Journals / Ondokuz Mayıs Üniversitesi Tıp Dergisi (. Journal of Experimental and Clinical Medicine) / 1999 / Cilt: 16 - Sayı: 3

Sepsisli yenidoğanlarda tiroid fonksiyonları

Thyroid functions in newborns with septicemia

Pages
224–228
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

A positive correlation between low TT<sub>3</sub> and TT<sub>4</sub> levels on 'the tenth day and mortality rate was also shown.

📌 3 Key Takeaways

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Objective & Hypothesis:To investigate the alternations in thyroid functions the concentrations of total triiodothyronine (TT<sub>3</sub>), total tyroxine (TT<sub>4</sub>), free triiodothyronine (FT<sub>3</sub>), free tyroxine (FT<sub>4</sub>), tyroxine binding globulin (TBG), albumin and tyroxine binding prealbumine (TBPA) were measured in 32 newborns with septicemia on days 1, 5 and 10 of hospitalisation and compared with age-matched controls.
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Key Findings & Data:FT<sub>3</sub> and FT4 levels of patients were significantly lower on the first day but returned to normal on the fifth and tenth days.
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Conclusion & Impact:A positive correlation between low TT<sub>3</sub> and TT<sub>4</sub> levels on 'the tenth day and mortality rate was also shown.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Tiroid fonksiyon testleri · Septisemi · Süt çocuğu

Abstract

To investigate the alternations in thyroid functions the concentrations of total triiodothyronine (TT<sub>3</sub>), total tyroxine (TT<sub>4</sub>), free triiodothyronine (FT<sub>3</sub>), free tyroxine (FT<sub>4</sub>), tyroxine binding globulin (TBG), albumin and tyroxine binding prealbumine (TBPA) were measured in 32 newborns with septicemia on days 1, 5 and 10 of hospitalisation and compared with age-matched controls. FT<sub>3</sub> and FT4 levels of patients were significantly lower on the first day but returned to normal on the fifth and tenth days. On contrary to this TT<sub>3</sub> and TT<sub>4</sub> levels were lower on all three occasions but no significant changes were observed in TSH concentrations. TBPA and albumin levels were significantly lower in patients on the first and fifth days. A positive correlation between low TT<sub>3</sub> and TT<sub>4</sub> levels on 'the tenth day and mortality rate was also shown.

Özet

Yenidoğan sepsisinde tiroid fonksiyonlarındaki değişiklikleri araştırmak amacı ile sepsisli 32 yenidoğanda hastaneye yatışlarının 1..,..5., ve 10.günlerinde serum total T 4 , total T 3 , serbest T 3 , serbest T 4 , tiroksin bağlayan globulin ve tiroksin bağlayan prealbumin konsantrasyonları ölçüldü ve sonuçlar benzer yaşlardaki kontrol grubu ile karşılaştırıldı. Birinci günde hastaların serum serbest T 3 ve serbest T 4 seviyeleri anlamlı derecede düşük idi fakat 5. ve 10. günlerde değerler normale döndü. Buna karşın total T 3 ve T 4 değerleri üç ölçümde de düşük seviyelerde saptandı ve TSH düzeyi her zaman normal sınırlarda kaldı. Tiroksin bağlayan prealbumin ve albumin değerleri 1. ve 5. günlerde düşük idi. Onuncu günde düşük total T 4 ve total T 3 değerleri ile mortalite arasında pozitif bir ilişki olduğu görüldü.

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Cite This Article

ÖZTÜRK, F., ÇETİNKAYA, F., YILMAZER, F., AYDIN, M., GÜRSES, N. (1999). Sepsisli yenidoğanlarda tiroid fonksiyonları. Ondokuz Mayıs Üniversitesi Tıp Dergisi (. Journal of Experimental and Clinical Medicine), Cilt: 16 - Sayı: 3, 224–228. https://ajindex.com/articles/293395