Journals / Nöropsikiyatri Arşivi / 2019 / Cilt: 56 - Sayı: 4

Effect of Exercise on Major Depressive Disorder and Schizophrenia: A BDNF Focused Approach

Egzersizin Depresyon ve Şizofreni Üzerine Etkisi: BDNF Odaklı Bir Bakış

Pages
302–310
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results showed that aerobic exercise caused different responses on BDNF levels, and some of the studies were accompanied by the improvement in cognitive functions in BDNF changes.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Psychiatric disorders are remarkable health problems that cause a massive social and economic burden, and the issue of their long-term and effective treatment is subjected to discussion.
📊
Key Findings & Data:The effect of physical activity and exercise is under investigation in the treatment of the major depressive disorder (MDD) and schizophrenia which are accompanied by cognitive dysfunctions.
💡
Conclusion & Impact:The results showed that aerobic exercise caused different responses on BDNF levels, and some of the studies were accompanied by the improvement in cognitive functions in BDNF changes.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Psychiatric disorders are remarkable health problems that cause a massive social and economic burden, and the issue of their long-term and effective treatment is subjected to discussion. The effect of physical activity and exercise is under investigation in the treatment of the major depressive disorder (MDD) and schizophrenia which are accompanied by cognitive dysfunctions. Scientists focus on the positive effects of exercise on learning, memory and attention parameters while investigating the regulatory role of brain-derived neurotrophic factor (BDNF). In this review, the effect of aerobic exercise on peripheral BDNF levels in MDD and schizophrenia is examined by including human studies in which acute and chronic aerobic exercise are applied. The results showed that aerobic exercise caused different responses on BDNF levels, and some of the studies were accompanied by the improvement in cognitive functions in BDNF changes. In order to comprehend the effect of aerobic exercise in MDD and schizophrenia, it is understood that applying studies on larger and paired participant groups with different exercise frequencies and tensions in necessary.

Özet

Psikiyatrik bozukluklar, uzun süreli ve etkili tedavi sorununun tartışıldığı, büyük sosyal ve ekonomik yüke neden olan sağlık sorunları kapsamında dikkat çekmektedir. Bilişsel işlev bozukluklarının eşlik ettiği major depresif bozukluk (MDB) ve şizofreninin tedavisinde, fiziksel aktivite ile egzersizin etkisine işaret edilmektedir. Bilim insanları, egzersizin öğrenme, bellek ve dikkat parametreleri üzerindeki olumlu etkilerine odaklanmakta, burada beyin kökenli nörotrofik faktörün (BDNF) düzenleyici rolünü araştırmaktadır. Bu gözden geçirmede, akut ve kronik aerobik egzersizin uygulandığı insan çalışmaları ele alınarak aerobik egzersizin MDB ve şizofreni tablosunda periferik BDNF düzeylerine olan etkisi incelenmiştir. Sonuçlar, aerobik egzersizin BDNF düzeyleri üzerinde farklı yanıtlara neden olduğunu göstermiş, çalışmaların bir bölümünde BDNF değişikliklerine bilişsel işlevlerdeki iyileşme eşlik etmiştir. MDB ve şizofrenide aerobik egzersizin etkisini kavramak için, egzersiz sıklığı ve şiddeti bakımından farklı, daha geniş ve eşleştirilmiş katılımcı gruplarında çalışmalara gereksinim olduğu görülmüştür.

🔖

Cite This Article

GÖKÇE, E., GÜNEŞ, E., NALÇACI, E. (2019). Effect of Exercise on Major Depressive Disorder and Schizophrenia: A BDNF Focused Approach. Nöropsikiyatri Arşivi, Cilt: 56 - Sayı: 4, 302–310. https://ajindex.com/articles/292223

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (2)

  1. Zoladz JA, Pilc A. The effect of physical activity on the brain derived neurotrophic factor: from animal to human studies. J Physiol Pharmacol 2010;61:533–41
  2. Firth J, Stubbs B, Rosenbaum S, Vancampfort D, Malchow B, Schuch F, Elliott R, Nuechterlein KH, Yung AR. Aerobic Exercise Improves Cognitive Functioning in People With Schizophrenia: A Systematic Review and MetaAnalysis. Schizophr Bull 2017;43:546–556. [CrossRef] 3. Erickson K, Voss M, Prakash R, Basak C, Szabo A, Chaddock L, Kim J, Heo S, Alves H, White S, Wojcicki T, Mailey E, Vieira V, Martin S, Pence B, Woods J, McAuley E, Kramer A. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci U S A 2011;108;3017–3022. [CrossRef] 4. Pliego-Rivero FB, Byatti N, Giannakoulopoulos X, Glover V, Bradford HF, Stern G, Sandier M. Brain-derived neurotrophic factor in human platelets. Biochem Pharmacol 1997;54:207–209. [CrossRef] 5. Poduslo JF, Curran GL. Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF. Brain Res Mol Brain Res 1996;36:280–286. [CrossRef] 6. Halbach O, Halbach V. BDNF effects on dendritic spine morphology and hippocampal function. Cell Tissue Res 2018;373:729–741. [CrossRef] 7. Panja D, Bramham CR. BDNF mechanisms in late LTP formation: A synthesis and breakdown. Neuropharmacology 2014;76:664–676. [CrossRef] 8. Dougherty KD, Dreyfus CF, Black IB. Brain-derived neurotrophic factor in astrocytes, oligodendrocytes, and microglia/macrophages after spinal cord injury. Neurobiol Dis 2000;7:574–85. [CrossRef] 9. Numakawa T, Suzuki S, Kumamaru E, Adachi N, Richards M, Kunugi H. BDNF function and intracellular signaling in neurons. Histol Histopathol 2010;25:237–258. [CrossRef] 10. Hwang J, Brothers RM, Castelli DM, Glowacki EM, Chen YT, Salinas MM, Kim J, Yung Y, Calvert HG. Acute high-intensity exercise-induced cognitive enhancement and brain- derived neurotrophic factor in young, healthy adults. Neurosci Lett 2016;630:247–253. [CrossRef] 11. Hung CL, Tseng JW, Chao HH, Hung TM, Wang HS. Effect of Acute Exercise Mode on Serum Brain-Derived Neurotrophic Factor (BDNF) and Task Switching Performance. J Clin Med 2018;24;7:301. [CrossRef] 12. Sartorius A, Hellweg R, Litzke J, Vogt M, Dormann C, Vollmayr B, DankerHopfe H, Gass P. Correlations and discrepancies between serum and brain tissue levels of neurotrophins after electroconvulsive treatment in rats. Pharmacopsychiatry 2009;42:270–276. [CrossRef] 13. Yong