Journals / Nöropsikiyatri Arşivi / 2017 / Cilt: 54 - Sayı: 1

Retinal Nerve Fiber Layer Thickness Measurement by Spectral-Domain Optical Coherence Tomography in Patients with Major Depressive Disorder

Major Depresif Bozukluk Hastalarında Optik Koherens Tomografi ile Retinal Sinir Lifi Tabakası Kalınlığı Ölçümü

Pages
62–66
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Using optical coherence tomography (OCT), the peripapillary RNFL thickness in major depressive disorder patients and control subjects was measured and compared at each location ts: Patients with major depressive disorder did not show a statistically significant reduction in overall peripapillary RNFL thickness.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: In recent years, an increasing number of studies have researched retinal nerve fiber layer (RNFL) changes in neurodegenerative disorders.
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Key Findings & Data:In this study, our aim was to determine structural RNFL changes in patients with major depressive disorder.Methods: A total of 30 patients with major depressive disorder and 30 age- and sex-matched controls were recruited.
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Conclusion & Impact:Using optical coherence tomography (OCT), the peripapillary RNFL thickness in major depressive disorder patients and control subjects was measured and compared at each location ts: Patients with major depressive disorder did not show a statistically significant reduction in overall peripapillary RNFL thickness.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: In recent years, an increasing number of studies have researched retinal nerve fiber layer (RNFL) changes in neurodegenerative disorders. In this study, our aim was to determine structural RNFL changes in patients with major depressive disorder.Methods: A total of 30 patients with major depressive disorder and 30 age- and sex-matched controls were recruited. Using optical coherence tomography (OCT), the peripapillary RNFL thickness in major depressive disorder patients and control subjects was measured and compared at each location ts: Patients with major depressive disorder did not show a statistically significant reduction in overall peripapillary RNFL thickness. Conclusion: Our study showed that RNFL thickness is not reduced in major depressive disorder patients and that OCT is not a useful tool for diagnosing and monitoring the progression of major depressive disorder. This study suggests that the pathophysiology of unipolar depression is different than in neurodegenerative disorders, pervasive developmental disorders, schizophrenia, and bipolar disorder.

Özet

Amaç: Son yıllarda, nörodejeneratif hastalıklarda retinal sinir lifi tabakasındaki (RSLT) değişiklikleri araştıran çalışmalar artmaktadır. Bu çalışmada, bizim amacımız majör depresif bozukluğu olan hastalarda retinal sinir lifi tabakasındaki yapısal değişiklikleri saptamaktır Yöntem: Structured Clinical Interview for DSM (SCID) görüşmesi sonucunda majör depresif bozukluk tanısı konan 30 hasta ve yaş, cinsiyet açısından hastalarla eşleştirilen 30 sağlıklı birey kontrol grubu olarak çalışmaya dahil edilmiştir. Optik Koherens Tomografi (OKT) kullanılarak, majör depresif bozukluk hastalarında ve kontrol grubunda, retinal sinir lif tabakası (RSLT) kalınlığı her lokasyonda ölçülüp karşılaştırılmıştır. Bulgular: Majör depresif bozukluk tanılı hastaların RSLT kalınlığında, istatiksel olarak anlamlı bir azalma görülmemiştir. Sonuç: Çalışmamız, majör depresif bozukluk hastalarında RSLT kalınlığının azalmadığını ve majör depresif bozukluk tanısında ve hastalığın gidişini izlemede OKT kullanımının uygun araç olmadığını göstermiştir. Bu çalışma unipolar depresyon patofizyolojisinin, nörodejeneratif hastalıklar, yaygın gelişimsel bozukluklar, şizofreni ve bipolar bozukluktan farklı olabileceğini göstermektedir.

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Cite This Article

SÖNMEZ, İ., KÖŞGER, F., AYKAN, Ü. (2017). Retinal Nerve Fiber Layer Thickness Measurement by Spectral-Domain Optical Coherence Tomography in Patients with Major Depressive Disorder. Nöropsikiyatri Arşivi, Cilt: 54 - Sayı: 1, 62–66. https://ajindex.com/articles/292277

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