AI Summary & Key Takeaways
AI InsightAs a result, urine CTX levels measured at the end of the first month of the treatment can help estimate the femur BMD increase in the following years of long term risedronate treatment.
📌 3 Key Takeaways
Abstract
In this study we aimed to evaluate and compare the effects of risedronate on bone mineral density (BMD) and biochemical markers in postmenopausal osteoporosis. One hundred three patients with postmenopausal osteoporosis were included in the study. The patients were divided into two groups as group 1 and group 2. The patients in group I were treated with 5 mg risedronate and 500 mg calcium daily, while group 2 were treated only with 500 mg of calcium. Densitometric measurements of lumbar spine and femur were performed before treatment and at the end of 12 months after treatment. Additionally, BMD measurements of 33 patients in group 1 were repeated at the end of 2nd year. Serum levels of osteocalcin and urine C telopeptyde (CTX) levels were measured before therapy and at the 1st and 3rd months of the therapy period. Significant decreases were observed in urine CTX and serum osteocalcin levels beginning from the 1st month in group 1 (p<0.05). In group 1, BMD of femur neck and lumbar spine regions increased significantly at the 12th month of the study. Femur trochanter BMD was also found to increase when compared with pretreatment values at the end of the second year evaluation (p<0.05). No significant correlation of urine CTX and serum osteocalcin levels which were measured at the 1st and 3rd months of the therapy was found with the densitometric changes at the end of one year in group I (p>0.05). However increase of mean BMD values of femur trochanter at second year according to pre-treatment values correlated with decrease of urine CTX values at the first month (p<0.05). As a result, urine CTX levels measured at the end of the first month of the treatment can help estimate the femur BMD increase in the following years of long term risedronate treatment.
Özet
Bu çalışmada risedronatın postmenopozal osteoporozda kemik mineral yoğunluğu (KMY) ve biyokimyasal belirteçler üzerine olan etkilerinin birbiriyle ilişkisini değerlendirmek amaçlandı. Çalışmaya 103 postmenopozal osteoporozlu kadın olgu alındı. Bu olguların 58'i grup 1, 45'i grup 2 olmak üzere ikiye ayrıldı. Grup 1'e günlük 5 mg risedronat ve 500 mg kalsiyum, grup 2'ye ise sadece günlük 500 mg kalsiyum verildi. Lomber vertebra ve femurun dansitometrik ölçümleri tedavi öncesi ve 12. ay sonunda yapıldı. Ayrıca grup 1'deki 33 hastanın 2. yılda KMY ölçümleri tekrarlandı. Tedavi öncesi, tedavi sonrası 1. ve 3. aylarda serum osteokalsin ve idrar C telopeptit (CTX) düzeyleri değerlendirildi. Grup 1'de çalışmanın 1. ayından itibaren idrar CTX ve osteokalsin düzeylerinde anlamlı bir düşüş saptandı (p 0.05). Fakat tedavi öncesine göre 2. yıldaki ortalama femur trokanter bölgesindeki KMY artışı, 1. ayda ortaya çıkan CTX düşüşü ile korale bulundu (p<0.05). Sonuç olarak, uzun süreli risedronat kullanılacak hastalarda, tedavinin daha 1. ayında idrar CTX düzeyine bakılarak, ilerleyen yıllardaki femur KMY artışı tahmin edilebilir.