Journals / Nöropsikiyatri Arşivi / 2014 / Cilt: 51 - Sayı: 3

Primer ekstranodal intestinal lenfomalı bir hastada gözlenen guillain barré sendromu: paraneoplastik kökenli mi, ilaç yan etkisi mi, rastlantısal mı?

Guillain-barre syndrome in a patient with primary extranodal ıntestinal non-hodgkin's lymphoma: paraneoplastic, drug induced or coincidental?

Pages
288–292
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Guillain-Barré syndrome can potentially be fatal and mimic chemotherapy- induced neurotoxicity, especially in patients with lymphoma, and therefore, must be considered in the differential diagnosis.

📌 3 Key Takeaways

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Objective & Hypothesis:Neurological involvement is observed in 5%-25% of patients with lymphoma being either the first presentation of the disease or emerging during its course.
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Key Findings & Data:A 66-year-old male patient with primary extranodal intestinal lymphoma developed quadriparesis, sensory deficits and autonomic dysfunction while receiving chemotherapy.
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Conclusion & Impact:Guillain-Barré syndrome can potentially be fatal and mimic chemotherapy- induced neurotoxicity, especially in patients with lymphoma, and therefore, must be considered in the differential diagnosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Neurological involvement is observed in 5%-25% of patients with lymphoma being either the first presentation of the disease or emerging during its course. However, Guillain-Barré syndrome is rarely reported. In this article, we present a case with intestinal lymphoma developing Guillain-Barré syndrome during the course of the disease. A 66-year-old male patient with primary extranodal intestinal lymphoma developed quadriparesis, sensory deficits and autonomic dysfunction while receiving chemotherapy. The findings of clinical, electrophysiological and laboratory examinations were consistent with Guillain-Barré syndrome. Guillain-Barré syndrome can potentially be fatal and mimic chemotherapy- induced neurotoxicity, especially in patients with lymphoma, and therefore, must be considered in the differential diagnosis.

Özet

Lenfomalı hastaların %5-%25’inde nörolojik tutulum gerek ilk klinik prezentasyon olarak, gerekse hastalık seyri sırasında gözlenebilir. Ancak Guillain Barré sendromu nadiren bidirilmiştir. Bu yazıda intestinal lenfoma seyrinde gelişen bir Guillain Barré sendromu olgusu sunulmuştur. Bilinen primer ekstranodal intestinal lenfoması olan ve kemoterapi alan 66 yaşında bir erkek hastada subakut kuadriparezi, duyu bozukluğu ve otonomik disfonksiyon gelişmiştir. Klinik muayene, elektrofizyolojik incelemeler ve laboratuar bulgularının Guillain-Barré sendromu ile uyumlu olduğu saptanmıştır. Guillain-Barré sendromu ölümcül bir hastalık olma potansiyeline sahiptir ve özellikle lenfoma hastalarında kullanılan kemoterapötik ajanların nörotoksik yan etkilerini taklit edebilir, bu nedenle ayırıcı tanıda gözetilmesi ve tedavisinin hızla başlatılması önemlidir.

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Cite This Article

KIYAT, A. A., OKUTUR, K., TÜZÜN, E., HASBAL, B., BOYACIYAN, A., KRESPİ, Y., DEMİR, G. (2014). Primer ekstranodal intestinal lenfomalı bir hastada gözlenen guillain barré sendromu: paraneoplastik kökenli mi, ilaç yan etkisi mi, rastlantısal mı?. Nöropsikiyatri Arşivi, Cilt: 51 - Sayı: 3, 288–292. https://ajindex.com/articles/286444

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