Journals / Namık Kemal Tıp Dergisi / 2019 / Cilt: 7 - Sayı: 3

The Relation Between Dipper, Non-dipper Hypertension and Uric Acid Level and Clearance in Newly Diagnosed Hypertensive Patients

YENİ TANI HİPERTANSİF HASTALARDA DİPPER, NON-DİPPER HİPERTANSİYONUN ÜRİK ASİT DÜZEYİ VE KLİRENSİ İLE İLİŞKİSİ

Pages
265–270
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion:In this study where UA level and clearance in dipper, non-dipper hypertensive cases of newly diagnosed hypertension are evaluated; UA clearance was found to be positively correlated with higher BP where as the level of UA was not significantly elevated in hypertension cases and non-dipper hypertension patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim:While there are some studies reporting that higher levels of uric acid (UA) has an effect on the development of hypertension (HT), the relation between dipper, non-dipper HT and hyperuricemia and UA clearance is not clear.
📊
Key Findings & Data:Materials and Methods:59 patients with diagnosed HT and 24 healthy individuals who were followed-up in departments of Internal Medicine and Nephrology, were included into the study.
💡
Conclusion & Impact:Conclusion:In this study where UA level and clearance in dipper, non-dipper hypertensive cases of newly diagnosed hypertension are evaluated; UA clearance was found to be positively correlated with higher BP where as the level of UA was not significantly elevated in hypertension cases and non-dipper hypertension patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim:While there are some studies reporting that higher levels of uric acid (UA) has an effect on the development of hypertension (HT), the relation between dipper, non-dipper HT and hyperuricemia and UA clearance is not clear. In our study;Weaimed to evaluate the relationship between dipper, non-dipper HT and UA level and clearance in newly diagnosed HTpatients. Materials and Methods:59 patients with diagnosed HT and 24 healthy individuals who were followed-up in departments of Internal Medicine and Nephrology, were included into the study. UA clearance and sodium in 24 hour urine were analyzed. Office blood pressure (BP) and 24-hour ambulatory blood pressure (24-h ABPM) were measured. Blood sample was obtained for biochemical analysis. Results:59 newly diagnosed HT patients and 24 healthy individuals were included into the study. The correlation analysis of the hypertensive patient group revealed a positive correlation between the UA and creatinine levels (r = 0.509) (p <0.01) and a negative correlation between UA level and UA clearance (r = - 0.494) (p <0.01). Non-dipper cases consisted of 44.1% of the HT patients. There was no statistically significant difference among the demographic and laboratory parameters between dipper and non- dipper patients. Conclusion:In this study where UA level and clearance in dipper, non-dipper hypertensive cases of newly diagnosed hypertension are evaluated; UA clearance was found to be positively correlated with higher BP where as the level of UA was not significantly elevated in hypertension cases and non-dipper hypertension patients.

Özet

Amaç:Günümüzde hipertansiyon (HT) gelişiminde ürik asit (ÜA) yüksekliğinin etkisi olduğunu bildirir çalışmalar mevcut iken dipper, non-dipper HT ile hiperürisemi ve ÜA klirensi arasındaki ilişki net değildir. Biz çalışmamızda; yeni tanı hipertansif hastalarda dipper, non-dipper HT’un, ÜA düzeyi ve klirensi ile ilişkisini değerlendirmeyi amaçladık. Materyal ve Metot:Çalışmamıza hastanemiz İç Hastalıkları ve Nefroloji kliniğinde takipli 59 yeni tanı primer HT hastası ve 24 sağlıklı birey dahil edildi. ÜA klirensi, 24-s idrarda sodyum, 24 saatlik ambulatuar KB ölçümü (24-s AKBM) ve ofis kan basıncı (KB) ölçümü yapıldı. Biyokimyasal parametreler için kan örneği alındı. Bulgular:Çalışmaya 59 HT hastası ile, 24 sağlıklı birey alındı. HT hasta grubunun korelasyon analizinde ÜA düzeyi ile kreatinin düzeyi arasında pozitif korelasyon(r=0.509) (p<0.01), ÜA klirensi ile ise negatif korelasyon(r=-0.494) (p<0.01) saptanmıştır. HT hastaların % 44.1’i non-dipper idi. Dipper ve non dipper hastaların demografik ve laboratuvar parametrelerinin karşılaştırılmasında anlamlı fark saptanmadı. Sonuç:Sonuç olarak yeni tanı HT hastalarında dipper, non-dipper hipertansiflerde ÜA düzeyi ve ÜA klirensini değerlendirdiğimiz çalışmamızda, HT hastalarında ve non-dipper HT hastalarında ÜA düzeyinde anlamlı yükseklik saptamaz iken ÜA klerensinin KB yüksekliği ile pozitif ilişkili olduğunuz saptadık.

🔖

Cite This Article

KARA, S. P. (2019). The Relation Between Dipper, Non-dipper Hypertension and Uric Acid Level and Clearance in Newly Diagnosed Hypertensive Patients. Namık Kemal Tıp Dergisi, Cilt: 7 - Sayı: 3, 265–270. https://ajindex.com/articles/289030

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. K. Chaudhary, K. Malhotra, J. Sowers, A. AroorUric acid — key ingredient in the recipe for cardiorenal metabolic syndrome.Cardiorenal Medicine.2013
  2. 3(3):208-220 2. Maiuolo J, Oppedisano F, Gratteri S, Muscoli C, Mollace V. Regulation of uric asid metabolism and excreation. International Journal of Cardiology. 2016
  3. 14 3. Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S,et al. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?Hypertension.2003
  4. 41(6):1183-90. 4. Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovascular risk. New England Journal of Medicine 2008
  5. 359(17):1811-21. 5. Nakagawa T, Kang DH, Feig D, Sanchez-Lozada LG, Srinivas TR, Sautin Y, et al. Unearthing uric acid: an ancient factor with recently found significance in renal and cardiovascular disease. KidneyInternational.2006
  6. 69(10):1722-5. 6. Corry DB, Eslami P, Yamamoto K, Nyby MD, Makino H, Tuck ML. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system. Journal of Hypertension. 2008
  7. 26(2):269–275. 7. Sanchez-Lozada LG, Tapia E, Soto V, Avila-Casado C, Franco M, Wessale JL, et al. Effect of febuxostat on the progression of renal disease in 5/6 nephrectomy rats with and without hyperuricemia. Nephron Physiology. 2008
  8. 108(4):69–78. 8. Johnson RJ, Feig DI, Herrera-Acosta J, Kang DH. Resurrection of uric acid as a causal risk factor in essential hypertension. Hypertension. 2005
  9. 45(1):18– 20. 9. Sundstro¨m J, Sullivan L, D’Agostino RB, Levy D, Kannel WB, Vasan RS. Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence in the Framingham Heart Study. Hypertension. 2005
  10. 45(1):28-33. 10. Kalyon S, Uzun H, Helvacı A, Yenice N. Hipertansiyonun hiperürisemi ile ilişkisi. Okmeydanı Tıp Dergisi. 2011
  11. 27(3):138-43. 11. Messerli FH, Frohlich ED, Drenslinski GR, Suarez DH, Aristimuno GG. Serum uric acid in essential hypertension: An indicator of renal vascular involvement. Annals of Internal Medicine. 1980
  12. 93(6):817-21. 12. Sanchez-Lozada LG, Tapia E, Avila-Casado C, Soto V, Franco M, Santamaria J, Nakagawa T, Rodríguez- Iturbe B, Johnson RJ, Herrera-Acosta J. Mild hyperuricemia induces glomerular hypertension in normal rats. American Journal of Physiology. 2002
  13. 283(5):F1105-10. 13. Sanchez-Lozada LG, Soto V, Tapia E, Avila-Casado C, Sautin YY, Nakagawa T, Franco M, Rodríguez-Iturbe B, Johnson RJ. Role of oxidative stress in the