AI Summary & Key Takeaways
AI InsightRenal tissue damage was significiantly less in carnitine used rats as a result of this study.
📌 3 Key Takeaways
Abstract
The renal damage due to the renal ischemia and reperfusion outcomes in recent years releated to the increasing surgical procedures such as nephron sparing surgery, partial nephrectomy, renal transplantation and trauma. The effect of carnitine for decreasing tissue damage was investigated in this study. Renal tissue damage was created in Wistar type rats by ischemia and reperfusion. An anti-ischemic agent L-Carnitine was applied to the rats for reduced tissue damage in kidney. Malonildialdeheit (MDA) level in renal tissue and histopathologic examination were made in order to determine the renal tissue damage. Renal tissue damage was significiantly less in carnitine used rats as a result of this study.
Özet
Son yıllarda artan nefron koruyucu cerrahi,parsiyel nefrektomi,renal transplantasyon,şok ve travma gibi olaylar böbrek iskemisi ve reperfüzyonunda oluşan doku hasarını gündeme getirmiştir.Bu çalışma doku hasarını azaltmada kamilinin etkisi gözlemek amacıyla yapıldı. Wistar tipi raflarda iskemi-reperfüzyon oluşturularak doku hasan oluşturuldu.Serbest radikal giderici ve anti-iskemik etkiye sahip L-Karnitin sistemik olarak rotlara uygulandı. Renal hasan tespit etmek için renal dokuda malonildialdehit (MDA) tayini ve histopatolojik inceleme yapıldı. Araştırına sonucunda kamilin verilen radarda doku hasarının anlamlı derecede azaldığı tespit edildi. (p<0.05)