curves were enrolled for this retrospective study.
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Conclusion & Impact:Camera based Tc 99m MAG3 clearance measurement is an objective method to demonstrate compensatory differences in renal function seen between kidneys with contralateral normofunctioning, hypofunctioning and nonfunctioning partner. (MIRT 2012;21:56-62)
🔬Design:Research Article
📍Scope:2012 Verileri
⚙️Variables:Domain Parameters

Abstract

with total or partial loss of renal functioning mass, using camera-based Tc 99m MAG3 clearance technique. Material and Methods: Eighty five patients (43M, 42F, age: 44.8±12.6, range: 18-77 years) with normal serum creatinine levels and normal (<Grade 1) Tc 99m MAG3 renogram curves were enrolled for this retrospective study. Patients were grouped as having; group 1: solitary normal kidney (unilateral atrophied/agenetic) (n=23), group 2: normal kidney with contralateral hypoplasic/hypofunctioning kidney (split renal function<30%), (n=24), group 3: bilateral normal kidneys (n=38). The measured camera based Tc 99m MAG3 clearances of normal kidneys in each group were compared. Results: Total Tc 99m MAG3 clearances (mL/min/1.73m2) were significantly lower in group 1 and group 2 compared to group 3 (281.5±46, 260.5±61.7 and 316.1±84, respectively). Highest isolated Tc 99m MAG3 clearances among normal functioning kidneys were observed in group 1 (281.5±45.6) followed by group 2 (204.4±55) and group 3 (157.5±44). Moderate negative correlation was detected between the Tc99m MAG3 clearances of normal kidneys and contralateral renal function (r=-0.5, p<0.001). Conclusion: Normal kidneys can compensate for the loss of contralateral kidney function via increasing their clearances, which seems to be dependent on the residual function of their partner. Camera based Tc 99m MAG3 clearance measurement is an objective method to demonstrate compensatory differences in renal function seen between kidneys with contralateral normofunctioning, hypofunctioning and nonfunctioning partner. (MIRT 2012;21:56-62)

Özet

Amaç: Çalışmamızın amacı, kısmi ya da tam fonksiyon kaybı olan bir böbreğe eşlik eden sağlam böbrekte oluşan fonksiyonel kompensatuar değişikliklerin gamma kamera Tc 99m MAG3 klirens ölçüm tekniği ile gösterilmesidir. Gereç ve Yöntemler: Bu retrospektif çalışmaya, Tc 99m MAG3 ile dinamik renal sintigrafi yapılan, serum kreatinin değeri ve renogram eğrisi normal olan (< grade 1) 85 hasta (43 Erkek, 42 kadın, yaş: 44,8±12,6) alındı. Hastalar; grup 1: tek taraflı normal böbrek (diğer böbrek atrofik/agenetik) (n=23), grup 2: normal böbrek ile karşı tarafta hipofonksiyone böbrek (split renal fonksiyon <%30), (n=24), group 3: bilateral normal böbrek (n=38) olarak gruplandırıldı. Her gruptaki normal renogram eğrisi olan sağlam böbreğin gamma kamera yöntemi ile ölçülen Tc 99m MAG3 klirensleri karşılaştırıldı. Bulgular: Total Tc 99m MAG3 klirensleri (mL/min/1.73m2) Grup1 ve grup2 de grup3’e kıyasla belirgin düşüktü (sırasıyla, 281,5±46, 260,5±61,7, 316,1±84). Ancak normal böbrekler arasında en yüksek klirens değeri grup 1’de gözlendi (281,5±45,6). Bunu grup 2: 204,4±55 ve grup 3:157,5±44 izledi. Normal böbrek klirensi ile kontralateral renal fonksiyon arasında negative korelasyon gözlendi (r=-0.5, p<0.001). Sonuç: Normal fonksiyon gören böbrekler karşı taraftaki böbreğin fonksiyon kaybını, kendi klirenslerini, diğer böbreğin rezidü fonksiyonsiyonu ile orantılı olarak artırmak yoluyla kompanse edebilirler. Gamma kamera ile Tc 99m MAG3 klirensi ölçümü, hipofonksiyone, nonfonksiyone ve normofonksiyone böbreklere eşlik eden, normal fonksiyon gören böbrekler arasındaki kompensasyonel fonksiyonel farkın gösterilmesinde objektif bir yöntemdir. (MIRT 2012;21:56-62)

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Cite This Article

AKKAŞ, B. E., VURAL, G. U., AKDEMİR, Ü. Ö., KARABACAK, N. I. (2012). Nonfonksiyone/hipofonksiyone böbreğe eşlik eden böbrekte görülen adaptif fonksiyonel farklılıkların kamera bazlı Tc 99m MAG3 klirensi ölçüm yöntemi ile gösterilmesi. Molecular Imaging and Radionuclide Therapy, Cilt: 21 - Sayı: 2, 56–62. https://ajindex.com/articles/295224

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