AI Summary & Key Takeaways
AI InsightConclusion: Our results demonstrate that FDG PET/CT seems to have considerable contribution to reveal the reason of undiagnosed patients with FUO investigated by conventional diagnostic methods, clinical and laboratory observations. (MIRT 2011; 20: 19-25)
📌 3 Key Takeaways
Abstract
Objective: Fever of unknown origin (FUO) is a challenge for the physician and needs use of clinical, laboratory, and imaging studies and also invasive and/or non-invasive interventions to detect the etiology. The aim of present study was to assess the role of FDG PET/CT in determining the etiology in patients with FUO. Material and Methods: Twenty-four patients (median age 52, range 5-77 years, 6 female, 18 male) who were diagnosed with FUO were retrospectively analyzed in this study. Before the FDG PET/CT studies, none of them had a definitive reason for their diseases investigated by conventional radiological or scintigraphic methods, clinical and laboratory observations. Results: The positive result was achieved in 19 (79.2%) of 24 patients as findings of the FDG PET/CT. However, FDG PET/CT was useful for definitive diagnosis in 12 (63.2%) of 19 positive patients. Malignant diseases were determined to be the underlying cause of FUO in 5 (41.6%) of 12 patients. Noninfectious inflammatory causes were detected in 2 (16.7%) patients, infections were exhibited in 3 (25%) patients, and miscellaneous diseases demonstrated in 2 (16.7%) patients. In 7 patients the detected pathological uptakes on FDG PET/CT were not helpful for the definitive diagnosis. In remaining 5 patients who showed no pathological uptake in the FDG PET/CT, diagnosis could not be established by other methods, as well. The sensitivity, specificity, and positive and negative predictive values for the determination of FUO etiology were 92.3%, 45.4%, 63.1%, and 100% for FDG PET/CT. Conclusion: Our results demonstrate that FDG PET/CT seems to have considerable contribution to reveal the reason of undiagnosed patients with FUO investigated by conventional diagnostic methods, clinical and laboratory observations. (MIRT 2011; 20: 19-25)
Özet
Amaç: Nedeni bilinmeyen ateş (NBA) klinisyenler için halen tanımlanması zor bir hastalık olup klinik, laboratuvar ve görüntüleme tekniklerinin yanında birçok invaziv ve noninvaziv girişimlere gerek duyulan bir durumdur. Bu çalışmanın amacı, NBA etyolojisini saptamada FDG PET/BT'nin yerini saptamaktı. Gereç ve Yöntemler: FUO tanısı almış 24 hasta (ortalama yaş 52, 5-77 aralığında, 6 kadın, 18 erkek) retrospektif olarak incelendi Bulgular: Yirmi dört hastadan 19'unda (%79.2) FDG PET/BT bulguları pozitif bulundu. Bu 19 hastadan 12'sinde (63.2) FDG PET/ BT tanıya yardımcı oldu. NBA etyolojisinde 12 hastadan 5'inde (%41.6) malignite saptandı. Noninfeksiyoz enşamatuar nedenler 2 hastada (16.7) tespit edilirken, 3 hastada (%25) enfeksiyon, 2 hastada (%16.7) az rastlanan nedenler saptandı. Yedi hastada FDG PET/BT'de saptanan patolojik tutulumlar tanıya yardımcı olmadı. Patolojik tutulum görülmeyen 5 hastada diğer tanı yöntemleriyle de bir tanıya ulaşılamadı. FDG PET/BT'nin NBA etyolojisini saptamadaki sensitivite, spesifite, pozitif ve negatif prediktif değerleri %92.3, %45.4, %63.1, ve %100 bulundu. Sonuç: Bu çalışmada FDG PET/BT'nin diğer tanı yöntemleriyle tanı alamayan NBA olgularında etyolojiyi saptamada faydalı bir yöntem olduğu gösterilmiştir. (MIRT 2011; 20: 19-25)