Journals / Molecular Imaging and Radionuclide Therapy / 2011 / Cilt: 20 - Sayı: 3

Gastrik lenfoma tanılı olguda yeniden evreleme FDG PET/BT görüntülemede kolonda metformin kullanımına sekonder yoğun FDG tutulumu

Metformin-induced intense bowel uptake observed on restaging FDG PET/CT study in a patient with gastric lymphoma

Pages
114–116
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Recognizing physiologic bowel activity is crucial for the accuracy of PET image interpretation. (MIRT 2011;20:114-116)

📌 3 Key Takeaways

🎯
Objective & Hypothesis:A 53-year-old man with a diagnosis of gastric non-Hodgkin lymphoma (NHL) underwent PET/CT scans both prior to starting chemotherapy and immediately following completion of chemotherapy to evaluate the response to therapy.
📊
Key Findings & Data:Post-therapy PET/CT study performed after 6 courses of chemotherapy showed complete resolution of the disease with no evidence of residual FDG uptake.
💡
Conclusion & Impact:Recognizing physiologic bowel activity is crucial for the accuracy of PET image interpretation. (MIRT 2011;20:114-116)
🔬Design:Research Article
📍Scope:2011 Verileri
⚙️Variables:Domain Parameters

Abstract

A 53-year-old man with a diagnosis of gastric non-Hodgkin lymphoma (NHL) underwent PET/CT scans both prior to starting chemotherapy and immediately following completion of chemotherapy to evaluate the response to therapy. Pre-therapy PET/CT images showed intense FDG uptake in the antral region of the stomach. Biodistribution of FDG was otherwise unremarkable. The patient was started on metformin in the middle of his therapy period to provide glycemic control. Post-therapy PET/CT study performed after 6 courses of chemotherapy showed complete resolution of the disease with no evidence of residual FDG uptake. However, intense and diffuse FDG accumulation is observed in the bowel, which was interpreted as physiological and most probably due to metformin administration. It should be borne in mind that there are a number of physiological variants of FDG biodistribution seen on PET/CT imaging. Recognizing physiologic bowel activity is crucial for the accuracy of PET image interpretation. (MIRT 2011;20:114-116)

Özet

Elli üç yaşında mide NHL tanılı erkek hastaya tedaviye yanıtı değerlendirmek amacıyla tedavi öncesi ve sonrasında PET/BT görüntülemesi yapıldı. Tedavi öncesi PET/BT görüntülerinde mide antrumunda yoğun FDG tutulumu izlendi. İnceleme alanına giren diğer vücut bölümlerinde patolojik FDG tutulum odağı saptanmadı. Altı kür kemoterapi tedavisinin ortasında kan şekeri kontrolünü sağlamak amacıyla metformin başlanan hastanın tedavi sonrası PET/BT görüntülerinde tam metabolik yanıt görüldü. Ancak barsaklarda yoğun ve diffüz FDG tutulumu izlendi. Bu görünüm metformin kullanımına bağlı fizyolojik uptake olarak değerlendirildi. PET/CT görüntülemede fizyolojik barsak aktivitesini tanımak PET imajlarını yorumlamadaki doğruluğu arttırmaktadır. (MIRT 2011;20:114-116)

🔖

Cite This Article

YILMAZ, S., ÖZHAN, M., SAĞER, M. S., ATİK, D. Y., HALAÇ, M., SÖNMEZOĞLU, K. (2011). Gastrik lenfoma tanılı olguda yeniden evreleme FDG PET/BT görüntülemede kolonda metformin kullanımına sekonder yoğun FDG tutulumu. Molecular Imaging and Radionuclide Therapy, Cilt: 20 - Sayı: 3, 114–116. https://ajindex.com/articles/295194

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (1)

  1. Bybel B, Greenberg ID, Paterson J, Ducharme J, Leslie WD. Increased F-18 FDG intestinal uptake in diabetic patients on metformin: a matched case-control analysis. Clin Nucl Med. 2011;36:452-426 2. Shammas A, Lim R, Charron M. Pediatric FDG PET/CT: physiologic uptake, normal variants, and benign conditions. Radiographics. 2009;29:1467-1486. 3. Bailey CJ. Metformin--an update. Gen Pharmacol. 1993;24:1299-309. 4. Gontier E, Fourme E, Wartski M, Blondet C, Bonardel G, Le Stanc E, Mantzarides M, Foehrenbach H, Pecking AP, Alberini JL. High and typical 18F-FDG bowel uptake in patients treated with metformin. Eur J Nucl Med Mol Imaging 2008;35: 95-99. 5. Penicaud L, Hitier Y, Ferre P, Girard J. Hypoglycemic effect of metformin in genetically obese (fa/fa) rats results from an increased utilization of blood glucose by intestine. Biochem J 1989;262: 881-885. 6. Walker J, Jijon HB, Diaz H, Salehi P, Churchill T, Madsen KL. 5-aminoimidazole- 4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK. Biochem J 2005;385: 485-491. 7. Kamel EM, Thumshirn M, Truninger K, Schiesser M, Fried M, Padberg B, Schneiter D, Stoeckli SJ, von Schulthess GK, Stumpe KD. Significance of incidental 18F-FDG accumulations in the gastrointestinal tract in PET/CT: correlation with endoscopic and histopathologic results. J Nucl Med. 2004;45(11):1804-1810.