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Journals / Genel Tıp Dergisi / 2016 / Cilt: 26 - Sayı: 2

Alopesi areata hastalarında nötrofil/lenfosit oranının ve diğer inflamatuar parametrelerin normal popülasyon ile karşılaştırılması

Mehmet Emin YANIK
Gamze ERFAN
HÜLYA ALBAYRAK
SONAT PINAR KARA
Dilek SOLMAZ
Mustafa KULAÇ
Pages
46–49
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

And, as for CRP, larger-scale studies need to be done in order to demonstrate if it can serve as a marker or not.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The objective of this study is to calculate the neutrophil-lymphocyte ratio (NLR) and other inflamatory paramaters like erythrocyte sedimentation rate (ECR) and C-reactive protein results (CRP) in Alopecia areata(AA) patients and determine the association between thoose laboratory values and AA.Method: 234 patients with AA and 37 healthy subjects were enrolled in the study.
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Key Findings & Data:NLR was calculated and recorded.Results: While the difference between patient and control groups in terms of value of Neutrophils, Leukocytes, Hb and Esr were found to be insignificant (p>0.05), numbers of Lymphocyte (p=0,02) and value of Crp ( P <0.001) in patients were found to be higher than those of healthy controls.Conclusion: This study demonstrates that NLR can not serve as a usuful marker for AA.
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Conclusion & Impact:And, as for CRP, larger-scale studies need to be done in order to demonstrate if it can serve as a marker or not.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The objective of this study is to calculate the neutrophil-lymphocyte ratio (NLR) and other inflamatory paramaters like erythrocyte sedimentation rate (ECR) and C-reactive protein results (CRP) in Alopecia areata(AA) patients and determine the association between thoose laboratory values and AA.Method: 234 patients with AA and 37 healthy subjects were enrolled in the study. Number of neutrophil, lymphocyte, leucocyte, ESR and CRP were ascertained from patient's medical records. NLR was calculated and recorded.Results: While the difference between patient and control groups in terms of value of Neutrophils, Leukocytes, Hb and Esr were found to be insignificant (p>0.05), numbers of Lymphocyte (p=0,02) and value of Crp ( P <0.001) in patients were found to be higher than those of healthy controls.Conclusion: This study demonstrates that NLR can not serve as a usuful marker for AA. And, as for CRP, larger-scale studies need to be done in order to demonstrate if it can serve as a marker or not.

Özet

Amaç: Bu çalışmanın amacı; alopesi areata(AA) hastalarında nötrofil/lenfosit oranını (NLR), Eritrosit sedimentasyon hızı(ESR), C reaktif protein(CRP) gibi inflamatuar parametreleri normal populasyon ile kıyaslayarak bu parametrelerin AA hastalarında inflamasyonun şiddetini ölçebilecek bir marker olarak kullanılabilirliğini değerlendirmektir.Yöntem: Çalışmaya klinik olarak AA tanısı konmuş 234 hasta dahil edildi. 37 sağlıklı kişi alındı. Hasta dosyalarından lökosit, nötrofil ve lenfosit sayıları ile ESR ve CRP sonuçları kaydedildi. NLR ise hesaplanarak bulunup kaydedilmiştir. Bulgular: Hasta ve kontrol grubu arasında Lökosit, Nötrofil, ,Hb ve Esr değerleri ile NLR açısından anlamlı fark saptanmazken(p>0.05) Lenfosit sayıları(p=0,02) ve Crp( P <0.001) değeri AA hastalarında yüksek olduğu tesbit edilmiştir. Sonuç: Sonuç olarak AA hastalığında NLR değerinin kullanılabilecek bir belirteç olmadığı kanaatine varılmıştır. CRP'nin AA için kullanılabilir bir marker olduğunu gösterebilmek için daha geniş ölçekli çalışmalar yapmak gereklidir.

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Cite This Article

YANIK, M. E., ERFAN, G., ALBAYRAK, H., KARA, S. P., SOLMAZ, D., KULAÇ, M. (2016). Alopesi areata hastalarında nötrofil/lenfosit oranının ve diğer inflamatuar parametrelerin normal popülasyon ile karşılaştırılması. Genel Tıp Dergisi, Cilt: 26 - Sayı: 2, 46–49. https://ajindex.com/articles/177159

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References (15)

  1. Sperling L. Alopecias. In: Bolognia J, Jorizzo J, Rapini R, eds. Dermatology. New York: Mosby Elsevier; 2008: 992-5
  2. Madani S, Shapiro J. Alopecia areata update. J Am Acad Dermatol 2000; 42: 549-566; quiz 567-70
  3. Van der Steen P, Traupe H, Happle R, Boezeman J, Sträter R, Hamm H. The genetic risk for alopecia areata in first degree relatives of severely affected patients. An estimate. Acta Derm Venereol 1992; 72(5):373-5
  4. Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med 2012 26;5(1):2
  5. Bhat T, Teli S, Rijal J, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther 2013;11:55-9
  6. Ozturk ZA, Kuyumcu ME, Yesil Y, et al. Is there a link between neutrophil-lymphocyte ratio and microvascular complications in geriatric diabetic patients? J Endocrinol Invest 2013;36:593-9
  7. Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, McMillan DC, Clarke SJ. The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol 2013;88:218-30
  8. Ahsen A, Ulu MS, Yuksel S, et al. As a new inflammatory marker for familial Mediterranean fever: neutrophil-to-lymphocyte ratio. Inflammation 2013;36:1357-62
  9. Celikbilek M, Dogan S, Ozbakır O, et al. Neutrophil- lymphocyte ratio as a predictor of disease severity in ulcerative colitis. J Clin Lab Anal 2013;27:72-6
  10. Ataseven A, Bilgin AU, Kurtipek GS. The importance of neutrophil lymphocyte ratio in patients with psoriasis. Mater Sociomed 2014;26:231-3
  11. Sen BB, Rifaioglu EN, Ekiz O, Inan MU, Sen T, Sen N. Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis. Cutan Ocul Toxicol 2014;33:223
  12. Alkhalifah A, Alsantali A, Wang E, McElwee KJ, Shapiro J. Alopecia areata update: Part I. Clinical picture, histopathology, and pathogenesis. J Am Acad Dermatol 2010;62:177- 88
  13. Matzer F, Egger JW, Kopera D. Psychosocial stress and coping in alopecia areata: a questionnaire survey and qualitative study among 45 patients. Acta Derm Venereol 2011;91:318-27
  14. Ozlu E, Karadag AS, Akdeniz N, Uzuncakmak TK. Acitretin-induced alopecia areata: a case report. Cutan Ocul Toxicol 2015;34:248-50. 15. ong J, Lim SW. Alopecia areata as a paraneoplastic syndrome of Hodgkin's lymphoma: A case report. Mol Clin Oncol 2014;2:596-8
  15. Qiao J, Zhou G, Ding Y, Zhu D, Fang