Journals / Nöropsikiyatri Arşivi / 2015 / Cilt: 52 - Sayı: 1

Cortical Excitability and Agressive Behavior in Post-Traumatic Stress Disorder

Travma Sonrası Stres Bozukluğunda Kortikal Eksitabilite ve Saldırgan Davranış

Pages
73–77
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: We concluded that there was an increase in cortical excitabi-lity in PTSD patients and we suggest that this increase might be associated with hyperarousal symptoms and aggressive behavior.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Hyperarousal and alertness play an important role in the clinical presentation of Post-traumatic stress disorder (PTSD).
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Key Findings & Data:Methods: The study included 37 patients with a diagnosis of PTSD according to DSM-IV criteria and 25 healthy volunteers.
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Conclusion & Impact:Conclusion: We concluded that there was an increase in cortical excitabi-lity in PTSD patients and we suggest that this increase might be associated with hyperarousal symptoms and aggressive behavior.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Hyperarousal and alertness play an important role in the clinical presentation of Post-traumatic stress disorder (PTSD). Strenuous effort has been made to shed light on the mechanisms that cause these symptoms of patients. Based on the claim that there is a relationship between some subtypes of hyperarousal symptoms and aggression in patients with PTSD, we aimed to examine the relationship between electrophysiological measurements that was measured through transcranial magnetic stimulation (TMS) and aggression scale scores of PTSD patients in this study. Methods: The study included 37 patients with a diagnosis of PTSD according to DSM-IV criteria and 25 healthy volunteers. Electrophysiological measurements of participants were made with TMS. The Buss Perry Aggression Questionnaires was administered to patients and control group Results: In the patient group, a positive correlation was found between scores of aggression and arousal symptoms. Motor excitability threshold, one of TMS measurements, which is a sign of cortical excitability, was significantly lower in the patient group than the control group. There was a negative correlation between aggression scale scores and the parame-ters of motor excitability threshold and cortical silent period which both shows cortical excitability of the patients. Conclusion: We concluded that there was an increase in cortical excitabi-lity in PTSD patients and we suggest that this increase might be associated with hyperarousal symptoms and aggressive behavior.

Özet

Amaç: Travma sonrası stres bozukluğunun (TSSB) klinik görünümünde kolay uyarılma ve tetikte olma hali önemli bir yer tutar. Hastalarda bu klinik görünümün oluşmasına neden olan mekanizmaların aydınlatılmasına çalışılmaktadır. Bu çalışmada, aşırı uyarılmışlık belirtilerinin bazı alt belirtileri ile saldırganlık arasında ilişki olduğu düşüncesinden yola çıkarak TSSB hastalarındaki saldırganlık ölçeği puanları ile transkranial manyetik stimülasyon (TMS) aracılığıyla ölçülen elektrofizyolojik ölçümler arasındaki ilişkiyi incelemeyi amaçladık Yöntem: Çalışmaya, DSM-IV'e göre TSSB tanısı konan 37 hasta ile 25 sağlıklı gönüllü alınmıştır. Katılımcıların elektrofizyolojik ölçümleri TMS ile yapılmıştır. Hastalara ve kontrol grubuna Buss Perry Saldırganlık Ölçeği uygulanmıştır. Bulgular: Hastalardaki saldırganlık ölçeği puanları ile uyarılmışlık belirtileri arasında pozitif bir ilişkili bulunmuştur. TMS ölçümlerinden kortikal eksita-bilitenin (uyarılabilirliğinin) bir bulgusu olan motor uyarılma eşiği kontrol grubuna oranla hasta grubunda anlamlı düzeyde düşük bulunmuştur. Has-taların kortikal uyarılabilirliğini gösteren parametreler olan motor uyarılma eşiği ve kortikal sessiz periyot ile saldırganlık ölçek puanları arasında negatif ilişki bulunmuştur.Sonuç: Travma sonrası stres bozukluğu hastalarında kortikal uyarılabilirlik-te bir artış olduğu ve bu artışın uyarılmışlık belirtileri ve saldırganlık davra-nışları ile dolaylı olarak ilişkili olabileceği sonucuna varılmıştır

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Cite This Article

BOLU, A., BALIKÇI, A., ERDEM, M., ÖZNUR, T., ÇELİK, C., UZUN, Ö. (2015). Cortical Excitability and Agressive Behavior in Post-Traumatic Stress Disorder. Nöropsikiyatri Arşivi, Cilt: 52 - Sayı: 1, 73–77. https://ajindex.com/articles/294399

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