Journals / Molecular Imaging and Radionuclide Therapy / 2011 / Cilt: 20 - Sayı: 3

Meme kanserinde lenfosintigrafi ve intraoperatif gama prob ile sentinel lenf nodu saptanmasında eksizyonel biyopsinin etkisi

The effect of the excisional biopsy in the detection of the sentinel lymph node by lymphoscintigraphy and intraoperative gamma probe in breast cancer

Pages
100–103
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: According to results of our study the excisional biopsy was not the only factor but also other factors such as breast mass, calcified or metastatic lymph node may be affected the success rate of the SLN. (MIRT 2011;20:100-103)

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Sentinel lymph node (SLN) scintigraphy is used widespread in breast cancer, but the effect of the radionuclide agent, injection technique, the method of biopsy, tumor localization, breast size remain controversial.
📊
Key Findings & Data:We examined the effects of the excisional biopsy in the rate of the SLN identification with lymphoscintigraphy (LS) and intraoperative gamma probe (IGP).
💡
Conclusion & Impact:Conclusion: According to results of our study the excisional biopsy was not the only factor but also other factors such as breast mass, calcified or metastatic lymph node may be affected the success rate of the SLN. (MIRT 2011;20:100-103)
🔬Design:Research Article
📍Scope:2011 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Sentinel lymph node (SLN) scintigraphy is used widespread in breast cancer, but the effect of the radionuclide agent, injection technique, the method of biopsy, tumor localization, breast size remain controversial. We examined the effects of the excisional biopsy in the rate of the SLN identification with lymphoscintigraphy (LS) and intraoperative gamma probe (IGP). Material and Methods: One hundred patients (age range: 28-79 yr) with breast cancer were included in the study. They consisted of two groups: Group 1; there were 58 patients without excisional biopsy. Group 2; there were 42 patients with excisional biopsy. LS: 2 hours before the operation, 37 MBq/ ml Tc 99m colloidal rhenium sulphide was injected at the periaerolar region intradermally. Anterior and lateral static images were acquired. IGP: The hot spot of greatest radioactivity were marked on the skin during the surgery with IGP and removed. Excised SLNs were examined with frozen section. After that histopathological and immunohistochemical examinations were performed. Results: SLNs were found in all patients in group 1 (100%), in 39 patients of group 2 (93%) with LS. SLNs were excised in 57 of the 58 patients of group 1 (98%), in 38 of the 42 patients of group 2 (90%) with IGP. Metastases were found in SLNs in 27 patients (28%). Axillary dissection was performed in these patients. Conclusion: According to results of our study the excisional biopsy was not the only factor but also other factors such as breast mass, calcified or metastatic lymph node may be affected the success rate of the SLN. (MIRT 2011;20:100-103)

Özet

Amaç: Sentinel lenf nodu (SLN) sintigrafisi meme kanserinde yaygın olarak kullanılmaktadır.Fakat radyonüklid ajanın, enjeksiyon tekniğinin, biyopsi metodunun, tümör lokalizasyonunun ve meme boyutunun etkileri tartışmalıdır. Bu çalışmada eksizyonel biyopsinin SLN’nun lenfosintigrafi (LS) ve intraoperatif gama prob (IGP) ile saptanma oranına etkisini araştırdık. Gereç ve Yöntemler: Meme kanserli yüz hasta (yaş aralığı: 28-79 yıl) çalışmaya alındı. İki gruba ayrıldı: Grup 1; Eksizyonel biyopsi olmayan 58 hasta vardı. Grup 2; Eksizyonel biyopsi olan 42 hasta vardı. (LS): Operasyondan 2 saat önce, 37 MBq/1ml Tc 99m renyum sülfid kolloid intradermal olarak periareolar bölgeye enjekte edildi. Anterior ve lateral statik görüntüler alındı. (IGP): Cerrahi sırasında IGP ile en sıcak nokta deri üzerine işaretlendi ve çıkarıldı. Çıkarılan SLN’ları frozen kesitleri ile incelendi. Daha sonra histopatolojik ve immünohistokimyasal inceleme yapıldı. Bulgular: LS ile SLN’ları Grup 1’deki tüm hastalarda (%100), grup 2’deki 39 hastada (%93) bulundu. IGP ile SLN’ları Grup 1’deki 58 hastanın 57’sinde (%98), Grup 2’deki 42 hastanın 38’inde (%90) çıkarıldı. SLN’larında metastaz 27 hastada bulundu (%28). Bu hastalara aksiller diseksiyon yapıldı. Sonuç: Çalışmamızın sonuçlarına göre eksizyonel biyopsi, radyofarmasötik periareolar enjeksiyon yöntemi ile yapılırsa, SLN saptanma oranını etkileyen faktör değildir. (MIRT 2011;20:100-103)

🔖

Cite This Article

ARICAN, P., PEKSOY, İ., NALDÖKEN, S., BOZKURT, B. (2011). Meme kanserinde lenfosintigrafi ve intraoperatif gama prob ile sentinel lenf nodu saptanmasında eksizyonel biyopsinin etkisi. Molecular Imaging and Radionuclide Therapy, Cilt: 20 - Sayı: 3, 100–103. https://ajindex.com/articles/295203

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Halsted WS. The results of operations for the cure of cancer the breast performed at the John Hopkins Hospital from June 1989 to January 1994, John Hopkins Hospital Hosp Bull. 1994- 1995:4:297-323
  2. Haris JR, Hellman S. Natural history of breast cancer. In: Haris JR, Lippman ME, Morrow M, et.al, eds. Diseases of the Breast. Philadelphia: Lippincott-Raven:1996
  3. Cascinelli N, Greco M, Bufalino R, Clemente C, Galluzzo D, Delle Done V, de Lellis R, Sacchini V, Veronesi U. Prognosis of breast cancer with axillary node metastasis after surgical treatment only. Eur J Cancer Clin Oncol 1987;23:795-799
  4. Siegel BM, Mayzel KA, Love Sm. Level 1 and 2 axillary dissection in the treatment of early stage breast cancer. An analysis of 259 consecutive patients. Arch Surg 1990;125:1144-1147
  5. Maunsell E, Brisson J, Deschenes L. Arm problems and psychological distress after surgery for breast cancer. Can J Surg 1993;36:315-320
  6. Warmuth MA, Bowen G, Prosnitz LR, Chu L, Broadwater G, Peterson B, Leight D, Winer EP. Complications of axillary lymph node dissection for carcinoma of the breast. Cancer 1998;83:1362-1368
  7. Dixon M. Sentinel node biopsy in breast cancer. A promising technique, but it should not be introduced without proper trials. BMJ 1998;317(7145):295-296
  8. De Cicco D, Cremonesi M, Luini A, Bartolomei M, Grana C, Prisco G, Galimberti V, Calza P, Viale G, Veronesi U, Paganelli G. Lymphoscintigraphy and radioguided biopsy of the sentinel axillary node in breast cancer. J Nucl Med 1998;39:2080-2084
  9. Borgstein PJ, Meijer S, Pijpers R. Intradermal blue dye to identify sentinel lymph node in breast cancer. Lancet 1997;349:1668-1669
  10. Uren RF, Howman-Gilers RB, Thompson JF. Malouf D, Ramsey- Stewart G, Niesche FW, Renwick SB. Mammary lymphoscintigraphy in breast cancer. J Nucl Med 1995;36:1775-1780
  11. Ege GN. Lymphoscintigraphy, techniques and application in the management of breast cancer. Semin Nucl Med 1983;13:26-34
  12. Kaptejin BA, Nieweg OE, Petersen JL, Rutgers EJ, Hart AA, Van Dongen JA, Kroon BB. Identification and biopsy of the sentinel node in breast cancer. Eur J Surg Oncol 1998;24:427-430
  13. Krag DN, Weaver DL, Alex JC, Fairbank JT. Surgical resection and radiolocalization of sentinel lymph node in breast cancer using a gamma probe. Surg Oncol 1993;2:335-339
  14. Borgstein PJ, Pijpers R, Comans EF, Van Diest PJ, Boom RP, Meijer S. Sentinel Lymph node in breast cancer: guidelines and pitfalls of lymphoscintigraphy and gamma probe