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Journals / Nöropsikiyatri Arşivi / 2017 / Cilt: 54 - Sayı: 3

Düşük Serum UCH-L1 ve TDP-43 Düzeyleri Otizmde Bozulmuş Ubikuinasyon Sürecini Yansıtabilir mi?

Do Low Serum UCH-L1 and TDP-43 Levels Indicate Disturbed Ubiquitin- Proteosome System in Autism Spectrum Disorder?

İHSAN ÇETİN
İhsan TEZDİĞ
Mahmut Cem TARAKÇIOĞLU
MUHAMMED TAYYİB KADAK
ÖMER FARUK DEMİREL
ÖMER FARUK ÖZER
FIRAT ERDOĞAN
Burak DOĞANGÜN
Pages
267–271
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Low serum levels of UCH-L1 and TDP-43 may reflect disturbed ubiquitination in autism

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: The mechanism of ubiquitination-related abnormalities causing neural development problems is still unclear.
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Key Findings & Data:We examined the association between autism and serum transactive response DNAbinding protein-43 (TDP-43) and ubiquitin c-terminal hydrolase-L1 (UCH-L1) levels, both of which are members of the ubiquitinproteosome system.Methods: We measured serum levels of TDP-43 and UCH-L1 in 24 children with autism and 24 healthy children.
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Conclusion & Impact:Conclusion: Low serum levels of UCH-L1 and TDP-43 may reflect disturbed ubiquitination in autism
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: The mechanism of ubiquitination-related abnormalities causing neural development problems is still unclear. We examined the association between autism and serum transactive response DNAbinding protein-43 (TDP-43) and ubiquitin c-terminal hydrolase-L1 (UCH-L1) levels, both of which are members of the ubiquitinproteosome system.Methods: We measured serum levels of TDP-43 and UCH-L1 in 24 children with autism and 24 healthy children. Childhood Autism Rating Scale (CARS) was used to assess symptom severity at admission. Results: The mean serum TDP-43 and UCH-L1 levels in children with autism spectrum disorder (ASD) were found to decrease compared to healthy controls (p<0.001, 506.21±780.97 ng/L and 1245.80±996.76 ng/L, respectively; 3.08±5.44 ng/mL and 8.64±6.67 ng/mL, respectively). A positive correlation between serum TDP-43 levels and UCH-L1 levels was found in the ASD group (r=0.947, n=24, p<0.001). The CARS score of children with ASD was 48.91 points (standard deviation [SD]: 5.82). Conclusion: Low serum levels of UCH-L1 and TDP-43 may reflect disturbed ubiquitination in autism

Özet

Amaç: Protein ubikitinlenme ile ilgili bozuklukların nöronal gelişim sorunlarına nasıl yol açtığı açıklanamamıştır. Bu çalışmada, ubikuitin proteozom sistemine üye olan ubikuitin c-terminal hidrolaz-L1 (UCH-L1) ve transaktif yanıtlı DNA-bağlayıcı protein (TDP-43) düzylerinin otizm ile ilişkisi araştırılmıştır.Yöntemler: Bu bağlamda 24 otizm tanılı çocuk ve 24 sağlıklı çocukta serum TDP-43 ve UCH-L1 düzeylerine bakılmıştır. Otizm şiddet derecesi Çocukluk Otizm Derecelendirme Ölçeği (ÇODÖ) ile değerlendirilmiştir. Bulgular: Otizm tanılı çocukların başvuru sırasında ortalama ÇODÖ puanları 48.91 (SD: 5.82) idi. Sağlıklı gruba göre otizmli grupta serum TDP-43 ve Serum UCH-L1 düzeyleri anlamlı olarak düşüktü (sırasıyla 506,21±780,97 ng/L ve 1245,80±996,76 ng/L; 3,08±5,44 ng/mL ve 8,64±6,67 ng/mL; p<0.001). Serum TDP-43 and UCH-L1 düzeyleri arasında pozitif korelasyon anlamlı olarak tespit edildi (r=0.947, n= 24, p<0.001). Sonuç: Sonuç olarak, düşük UCHL-L1 ve TDP-43 düzeylerinin, otizmde bozulmuş ubikitinlenme sürecini yansıtabileceği düşünülmüştür.

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Cite This Article

ÇETİN, İ., TEZDİĞ, İ., TARAKÇIOĞLU, M. C., KADAK, M. T., DEMİREL, Ö. F., ÖZER, Ö. F., ERDOĞAN, F., DOĞANGÜN, B. (2017). Düşük Serum UCH-L1 ve TDP-43 Düzeyleri Otizmde Bozulmuş Ubikuinasyon Sürecini Yansıtabilir mi?. Nöropsikiyatri Arşivi, Cilt: 54 - Sayı: 3, 267–271. https://ajindex.com/articles/292845

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